Structure, Dynamics and Function of the Proton Pump Bacteriorhodopsin
239
Engelman D M, Zaccai G (1980) Bacteriorhodopsin is an inside-out protein. Proc. Natl. Acad. Sci. USA
77, 5894-5898
Essen L, Siegert R, Lehmann W D, Oesterhelt D (1998) Lipid patches in membrane protein oligomers:
crystal structure of the bacteriorhodopsin-lipid complex. Proc. Nat!. Acac. Sci. USA 95,
11673-11678
Fahmy K, Weidlich 0, Engelhard M, Tittor J, Oesterhelt D, Siebert F (1992) Identification of the Proton
Acceptor of Schiff Base Deprotonation in Bacteriorhodopsin: A Fourier-Transform-Infrared Study
of the Mutant Asp85Glu in its Natural Lipid Environment. Photochem.Photobiol. 56:1073-1083.
Glaeser R M, Baldwin J, Ceska T A, Henderson R (1986) Electron Diffraction Analysis of the M412
Intermediate of Bacteriorhodopsin. Biophys. J. 50, 913-920
Grigorieff N, Ceska T A, Downing K H, Baldwin J M, Henderson R. (1996) Electron-crystallographic
refinement of the structure of bacteriorhodopsin. J. Mol. BioI. 259, 393 -421
Heberle, J. and C. Zscherp. 1996. ATR/FT-IR difference spectroscopy of biological matter with microsecond time resolution. Appl.Spectrosc. 50:588-596.
Heberle J, Biildt G, Koglin E, Rosenbusch J P, Landau E M (l998) Assessing the functionality of a
membrane protein in a three-dimensional crystal. J Mol Bioi 281 :587 - 592.
Henderson R (1975) The Structure of the Purple Membran from Halobacterium halobium: Analysis of
the X-ray Diffraction Pattern. J. Mol. BioI. 93, 123-138
Henderson R, Baldwin J M , Ceska T A, Zemlin F, Beckmann E, Downing K H (1990) Model for the
structure of bacteriorhodopsin based on high-resolution electron cryo-microscopy. J. Mol. BioI.
213, 899-929
Henderson R, Unwin P N T (1975) Three-dimensional model of purple membrane obtained byelectron microscopy. Nature 257, 28-32
Heyn M P, Westerhausen, J, Wallat I and Seiff F (1988) High-sensitivity neutron diffraction of membranes: Location of the Schiff base end of the chromophore of bacteriorhodopsin. Proc. Nat!. Acad.
Sci. USA 85, 2146-2150
Jubb J S, Worcester D L, Crespi H L, Zaccai G (1984) Retinal location in purple membrane of Halobacterium halobium: a neutron diffraction study of membranes labelled in vivo with deuterated retinal. EMBO J. 3, 1455-1461
.
Koch M H J , Dencher N A , Osterhelt D, Pl6hn H J, Rapp G, Biildt G. (l99I) Time-resolved X-ray diffraction study of structural changes associated with the photo cycle of bacteriorhodopsin. EMBO
J.,IO,521-526
Kimura Y, Vassylyev D G , Miyazawa, A, Kidera A, Matsushima M, Mitsuoka K, Murata K, Hirai T,
Fujiyoshi, Y. (1997) Surface ofbacteriorhodopsin revealed by high-resolution electron crystallography. Nature 389, 206-211
Landau E M, Rosenbusch J P (1996) Lipidic cubic phases: A novel concept for the crystallization of
membrane proteins. Proc. Natl. Acad Sci. USA 93,14532-14535
Lanyi J K (1997) Mechanism of ion transport across membranes. Bacteriorhodopsin as a prototype
for proton pumps. J Bioi Chem 272:31209-31212.
Luecke H, Richter H Th, Lanyi J K (1998) Proton Transfer Pathways in Bacteriorhodopsin at 2.3 Angstrom Resolution. Science 280,1934-1937
Michel H, Oesterhelt D. (1980) Three-dimensional crystals of membrane proteins: bacteriorhodopsin.
