21 Transgenie Animals
335
49. Hilgers KF, Peters J, Veelken R, Sommer M, Rupprecht G, GantenD, Luft FC, Mann
JFE {1992) Increased vascular angiotensin formation in female rats harboring the
mouse Ren-2 gene. Hypertension 19:687-691
50. Bachmann S, Peters J, Engler E, GantenD, Mullins J (1992) Transgenierats carrying
the mouse renin gene - Morphological characterization of a low renin hypertension
model. Kidney Int 41:24-36
51. Fukamizu A, Seo MS, Hatae T, Yokoyama M, Nomura T, Katsuki M, Murakami K
(1989) Tissue-specific expression of the human renin genein transgenic mice. Bioehern Biophys Res Commun 165:826-832
52. Sigmund CD, Jones CA, Kane CM, Wu C, Lang JA, Gross KW {1992) Regulated tissue- and cell-specific expression of the human renin gene in transgenic mice. Circ
Res 70:1070-1079
53. GantenD, Wagner J, Zeh K, Bader M, Michel J-B, Paul M, Zimmermann F, RufP,
Hilgenfeldt U, Ganten U, Kaling M, Bachmann S, Fukamizu A, Mullins JJ, Murakami
K ( 1992) Species specificity of renin kinetics in transgenic rats harboring the human
renin and angiotensinogen genes. Proc Natl Acad Sei USA 89:7806-7810
54. Takahashi S, Fukamizu A, Hasegawa T, Yokoyama M, Nomura T, Katsuki M, Murakami K (1991) Expression of the human angiotensinogen gene in transgenic mice
and transfected cells. Bioehern Biophys Res Commun 180:1103-1109
55. Grant F, Reventos J, Gordon J, Kawabata S, Miller M, Majzoub J {1993) Expression of
the rat arginine vasopressin gene in transgenic mice. Mol Endocrinol 7:659-667
56. Habener JF, Cwikel BJ, Hermann H, Hammer RE, Palmiter RD, Brinster RL (1989)
Metallothionein-vasopressin fusion gene expression in transgenic mice. J Biol
Chem 264:18844-18852
57. Hofmann SL, Russell DW, Brown MS, Goldstein JL, Hammer RE {1988) Overexpression oflow density lipoprotein (LDL) receptor eliminates LDL from plasma in transgenic mice. Science 239:1277-1281
58. Paul M, Zimmermann F, RufP, Zintz M, Maior D, Yanagisawa M {1993) Transgenie
rats expressing the human endothelin-2 gene. Naunyn-Schmiedeberg's Arch Pharmacol 347(Suppl.):R93(Abstract)
59. Jakobovits A, Moore AL, Green LL, Vergara GJ, Maynard-Currie CE, Austin HA,
Klapholz S ( 1993) Germ-line transmission and expression of a human-derived yeast
artificial chromosome. Nature 362:255-258
60. Schedl A, Montoliu L, Kelsey G, Schütz G ( 1993) A yeast artificial chromosome covering the tyrosinase gene confers copy number-dependent expression in transgenic
mice. Nature 362:258-261
61. Choi TK, Hollenbach PW, Pearson BE, Ueda RM, Weddell GN, Kurahara CG, Woodhouse CS, Kay RM, Loring JF {1994) Transgeniemice containing a human heavy
chain immunagiobin in a yeast artificial chromosome. Nature Genet 4:117-123
62. Peterson KR, Clegg CH, Huxley C, Josephson BM, Haugen HS, Furukawa T, Stamatoyanopoulos G ( 1993) Transgeniemice containing a 248-kb yeast artifical chromosome carrying the human beta-globin locus displayproper developmental control
of human globin genes. Proc Natl Acad Sei USA; 90{16):7593 -7
63. Gnirke A, Huxley C, Peterson K, Olson MV ( 1993) Microinjection of intact 200- to
500-kb fragments of YAC DNA into mammalian cells. Genomics 15:659-667
64. Henderson S, Spencer M, Sen A, Kumar C, Siddiqui M, Chien K {1989) Structure,
organization, and expression of the rat cardiac myosin light chain-2 gene: identification of a 250 bp fragment which confers cardiac specific expression. J Biol Chem
