212
A. BETZ
is not only different from its theoretical value but oscillating too. It is in
phase neither with its substrate FDP nor with the products DAP and GAP.
The oscillating value of [D1~D~AP] indicates that there are rhythmically
changing differences between the rates of FDP synthesis and GAP consumption. Some of these metabolites oscillating with respect to their concentrations are given in fig. 6 which shows phase relations as well as ampli[FDP]
tudes. In the lower part of this figure the fluctuations of [DAP] [GAP] are
demonstrated.
[FOP]
[OAP] [GAP]
Fig. 6. Scheme on phase relations and average amplitudes of glycolytic interd · ·
.
h
.
[FDP]
. d'
f
me lates In companson to t e quotient [DAP] [GAP] as an In lcator or
differences in flow rates between the upper and the lower part of the glycolytic
pathway
With respect to the phase relation of glycolytic intermediates and the
fluctuations in the apparent equilibrium constant of aldolase, it is apparent,
that there is one major control point at the PFK reaction and one more