334
ECKART SCHOTT, MARTIN PAUL AND DETLEV GANTEN
33. Clark A, Bessos H, Bisbop J, Brown P, Harris S, Lathe R, McClenaghan M, Prowse C,
Simons J, Whitehaw C, Wilmut I {1989) Expression ofhuman anti-hemophilic factor IX in the milk of transgenic sheep. Bio/Technology 7:487-492
34. Henninghausen L, Ruiz L, Wall R {1990) Transgenie animals:production offoreign
proteins in milk. Curr Opin Biotech 1:74-78
35. Ebert KM, Selgrath JP, DiTullio P, Denman J, Smith TE, Memon MA, Schindler JE"
Monastersky GM, Vitale JA, Gordon K (1991) Transgenie production of a variant of
human tissue-type plasminogen activator in goat milk: Generation of transgenic
goats and analysis of expression. Bio/Technology 9:835-838
36. Wall R, Pursei V, Shamay A, McKnight R, Pittius C, Henninghausen L (1991) Highlevel synthesis of a heterologous milk protein in the mammary gland of transgenic
swine. Proc Natl Acad Sei USA 88:1696-1700
37. Swanson M, Martin M, O'Donnel J, Hoover K, Lago W, Huntress V, Parsons C, Pinkert C, Pilder S, Logan J (1992) Production of functional human hemoglobin in
transgenic swine. Bio/Technology 10:557-559
38. GantenD, Takahashi S, Lindpaintner K, Mullins J (1991) Genetic Basis of Hypertension: The Renin-Angiotensin Paradigm. Hypertension 18:III 109-114
39. Hilbert P, Lindpaintner K, Heckmann JS, Serikawa T, Soubrier F, Dubay C, Cartwright P, DeGouyon B, Julier C, Takahasi S, Vincent M, Ganten D, Georges M, Lathrop GM (1991) Chromosomal mapping oftwo genetic loci associated with bloodpressure regulation in hereditary hypertensive rats. Nature 353:521-529
40. Jacob HJ, Lindpaintner K, Lincoln SE, Kusumi K, Bunker RK, Mao Y-P, GantenD,
Dzau VJ, LanderES (1991) Genetic mapping of a gene causing hypertension in the
stroke-prone spontaneously hypertensive rat. Cell 67:213-224
41. Jeunemaitre X, Soubrier F, Kotelevtsev YV, Lifton RP, Williams CS, Charru A, Hunt
SC, Hopkins PN, Williams RR, Lalouel J-M, Corvol P (1992) Molecular basis ofhuman hypertension: role of angiotensinogen. Cell 71:169-180
42. Cambien F, Poirier 0, Lecerf L, Evans A, Cambou JP, Arveiler D, Luc G, Bard JM,
Bara L, Ricard S, Tiret L, Amouyel P, Alhenc-Gelas F, Soubrier F (1992) Deletion
polymorphism in the gene for angiotensin-converting enzymeisapotent risk factor
for myocardial infarction. Nature 359:641-644
43. Heermann F, Ruppert S, Hummler E, Schütz G {1991) Tyrosinase as a marker for
transgenic mice. Nucleic Acids Res 19:958
44. Naftilan AJ, Williams R, Burt D, Paul M, Pratt RE, Hobart P, Chirgwin J, Dzau VJ
(1989) A lack of genetic linkage of renin gene restriction fragment length polymorphisms with human hypertension. Hypertension 14:614-618
45. Mullins JJ, Peters J, GantenD ( 1990) Fulminanthypertension in transgenic rats harbouring the mouse Ren-2 gene. Nature 344:541-544
46. Bader M, Zhao Y, Sander M, Lee M, Bachmann J, Böhm M, Djavidani B, Peters J,
Mullins JJ, GantenD {1992) Role oftissue renin in the pathophysiology ofhypertension in TGR(mREN2)27 rats. Hypertension 19:681-686
47. Peters J, Münter K, Bader M, Hackenthai E, Mullins JJ, GantenD (1993) Increased
adrenal renin in transgenic hypertensive rats, TGR(mREN2)27, and its regulation by
cAMP, angiotensin li, and calcium. J Clin Invest 91:742-747
48. Böhm, M, Lippoldt A, Wienen W, GantenD, Bader M {1996) Reduction of cardiac
hypertrophy in TGR (mREN2) 27 by angiotensin li receptor blockade. Mol Cell Bioehern; 163-164:217-21