264:18142-18148
335
49. Hilgers KF, Peters J, Veelken R, Sommer M, Rupprecht G, GantenD, Luft FC, Mann
JFE {1992) Increased vascular angiotensin formation in female rats harboring the
mouse Ren-2 gene. Hypertension 19:687-691
50. Bachmann S, Peters J, Engler E, GantenD, Mullins J (1992) Transgenierats carrying
the mouse renin gene - Morphological characterization of a low renin hypertension
model. Kidney Int 41:24-36
51. Fukamizu A, Seo MS, Hatae T, Yokoyama M, Nomura T, Katsuki M, Murakami K
(1989) Tissue-specific expression of the human renin genein transgenic mice. Bioehern Biophys Res Commun 165:826-832
52. Sigmund CD, Jones CA, Kane CM, Wu C, Lang JA, Gross KW {1992) Regulated tissue- and cell-specific expression of the human renin gene in transgenic mice. Circ
Res 70:1070-1079
53. GantenD, Wagner J, Zeh K, Bader M, Michel J-B, Paul M, Zimmermann F, RufP,
Hilgenfeldt U, Ganten U, Kaling M, Bachmann S, Fukamizu A, Mullins JJ, Murakami
K ( 1992) Species specificity of renin kinetics in transgenic rats harboring the human
renin and angiotensinogen genes. Proc Natl Acad Sei USA 89:7806-7810
54. Takahashi S, Fukamizu A, Hasegawa T, Yokoyama M, Nomura T, Katsuki M, Murakami K (1991) Expression of the human angiotensinogen gene in transgenic mice
and transfected cells. Bioehern Biophys Res Commun 180:1103-1109
55. Grant F, Reventos J, Gordon J, Kawabata S, Miller M, Majzoub J {1993) Expression of
the rat arginine vasopressin gene in transgenic mice. Mol Endocrinol 7:659-667
56. Habener JF, Cwikel BJ, Hermann H, Hammer RE, Palmiter RD, Brinster RL (1989)
Metallothionein-vasopressin fusion gene expression in transgenic mice. J Biol
Chem 264:18844-18852
57. Hofmann SL, Russell DW, Brown MS, Goldstein JL, Hammer RE {1988) Overexpression oflow density lipoprotein (LDL) receptor eliminates LDL from plasma in transgenic mice. Science 239:1277-1281
58. Paul M, Zimmermann F, RufP, Zintz M, Maior D, Yanagisawa M {1993) Transgenie
rats expressing the human endothelin-2 gene. Naunyn-Schmiedeberg's Arch Pharmacol 347(Suppl.):R93(Abstract)
59. Jakobovits A, Moore AL, Green LL, Vergara GJ, Maynard-Currie CE, Austin HA,
Klapholz S ( 1993) Germ-line transmission and expression of a human-derived yeast
artificial chromosome. Nature 362:255-258
60. Schedl A, Montoliu L, Kelsey G, Schütz G ( 1993) A yeast artificial chromosome covering the tyrosinase gene confers copy number-dependent expression in transgenic
mice. Nature 362:258-261
61. Choi TK, Hollenbach PW, Pearson BE, Ueda RM, Weddell GN, Kurahara CG, Woodhouse CS, Kay RM, Loring JF {1994) Transgeniemice containing a human heavy
chain immunagiobin in a yeast artificial chromosome. Nature Genet 4:117-123
62. Peterson KR, Clegg CH, Huxley C, Josephson BM, Haugen HS, Furukawa T, Stamatoyanopoulos G ( 1993) Transgeniemice containing a 248-kb yeast artifical chromosome carrying the human beta-globin locus displayproper developmental control
of human globin genes. Proc Natl Acad Sei USA; 90{16):7593 -7
63. Gnirke A, Huxley C, Peterson K, Olson MV ( 1993) Microinjection of intact 200- to
500-kb fragments of YAC DNA into mammalian cells. Genomics 15:659-667
64. Henderson S, Spencer M, Sen A, Kumar C, Siddiqui M, Chien K {1989) Structure,
organization, and expression of the rat cardiac myosin light chain-2 gene: identification of a 250 bp fragment which confers cardiac specific expression. J Biol Chem
264:18142-18148