New Developments in EnantioselectiveBrønsted Acid Catalysis
211
Fig. 1. Representation of the proposed catalytic activation. Aspartate D165 protonates the α-iminoglutarate to form an iminium ion which after hydride transfer
from NADH results in the formation of the amino acid glutamate (left). Active
site of a GDH crystal structure: the glutamate is located in a hydrogen bond
distance from the catalytically essential D165 (right)
Fig. 2. Development of a new Brønsted acid catalyzed transfer hydrogenation
(DPP) appeared to be the best catalyst for this transformation, showing
the highest reaction rate and best yields of the amine formed. Further
211
Fig. 1. Representation of the proposed catalytic activation. Aspartate D165 protonates the α-iminoglutarate to form an iminium ion which after hydride transfer
from NADH results in the formation of the amino acid glutamate (left). Active
site of a GDH crystal structure: the glutamate is located in a hydrogen bond
distance from the catalytically essential D165 (right)
Fig. 2. Development of a new Brønsted acid catalyzed transfer hydrogenation
(DPP) appeared to be the best catalyst for this transformation, showing
the highest reaction rate and best yields of the amine formed. Further