New Concepts for Organocatalysis
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Scheme 11. Phosphoric acid catalysis pioneered by Akiyama and Terada
et al. 2004; also see Uraguchi et al. 2005; Terada et al. 2005) demonstrated, in pioneering studies, that relatively strong chiral binaphtholderived phosphoric acids are efficient and highly enantioselective catalysts for addition reactions to aldimines (Scheme 11).
3.1
Catalytic Asymmetric Pictet–Spengler Reaction
The Pictet–Spengler reaction (Pictet and Spengler 1911; Tatsui 1928) is
an important acid-catalyzed transformation frequently used in the laboratory as well as by various organisms for the synthesis of tetrahydro-β-
15
Scheme 11. Phosphoric acid catalysis pioneered by Akiyama and Terada
et al. 2004; also see Uraguchi et al. 2005; Terada et al. 2005) demonstrated, in pioneering studies, that relatively strong chiral binaphtholderived phosphoric acids are efficient and highly enantioselective catalysts for addition reactions to aldimines (Scheme 11).
3.1
Catalytic Asymmetric Pictet–Spengler Reaction
The Pictet–Spengler reaction (Pictet and Spengler 1911; Tatsui 1928) is
an important acid-catalyzed transformation frequently used in the laboratory as well as by various organisms for the synthesis of tetrahydro-β-