Exploring Functions for Glycosylation in Host Defence
335
Fig. 23.10. Glycan processing is influenced by the 30
structure of the protein:
HPLC profiles of the glycan
pools released from a range
of leucocyte antigens
expressed in CHO cells. C02
contains an oligomannose
series (ManS-ManS) not
found in C04S. In C02, Asn
65 has been shown to contain only oligomannose sugars (Recny et a!., 1992)
Q)
l)
C
Q)
l)
(/J
~
o
::::l
LL
sCD 59
(Hu)
sCD5d 1
(H u)
sCD4
(Rat)
sCD48
M5
A2Gl
A2G2F
A2G2L1F
A2G2L2F
I
A2G2F
A2GOF
A2G2/ M6
G2F
A2G 2F
(Rat) M3(GN)F
A2G1F
A2+GO
A3GOF/
A3G3F
sCD2
(Hu)
60
A2GOF
M3 0 " l M5 I
... ..t
M5
I
A4G4F
A4G4L1F
I I A4G4L2F
...... I
M6 M7 A3G3F
Minutes