Asymmetric Organocatalysis on a Technical Scale
155
economical attractive synthetic routes to the target molecules, e.g., by
avoiding the use of protecting groups (in particular of those whose subsequent cleavage is difficult).
Acknowledgements. I am grateful for the support of many colleagues during
the preparation of this contribution about large-scale organocatalysis. In this regard I would like to thank Dr. Dave Ager (DSM), Prof. Dr. Karlheinz Drauz, Dr.
Ian Grayson (both Degussa AG), Dr. Charles Fehr (Firmenich), Prof. Dr. Eric
Jacobsen (Harvard University), Prof. Dr. Jürgen Martens (University of Oldenburg), Prof. Dr. Kenji Maruoka (Kyoto University), Prof. Dr. Martin O’Donnell
(University of Illinois), Prof. Dr. Yian Shi (Colorado State University), and Prof.
Dr. Yoshiji Takemoto (Kyoto University) for personal communications. In addition, I would like to thank Prof. Dr. Albrecht Berkessel (University of Cologne),
and Prof. Dr. Heribert Offermanns for many exciting discussions about asymmetric organocatalysis.
References
Ager D (2003) Homogeneous catalysis, from Coors to Heineken. In: 8th International Conference on Organic Process Research and Development,
Conference presentation, Scientific Update Conference, Barcelona, 7–10
September 2003
Ager D, Anderson K, Oblinger E, Shi Y, VanderRoest J (2007) An epoxidation approach to a chiral lactone: application of the Shi-epoxidation. Org
Process Res Dev 11:44
Berkessel A, Gröger H (2005) Asymmetric organocatalysis, from biomimetic
concepts to synthetic applications. VCH-Wiley, Weinheim
Blaser HU, Schmidt E (eds) (2004) Asymmetric catalysis on industrial scale.
Wiley-VCH, Weinheim
Bosch BE (2004) Scalable methods for functionalised chiral alcohols. In: Chiral Europe 2004 Conference Proceedings, Scientific Update Conferences,
Mainz, 14–16 June 2004
Dolling UH, Davis P, Grabowski EJJ (1984) Efficient catalytic asymmetric alkylations, 1. Enantioselective synthesis of (+)-indacrinone via chiral phasetransfer catalysis. J Am Chem Soc 106:446
Drauz K, Waldmann H (eds) (2002) Enzyme catalysis in organic synthesis, vols
1–3, 2nd edn. Wiley-VCH, Weinheim
Eder U, Sauer G, Wiechert R (1971a) New type of asymmetric cyclization to
optically active steroid CD partial structures. Angew Chem Int Ed Engl
10:496
155
economical attractive synthetic routes to the target molecules, e.g., by
avoiding the use of protecting groups (in particular of those whose subsequent cleavage is difficult).
Acknowledgements. I am grateful for the support of many colleagues during
the preparation of this contribution about large-scale organocatalysis. In this regard I would like to thank Dr. Dave Ager (DSM), Prof. Dr. Karlheinz Drauz, Dr.
Ian Grayson (both Degussa AG), Dr. Charles Fehr (Firmenich), Prof. Dr. Eric
Jacobsen (Harvard University), Prof. Dr. Jürgen Martens (University of Oldenburg), Prof. Dr. Kenji Maruoka (Kyoto University), Prof. Dr. Martin O’Donnell
(University of Illinois), Prof. Dr. Yian Shi (Colorado State University), and Prof.
Dr. Yoshiji Takemoto (Kyoto University) for personal communications. In addition, I would like to thank Prof. Dr. Albrecht Berkessel (University of Cologne),
and Prof. Dr. Heribert Offermanns for many exciting discussions about asymmetric organocatalysis.
References
Ager D (2003) Homogeneous catalysis, from Coors to Heineken. In: 8th International Conference on Organic Process Research and Development,
Conference presentation, Scientific Update Conference, Barcelona, 7–10
September 2003
Ager D, Anderson K, Oblinger E, Shi Y, VanderRoest J (2007) An epoxidation approach to a chiral lactone: application of the Shi-epoxidation. Org
Process Res Dev 11:44
Berkessel A, Gröger H (2005) Asymmetric organocatalysis, from biomimetic
concepts to synthetic applications. VCH-Wiley, Weinheim
Blaser HU, Schmidt E (eds) (2004) Asymmetric catalysis on industrial scale.
Wiley-VCH, Weinheim
Bosch BE (2004) Scalable methods for functionalised chiral alcohols. In: Chiral Europe 2004 Conference Proceedings, Scientific Update Conferences,
Mainz, 14–16 June 2004
Dolling UH, Davis P, Grabowski EJJ (1984) Efficient catalytic asymmetric alkylations, 1. Enantioselective synthesis of (+)-indacrinone via chiral phasetransfer catalysis. J Am Chem Soc 106:446
Drauz K, Waldmann H (eds) (2002) Enzyme catalysis in organic synthesis, vols
1–3, 2nd edn. Wiley-VCH, Weinheim
Eder U, Sauer G, Wiechert R (1971a) New type of asymmetric cyclization to
optically active steroid CD partial structures. Angew Chem Int Ed Engl
10:496