Glycosyl Trichloroacetimidates
3.2
515
⊡ Scheme 45
5.10 O-Glycosyl Trichloroacetimidates of N ,O- and S,O-Halfacetals
Not only O,O-halfacetals but also N,O-, and S,O-halfacetals have successfully been transformed into trichloroacetimidate derivatives [325,326]. Thus carbohydrates with sulfur
in the ring have been successfully transformed into O-glycosyl trichloroacetimidates and
employed in glycosylation reactions by M. Hashimoto et al. [327,328] and by H. Hashimoto
et al. [329,330]. Thy glycosyl donors could be readily obtained by base-catalyzed trichloroacetonitrile addition to the anomeric hydroxy group and glycosylation yields under standard
conditions were generally very good.
3.2
515
⊡ Scheme 45
5.10 O-Glycosyl Trichloroacetimidates of N ,O- and S,O-Halfacetals
Not only O,O-halfacetals but also N,O-, and S,O-halfacetals have successfully been transformed into trichloroacetimidate derivatives [325,326]. Thus carbohydrates with sulfur
in the ring have been successfully transformed into O-glycosyl trichloroacetimidates and
employed in glycosylation reactions by M. Hashimoto et al. [327,328] and by H. Hashimoto
et al. [329,330]. Thy glycosyl donors could be readily obtained by base-catalyzed trichloroacetonitrile addition to the anomeric hydroxy group and glycosylation yields under standard
conditions were generally very good.