Proc. Natl. Acad. Sci. USA 77, 1283-1285
Oesterhelt D, Stoeckenius W (1973) Functions of a new photoreceptor membrane. Proc. Natl. Acad
Sci. USA 70, 2853-2857
Oesterhelt, D. 1998. The structure and mechanism of the family of retinal proteins from halophilic
archaea. Curr Opin Struct Bioi 8:489-500.
Ovchinnikov Yu, Abdulaev N, Fergira M, Kiselev A, Lobanov N (1979). The structural basis of the
functioning ofbacteriorhodopsin: an overview. FEBS Lett. 100,219-224
Sass H J, Schachowa I W, Rapp G, Koch M H, Oesterhelt D, Dencher N A, Biildt G (1997) The tertiary
structural changes in bacteriorhodopsin occur between M states: X-ray diffraction and Fourier
transform infrared spectroscopy. EMBO J 16:1484-1491.
Sass H J, Gessenich R, Koch M H, OesterheltD, DencherN A, Biildt G, Rapp G (1998) Evidence for chargecontrolled conformational changes in the photocycle ofbacteriorhodopsin. Biophys J 75:399-405.
Papadopoulos G, Dencher N A, Zaccai G, Biildt G (1990) Water molecules and exchangeable hydrogen
ions at the active centre of bacteriorhodopsin localized by neutron diffraction. J. Mol. BioI. 214,
15-19
Pebay-Peyroula E, Rummel G, Rosenbusch J P, Landau E M (1997) X-ray Structure of Bacteriorhodopsin at 2.5 Angstroms from Microcrystals Grown in Lipidic Cubic Phases. Science 277, 1676-1681
Popot J L, Engelman D M, Gurel 0, Zaccai G. (1989) Tertiary Structure of Bacteriorhodopsin. Positions and Orientations of Helices A and B in the Structure Map Determined by Neutron Diffraction. J. Mol. BioI. 210, 829-847
239
Engelman D M, Zaccai G (1980) Bacteriorhodopsin is an inside-out protein. Proc. Natl. Acad. Sci. USA
77, 5894-5898
Essen L, Siegert R, Lehmann W D, Oesterhelt D (1998) Lipid patches in membrane protein oligomers:
crystal structure of the bacteriorhodopsin-lipid complex. Proc. Nat!. Acac. Sci. USA 95,
11673-11678
Fahmy K, Weidlich 0, Engelhard M, Tittor J, Oesterhelt D, Siebert F (1992) Identification of the Proton
Acceptor of Schiff Base Deprotonation in Bacteriorhodopsin: A Fourier-Transform-Infrared Study
of the Mutant Asp85Glu in its Natural Lipid Environment. Photochem.Photobiol. 56:1073-1083.
Glaeser R M, Baldwin J, Ceska T A, Henderson R (1986) Electron Diffraction Analysis of the M412
Intermediate of Bacteriorhodopsin. Biophys. J. 50, 913-920
Grigorieff N, Ceska T A, Downing K H, Baldwin J M, Henderson R. (1996) Electron-crystallographic
refinement of the structure of bacteriorhodopsin. J. Mol. BioI. 259, 393 -421
Heberle, J. and C. Zscherp. 1996. ATR/FT-IR difference spectroscopy of biological matter with microsecond time resolution. Appl.Spectrosc. 50:588-596.
Heberle J, Biildt G, Koglin E, Rosenbusch J P, Landau E M (l998) Assessing the functionality of a
membrane protein in a three-dimensional crystal. J Mol Bioi 281 :587 - 592.
Henderson R (1975) The Structure of the Purple Membran from Halobacterium halobium: Analysis of
the X-ray Diffraction Pattern. J. Mol. BioI. 93, 123-138
Henderson R, Baldwin J M , Ceska T A, Zemlin F, Beckmann E, Downing K H (1990) Model for the
structure of bacteriorhodopsin based on high-resolution electron cryo-microscopy. J. Mol. BioI.
