348
N. K. KARAMANOS
I H.patin -/ HS-Iy ....
~
CCXT
0
lfO~H.OH
O~O'
HO
Oft'
CH,oA"
Suggested
No
Formulas
terminology
R2
R6
Y
1
~UA-[1~4]-GlcN
~di-nonS
H
H
H
2
~UA-[1 ~4]-GlcNAc
aLldi-nonS
H
H
Ac
3
~UA-2S-[1 ~4]-GlcN
~di-mon02S
S03'
H
H
4
~UA-2S-[ 1 ~4]-GlcNAc
a~di-mono2S
S03'
H
Ac
5
~UA-[ 1 ~4]-GlcN-6S
~di-mon06S
H
S03'
H
6
~UA-[ 1 ~4]-GlcNAc-6S
aLldi-mon06S
H
S03'
Ac
7
~UA-[1 ~4]-GlcNS
~di-monoNS
H
H
S03'
8
~UA-2S-[ 1 ~4]-GlcN-6S
~di-di(2,6)S
S03'
S03'
H
9
~U A-2S-[ 1 ~4]-GlcNAc-6S aLldi-di(2,6)S
S03'
S03'
Ac
10
~UA-2S-[ 1 ~4]-GlcNS
~di-di(2,N)S
S03'
H
S03'
11
~UA-[1~4]-GlcNS-6S
~di-di(6,N)S
H
S03'
S03'
12
~UA-2S-[1~4]-GlcNS-6S
~di-tri(2,6,N)S
S03'
S03'
S03'
a = acetylated
Fig. 24.5. Primary structure of heparan sulfate and heparin and of all known ~·disaccharides
obtainable by digestion with heparin lyases I, II and III. Arrows indicate the sites degraded by hepa·
rin lyases. Reprinted from Karamanos et aI. 1997
3.2
Protein (ore of Proteoglycans
Distinct and non-genetically related proteins serve as protein cores of the various
PGs. Their combination with certain GAG chains gives to each PG unique structural entity and biological functions. Some protein cores may contain one or