Cyanogenic glucosides, 125
plants, 229
Cyanoglucosides, 229
Cyanohydrins, 99, 229–233, 335, 337
Cyanolipids, 125, 229
Cyanopyridines, 128, 129
5-Cyanovaleramide, 129
Cyanuric chloride, 380
Cyclases, 409
Cyclodextrin, 379
Cyclohexanone, 191
monooxygenase, 188
Cysteine, 126
Cytochrome P450 175, 176, 199
P450 BM3, 177
Cytochromes, 124
D
DDT, 99
Deactivation, 12, 316, 329
DEAE cellulose, 370
Dealkylation, 4
Deamination, 246, 247
Decarboxylase, 110
Decarboxylation, 247, 331, 359
Deep eutectic solvents, 323–324
Dehalogenases, 257
Dehalogenation, 166, 256–261
Dehydrogenases, 133
ΔΔG
6 ¼ , 16, 19, 75
Dendrimer, 379
De-Novo design, 386–389
2-Deoxyribose-5-phosphate aldolase, 215–216
Dephosphorylation, 105
Deracemization, 46, 123, 124, 154–156,
171–172
Desaturation of carbonyl compounds, 167
Designer bug, 9, 192
Desolvation, 15
Desymmetrization, 62–63, 66, 119, 130–131,
133, 170, 172, 332–333
Detoxification, 26, 119
Dextran, 371
Diallyl carbonate, 346
Dialysis tubing, 377
Diastereoselective hydrolysis, 61–62
reduction, 150–154
Diastereoselectivity, 5
Diclofop, 69
Dielectric constant, 320, 357
Diels-Alder reaction, 4, 388
Digoxin, 244
Dihydrodiol dehydrogenase, 196
Dihydropterine, 157
Dihydro-pyrimidinases, 56
Dihydroxyacetone, 111, 213
phosphate (DHAP), 110, 207, 212, 360, 361
Dihydroxylation, 196–198
Diltiazem, 100
Dimethyl sulfoxide (DMSO), 74
Diol dehydratases, 409
Dioxygenase, 116, 173, 186, 193–194
Dipole moment, 320
Directed evolution, 77, 249
Dismutase, 167
Disproportionation, 199
Distal, 195
Distomer, 5
Disulfide bridges, 12
Dithionite, 135
DNA-shuffling, 78
Docking, 77, 81
Domino-reaction, 358
L-DOPA, 183, 355
Double-sieving, 44
Double-step kinetics, 37
DYKAT, 363
Dynamic, 337–342
resolution, 48–49, 72, 98, 131–133, 151
E
E factor, 101
Electron-withdrawing, 163
Electrostatic catalysis, 16
Enals, 163
Enamine, 205, 216, 235, 250
Enantiocomplementary, 86, 132
Enantioconvergent hydrolysis, 122
Enantioface differentiation, 18, 33
Enantiomer differentiation, 17, 38–40
Enantiomeric ratio, 19, 39
Enantiomer ratio, 40
Enantioselective hydrolysis, 130
inhibition, 102–103
phosphorylation, 111–112
Enantioselectivity, 5
Enantiotopos differentiation, 17–18, 34
Endo-peroxide, 193
Ene-reductases, 133, 161
Enhancers, 75
Enkephalins, 351
Enoate reductases, 161
Enolate, 205
Enol esters, 33, 92
426
Index
plants, 229
Cyanoglucosides, 229
Cyanohydrins, 99, 229–233, 335, 337
Cyanolipids, 125, 229
Cyanopyridines, 128, 129
5-Cyanovaleramide, 129
Cyanuric chloride, 380
Cyclases, 409
Cyclodextrin, 379
Cyclohexanone, 191
monooxygenase, 188
Cysteine, 126
Cytochrome P450 175, 176, 199
P450 BM3, 177
Cytochromes, 124
D
DDT, 99
Deactivation, 12, 316, 329
DEAE cellulose, 370
Dealkylation, 4
Deamination, 246, 247
Decarboxylase, 110
Decarboxylation, 247, 331, 359
Deep eutectic solvents, 323–324
Dehalogenases, 257
Dehalogenation, 166, 256–261
Dehydrogenases, 133
ΔΔG
6 ¼ , 16, 19, 75
Dendrimer, 379
De-Novo design, 386–389
2-Deoxyribose-5-phosphate aldolase, 215–216
Dephosphorylation, 105
Deracemization, 46, 123, 124, 154–156,
171–172
Desaturation of carbonyl compounds, 167
Designer bug, 9, 192
Desolvation, 15
Desymmetrization, 62–63, 66, 119, 130–131,
133, 170, 172, 332–333
Detoxification, 26, 119
Dextran, 371
Diallyl carbonate, 346
Dialysis tubing, 377
Diastereoselective hydrolysis, 61–62
reduction, 150–154
Diastereoselectivity, 5
Diclofop, 69
Dielectric constant, 320, 357
Diels-Alder reaction, 4, 388
Digoxin, 244
Dihydrodiol dehydrogenase, 196
Dihydropterine, 157
Dihydro-pyrimidinases, 56
Dihydroxyacetone, 111, 213
phosphate (DHAP), 110, 207, 212, 360, 361
Dihydroxylation, 196–198
Diltiazem, 100
Dimethyl sulfoxide (DMSO), 74
Diol dehydratases, 409
Dioxygenase, 116, 173, 186, 193–194
Dipole moment, 320
Directed evolution, 77, 249
Dismutase, 167
Disproportionation, 199
Distal, 195
Distomer, 5
Disulfide bridges, 12
Dithionite, 135
DNA-shuffling, 78
Docking, 77, 81
Domino-reaction, 358
L-DOPA, 183, 355
Double-sieving, 44
Double-step kinetics, 37
DYKAT, 363
Dynamic, 337–342
resolution, 48–49, 72, 98, 131–133, 151
E
E factor, 101
Electron-withdrawing, 163
Electrostatic catalysis, 16
Enals, 163
Enamine, 205, 216, 235, 250
Enantiocomplementary, 86, 132
Enantioconvergent hydrolysis, 122
Enantioface differentiation, 18, 33
Enantiomer differentiation, 17, 38–40
Enantiomeric ratio, 19, 39
Enantiomer ratio, 40
Enantioselective hydrolysis, 130
inhibition, 102–103
phosphorylation, 111–112
Enantioselectivity, 5
Enantiotopos differentiation, 17–18, 34
Endo-peroxide, 193
Ene-reductases, 133, 161
Enhancers, 75
Enkephalins, 351
Enoate reductases, 161
Enolate, 205
Enol esters, 33, 92
426
Index