213, 899-929
Henderson R, Unwin P N T (1975) Three-dimensional model of purple membrane obtained byelectron microscopy. Nature 257, 28-32
Heyn M P, Westerhausen, J, Wallat I and Seiff F (1988) High-sensitivity neutron diffraction of membranes: Location of the Schiff base end of the chromophore of bacteriorhodopsin. Proc. Nat!. Acad.
Sci. USA 85, 2146-2150
Jubb J S, Worcester D L, Crespi H L, Zaccai G (1984) Retinal location in purple membrane of Halobacterium halobium: a neutron diffraction study of membranes labelled in vivo with deuterated retinal. EMBO J. 3, 1455-1461
.
Koch M H J , Dencher N A , Osterhelt D, Pl6hn H J, Rapp G, Biildt G. (l99I) Time-resolved X-ray diffraction study of structural changes associated with the photo cycle of bacteriorhodopsin. EMBO
J.,IO,521-526
Kimura Y, Vassylyev D G , Miyazawa, A, Kidera A, Matsushima M, Mitsuoka K, Murata K, Hirai T,
Fujiyoshi, Y. (1997) Surface ofbacteriorhodopsin revealed by high-resolution electron crystallography. Nature 389, 206-211
Landau E M, Rosenbusch J P (1996) Lipidic cubic phases: A novel concept for the crystallization of
membrane proteins. Proc. Natl. Acad Sci. USA 93,14532-14535
Lanyi J K (1997) Mechanism of ion transport across membranes. Bacteriorhodopsin as a prototype
for proton pumps. J Bioi Chem 272:31209-31212.
Luecke H, Richter H Th, Lanyi J K (1998) Proton Transfer Pathways in Bacteriorhodopsin at 2.3 Angstrom Resolution. Science 280,1934-1937
Michel H, Oesterhelt D. (1980) Three-dimensional crystals of membrane proteins: bacteriorhodopsin.
Proc. Natl. Acad. Sci. USA 77, 1283-1285
Oesterhelt D, Stoeckenius W (1973) Functions of a new photoreceptor membrane. Proc. Natl. Acad
Sci. USA 70, 2853-2857
Oesterhelt, D. 1998. The structure and mechanism of the family of retinal proteins from halophilic
archaea. Curr Opin Struct Bioi 8:489-500.
Ovchinnikov Yu, Abdulaev N, Fergira M, Kiselev A, Lobanov N (1979). The structural basis of the
functioning ofbacteriorhodopsin: an overview. FEBS Lett. 100,219-224
Sass H J, Schachowa I W, Rapp G, Koch M H, Oesterhelt D, Dencher N A, Biildt G (1997) The tertiary
structural changes in bacteriorhodopsin occur between M states: X-ray diffraction and Fourier
transform infrared spectroscopy. EMBO J 16:1484-1491.
Sass H J, Gessenich R, Koch M H, OesterheltD, DencherN A, Biildt G, Rapp G (1998) Evidence for chargecontrolled conformational changes in the photocycle ofbacteriorhodopsin. Biophys J 75:399-405.
Papadopoulos G, Dencher N A, Zaccai G, Biildt G (1990) Water molecules and exchangeable hydrogen
ions at the active centre of bacteriorhodopsin localized by neutron diffraction. J. Mol. BioI. 214,
15-19
Pebay-Peyroula E, Rummel G, Rosenbusch J P, Landau E M (1997) X-ray Structure of Bacteriorhodopsin at 2.5 Angstroms from Microcrystals Grown in Lipidic Cubic Phases. Science 277, 1676-1681
Popot J L, Engelman D M, Gurel 0, Zaccai G. (1989) Tertiary Structure of Bacteriorhodopsin. Positions and Orientations of Helices A and B in the Structure Map Determined by Neutron Diffraction. J. Mol. BioI. 210, 829-847