144 Marine Macro- and Microalgae: An Overview
Spavieri, J., A. Allmendinger, M. Kaiser, R. Casey, S. Hingley-Wilson, A. Lalvani, M.D. Guiry, G. Blunden and D. Tasdemir.
2010a. Antimycobacterial, antiprotozoal and cytotoxic potential of twenty-one brown algae (Phaeophyceae) from British
and Irish waters. Phytother. Res. 24(11): 1724–9.
Spavieri, J., M. Kaiser, R. Casey, S. Hingley-Wilson, A. Lalvani, G. Blunden and D. Tasdemir. 2010b. Antiprotozoal,
antimycobacterial and cytotoxic potential of some British green algae. Phytother. Res. 24: 1095–1098.
Stirk, W., D. Reinecke and J. van Staden. 2007. Seasonal variation in antifungal, antibacterial and acetylcholinesterase activity
in seven South African seaweeds. J. Appl. Phycol. 19: 271–276.
Suárez, Y., L. González, A. Cuadrado, M. Berciano, M. Lafarga and A. Muñoz. 2003. Kahalalide F, a new marine-derived
compound, induces oncosis in human prostate and breast cancer cells. Mol. Cancer Ther. 2: 863–872.
Suffness, M. and J. Douros. 1982. Current status of the NCI plant and animal product program J. Nat. Prod. 45: 1–14.
Suganthy, N., S. Karutha Pandian and K. Pandima Devi. 2010. Neuroprotective effect of seaweeds inhabiting South Indian
coastal area (Hare Island, Gulf of Mannar marine biosphere reserve): Cholinesterase inhibitory effect of Hypnea valentiae
and Ulva reticulata. Neurosci. Lett. 468: 216–219.
Süzgeç-Selçuk, S., A.H. Meriçli, K.C. Güven, M. Kaiser, R. Casey, S. Hingley-Wilson, A. Lalvani and D. Tasdemir. 2010.
Evaluation of Turkish seaweeds for antiprotozoal, antimycobacterial and cytotoxic activities. Phytother. Res. 25: 778–83.
Suzuki, T., A. Furusaki, T. Matsumoto, A. Kato, Y. Lmanaka and E. Kurosawa. 1985. Teurilene and thyrsiferyl 23 acetate,
meso and remarkably cytotoxic compounds from the marine red alga Laurencia obtuse. Tetrahedron Lett. 26: 1329–1332.
Tang, H.-F., Y.-H. Yi, X.-S. Yao, Q.-Z. Xu, S.-Y. Zhang and H.-W. Lin. 2002. Bioactive steroids from the brown alga Sargassum
carpophyllum. J. Asian Nat. Prod. Res. 4: 95–101.
Tanzi, R.E. 2005. The synaptic Abeta hypothesis of Alzheimer disease. Nat. Neurosci. 8: 977–979.
Tempone, A.G., C. Martins de Oliveira and R.G. Berlinck. 2011. Current approaches to discover marine antileishmanial
natural products. Planta Med. 77: 572–85.
Topcu, G., Z. Aydogmus, S. Imre, A.C. Gören, J.M. Pezzuto, J.A. Clement and D.G. Kingston. 2003. Brominated sesquiterpenes
from the red alga Laurencia obtusa. J. Nat. Prod. 66: 1505–8.
Tringali, C., M. Prattellia and G. Nicols. 1984. Structure and conformation of new diterpenes based on the dolabellane skeleton
from Dictyota species. Tetrahedron 40: 703–799.
Tseng, Z.C. and Z.J. Chang. 1984. Chinese seaweeds herbal medicine. Hydrobiologia. 116/117: 152–154.
Umemura, K., K. Yanase, M. Suzuki, K. Okutani, T. Yamori and T. Andoh. 2003. Inhibition of DNA topoisomerases I and II, and
growth inhibition of human cancer cell lines by a marine microalgal polysaccharide. Biochem. Pharmacol. 66: 481–487.
Urdiales, J.L., P. Morata, I.N. De Castro and F. Sanchez-Jimenez. 1996. Anti-proliferative effect of dehydrodidemnin B (DDB),
a depsipeptide isolated from Mediterranean tunicates. Cancer Lett. 102: 31–37.
Varela, J., C. Vizetto-Duarte, L. Custódio, L. Barreira and F. Albericio. 2013. Marine peptides and proteins with cytotoxic
and antitumoral properties. pp. 407–430. In: S.-K. Kim (ed.). Marine Proteins and Peptides: Development, Biological
Activities, and Industrial Perspectives. Wiley-Blackwell, Chichester, UK.