ECKART SCHOTT, MARTIN PAUL AND DETLEV GANTEN
33. Clark A, Bessos H, Bisbop J, Brown P, Harris S, Lathe R, McClenaghan M, Prowse C,
Simons J, Whitehaw C, Wilmut I {1989) Expression ofhuman anti-hemophilic factor IX in the milk of transgenic sheep. Bio/Technology 7:487-492
34. Henninghausen L, Ruiz L, Wall R {1990) Transgenie animals:production offoreign
proteins in milk. Curr Opin Biotech 1:74-78
35. Ebert KM, Selgrath JP, DiTullio P, Denman J, Smith TE, Memon MA, Schindler JE"
Monastersky GM, Vitale JA, Gordon K (1991) Transgenie production of a variant of
human tissue-type plasminogen activator in goat milk: Generation of transgenic
goats and analysis of expression. Bio/Technology 9:835-838
36. Wall R, Pursei V, Shamay A, McKnight R, Pittius C, Henninghausen L (1991) Highlevel synthesis of a heterologous milk protein in the mammary gland of transgenic
swine. Proc Natl Acad Sei USA 88:1696-1700
37. Swanson M, Martin M, O'Donnel J, Hoover K, Lago W, Huntress V, Parsons C, Pinkert C, Pilder S, Logan J (1992) Production of functional human hemoglobin in
transgenic swine. Bio/Technology 10:557-559
38. GantenD, Takahashi S, Lindpaintner K, Mullins J (1991) Genetic Basis of Hypertension: The Renin-Angiotensin Paradigm. Hypertension 18:III 109-114
39. Hilbert P, Lindpaintner K, Heckmann JS, Serikawa T, Soubrier F, Dubay C, Cartwright P, DeGouyon B, Julier C, Takahasi S, Vincent M, Ganten D, Georges M, Lathrop GM (1991) Chromosomal mapping oftwo genetic loci associated with bloodpressure regulation in hereditary hypertensive rats. Nature 353:521-529
40. Jacob HJ, Lindpaintner K, Lincoln SE, Kusumi K, Bunker RK, Mao Y-P, GantenD,
Dzau VJ, LanderES (1991) Genetic mapping of a gene causing hypertension in the
stroke-prone spontaneously hypertensive rat. Cell 67:213-224
41. Jeunemaitre X, Soubrier F, Kotelevtsev YV, Lifton RP, Williams CS, Charru A, Hunt
SC, Hopkins PN, Williams RR, Lalouel J-M, Corvol P (1992) Molecular basis ofhuman hypertension: role of angiotensinogen. Cell 71:169-180
42. Cambien F, Poirier 0, Lecerf L, Evans A, Cambou JP, Arveiler D, Luc G, Bard JM,
Bara L, Ricard S, Tiret L, Amouyel P, Alhenc-Gelas F, Soubrier F (1992) Deletion
polymorphism in the gene for angiotensin-converting enzymeisapotent risk factor
for myocardial infarction. Nature 359:641-644
43. Heermann F, Ruppert S, Hummler E, Schütz G {1991) Tyrosinase as a marker for
transgenic mice. Nucleic Acids Res 19:958
44. Naftilan AJ, Williams R, Burt D, Paul M, Pratt RE, Hobart P, Chirgwin J, Dzau VJ
(1989) A lack of genetic linkage of renin gene restriction fragment length polymorphisms with human hypertension. Hypertension 14:614-618
45. Mullins JJ, Peters J, GantenD ( 1990) Fulminanthypertension in transgenic rats harbouring the mouse Ren-2 gene. Nature 344:541-544
46. Bader M, Zhao Y, Sander M, Lee M, Bachmann J, Böhm M, Djavidani B, Peters J,
Mullins JJ, GantenD {1992) Role oftissue renin in the pathophysiology ofhypertension in TGR(mREN2)27 rats. Hypertension 19:681-686
47. Peters J, Münter K, Bader M, Hackenthai E, Mullins JJ, GantenD (1993) Increased
adrenal renin in transgenic hypertensive rats, TGR(mREN2)27, and its regulation by
cAMP, angiotensin li, and calcium. J Clin Invest 91:742-747
48. Böhm, M, Lippoldt A, Wienen W, GantenD, Bader M {1996) Reduction of cardiac
hypertrophy in TGR (mREN2) 27 by angiotensin li receptor blockade. Mol Cell Bioehern; 163-164:217-21