Reactions at Oxygen Atoms
2.1
151
⊡ Scheme 57
Cyclic di-t-butysilylene as protecting group
⊡ Scheme 58
Examples of di-t-butysilylene-directed α-galactosylation
2.6 Phosphorylation Reactions
Phosphate esters play an important role in a wide variety of structurally diverse natural and
biologically active compounds such as glycolipids, nucleic acids, nucleotides, proteins, coenzymes, steroids, and in particular carbohydrates. Introduction of a phosphate group essentially
changes the physical and chemical properties of the parent molecule, resulting in changes to
the polarization and intermolecular bonding characteristics of that molecule. Given the importance of this functional group it is not surprising that many methods have been developed for
the phosphorylation of alcohol functions [348,349]. Both chemical and enzymic methods are
available for the synthesis of specific phosphates.
2.1
151
⊡ Scheme 57
Cyclic di-t-butysilylene as protecting group
⊡ Scheme 58
Examples of di-t-butysilylene-directed α-galactosylation
2.6 Phosphorylation Reactions
Phosphate esters play an important role in a wide variety of structurally diverse natural and
biologically active compounds such as glycolipids, nucleic acids, nucleotides, proteins, coenzymes, steroids, and in particular carbohydrates. Introduction of a phosphate group essentially
changes the physical and chemical properties of the parent molecule, resulting in changes to
the polarization and intermolecular bonding characteristics of that molecule. Given the importance of this functional group it is not surprising that many methods have been developed for
the phosphorylation of alcohol functions [348,349]. Both chemical and enzymic methods are
available for the synthesis of specific phosphates.