Veiga-Santos, P., K.J. Pelizzaro-Rocha, A.O. Santos, T. Ueda-Nakamura, B.P. Dias-Filho, S.O. Silva, D.B. Sudatti,
E.M. Bianco, R.C. Pereira and C.V. Nakamura. 2010. In vitro anti-trypanosomal activity of elatol isolated from red
seaweed Laurencia dendroidea. Parasitology 14: 1–10.
Vihinen, P. and V.M. Kähäri. 2002. Matrix metalloproteinases in cancer: prognostic markers and therapeutic targets. Int. J.
Cancer 99: 157–166.
Vonthron-Sénécheau, C., M. Kaiser, I. Devambez, A. Vastel, I. Mussio and A.M. Rusig. 2011. Antiprotozoal activities of
organic extracts from french marine seaweeds. Mar. Drugs. 9: 922–933.
Weinreb, O., S. Mandel, O. Bar-Am and T. Amit. 2011. Iron-chelating backbone coupled with monoamine oxidase inhibitory
moiety as novel pluripotential therapeutic agents for Alzheimer’s disease: A tribute to Moussa Youdim. J. Neural Transm.
118: 479–492.
Whitehouse, P.J., J.C. Hedreen, C.L. White and D.L. Price. 1983. Basal forebrain neurons in the dementia of Parkinson
disease. Ann. Neurol. 13: 243–248.
Wijesekara, I., R. Pangestuti and S. Kim. 2011. Biological activities and potential health benefits of sulfated polysaccharides
derived from marine algae. Carbohyd. Polym. 84: 14–21.
Williams, P., A. Sorribas and M.J. Howes. 2011. Natural products as a source of Alzheimer’s drug leads. Nat. Prod. Rep. 28:
48–77.
Wimo, A., B. Winblad, H. Aguero-Torres and E. von Strauss. 2003. The magnitude of dementia occurrence in the world.
Alzheimer Dis. Assoc. Disord. 17: 63–67.
[WHO] World Health Organization. 2008. The global burden of disease: 2004 update. WHO press, Geneva: 160pp.
[WHO] World Health Organization. 2010a. Control of the leishmaniases. Report of a meeting of the WHO Expert Committee
on the Control of Leishmaniases. WHO Technical Report Series n.º 949. WHO Press, Geneva: 186pp.
[WHO] World Health Organization. 2010b. Working to overcome the global impact of neglected tropical diseases. First WHO
report on neglected tropical diseases. WHO Press, Geneva: 184pp.
[WHO] World Health Organization. 2011. World malaria report: 2011. WHO Press, Geneva: 278pp.
[WHO] World Health Organization. 2012a. Fact sheet on Trypanosomiasis, Human African (sleeping sickness) - N.º 259.
[WHO] World Health Organization. 2012b. Fact sheet on Chagas disease (American trypanosomiasis) - N.º 340.
Wright, A.D. and G.M. König. 1996. Antimalarial activity: the search for marine-derived natural products with selective
antimalarial activity? J. Nat. Prod. 59: 710–716.
Spavieri, J., A. Allmendinger, M. Kaiser, R. Casey, S. Hingley-Wilson, A. Lalvani, M.D. Guiry, G. Blunden and D. Tasdemir.
2010a. Antimycobacterial, antiprotozoal and cytotoxic potential of twenty-one brown algae (Phaeophyceae) from British
and Irish waters. Phytother. Res. 24(11): 1724–9.
Spavieri, J., M. Kaiser, R. Casey, S. Hingley-Wilson, A. Lalvani, G. Blunden and D. Tasdemir. 2010b. Antiprotozoal,
antimycobacterial and cytotoxic potential of some British green algae. Phytother. Res. 24: 1095–1098.
Stirk, W., D. Reinecke and J. van Staden. 2007. Seasonal variation in antifungal, antibacterial and acetylcholinesterase activity
in seven South African seaweeds. J. Appl. Phycol. 19: 271–276.
Suárez, Y., L. González, A. Cuadrado, M. Berciano, M. Lafarga and A. Muñoz. 2003. Kahalalide F, a new marine-derived
compound, induces oncosis in human prostate and breast cancer cells. Mol. Cancer Ther. 2: 863–872.
Suffness, M. and J. Douros. 1982. Current status of the NCI plant and animal product program J. Nat. Prod. 45: 1–14.
Suganthy, N., S. Karutha Pandian and K. Pandima Devi. 2010. Neuroprotective effect of seaweeds inhabiting South Indian
coastal area (Hare Island, Gulf of Mannar marine biosphere reserve): Cholinesterase inhibitory effect of Hypnea valentiae
and Ulva reticulata. Neurosci. Lett. 468: 216–219.
Süzgeç-Selçuk, S., A.H. Meriçli, K.C. Güven, M. Kaiser, R. Casey, S. Hingley-Wilson, A. Lalvani and D. Tasdemir. 2010.
Evaluation of Turkish seaweeds for antiprotozoal, antimycobacterial and cytotoxic activities. Phytother. Res. 25: 778–83.
Suzuki, T., A. Furusaki, T. Matsumoto, A. Kato, Y. Lmanaka and E. Kurosawa. 1985. Teurilene and thyrsiferyl 23 acetate,
meso and remarkably cytotoxic compounds from the marine red alga Laurencia obtuse. Tetrahedron Lett. 26: 1329–1332.
Tang, H.-F., Y.-H. Yi, X.-S. Yao, Q.-Z. Xu, S.-Y. Zhang and H.-W. Lin. 2002. Bioactive steroids from the brown alga Sargassum
carpophyllum. J. Asian Nat. Prod. Res. 4: 95–101.
Tanzi, R.E. 2005. The synaptic Abeta hypothesis of Alzheimer disease. Nat. Neurosci. 8: 977–979.
Tempone, A.G., C. Martins de Oliveira and R.G. Berlinck. 2011. Current approaches to discover marine antileishmanial
natural products. Planta Med. 77: 572–85.
Topcu, G., Z. Aydogmus, S. Imre, A.C. Gören, J.M. Pezzuto, J.A. Clement and D.G. Kingston. 2003. Brominated sesquiterpenes
from the red alga Laurencia obtusa. J. Nat. Prod. 66: 1505–8.
Tringali, C., M. Prattellia and G. Nicols. 1984. Structure and conformation of new diterpenes based on the dolabellane skeleton
from Dictyota species. Tetrahedron 40: 703–799.
Tseng, Z.C. and Z.J. Chang. 1984. Chinese seaweeds herbal medicine. Hydrobiologia. 116/117: 152–154.
Umemura, K., K. Yanase, M. Suzuki, K. Okutani, T. Yamori and T. Andoh. 2003. Inhibition of DNA topoisomerases I and II, and
growth inhibition of human cancer cell lines by a marine microalgal polysaccharide. Biochem. Pharmacol. 66: 481–487.
Urdiales, J.L., P. Morata, I.N. De Castro and F. Sanchez-Jimenez. 1996. Anti-proliferative effect of dehydrodidemnin B (DDB),
a depsipeptide isolated from Mediterranean tunicates. Cancer Lett. 102: 31–37.
Varela, J., C. Vizetto-Duarte, L. Custódio, L. Barreira and F. Albericio. 2013. Marine peptides and proteins with cytotoxic
and antitumoral properties. pp. 407–430. In: S.-K. Kim (ed.). Marine Proteins and Peptides: Development, Biological
Activities, and Industrial Perspectives. Wiley-Blackwell, Chichester, UK.
Veiga-Santos, P., K.J. Pelizzaro-Rocha, A.O. Santos, T. Ueda-Nakamura, B.P. Dias-Filho, S.O. Silva, D.B. Sudatti,
E.M. Bianco, R.C. Pereira and C.V. Nakamura. 2010. In vitro anti-trypanosomal activity of elatol isolated from red
seaweed Laurencia dendroidea. Parasitology 14: 1–10.
Vihinen, P. and V.M. Kähäri. 2002. Matrix metalloproteinases in cancer: prognostic markers and therapeutic targets. Int. J.
Cancer 99: 157–166.
Vonthron-Sénécheau, C., M. Kaiser, I. Devambez, A. Vastel, I. Mussio and A.M. Rusig. 2011. Antiprotozoal activities of
organic extracts from french marine seaweeds. Mar. Drugs. 9: 922–933.
Weinreb, O., S. Mandel, O. Bar-Am and T. Amit. 2011. Iron-chelating backbone coupled with monoamine oxidase inhibitory
moiety as novel pluripotential therapeutic agents for Alzheimer’s disease: A tribute to Moussa Youdim. J. Neural Transm.
118: 479–492.
Whitehouse, P.J., J.C. Hedreen, C.L. White and D.L. Price. 1983. Basal forebrain neurons in the dementia of Parkinson
disease. Ann. Neurol. 13: 243–248.
Wijesekara, I., R. Pangestuti and S. Kim. 2011. Biological activities and potential health benefits of sulfated polysaccharides
derived from marine algae. Carbohyd. Polym. 84: 14–21.
Williams, P., A. Sorribas and M.J. Howes. 2011. Natural products as a source of Alzheimer’s drug leads. Nat. Prod. Rep. 28:
48–77.
Wimo, A., B. Winblad, H. Aguero-Torres and E. von Strauss. 2003. The magnitude of dementia occurrence in the world.
Alzheimer Dis. Assoc. Disord. 17: 63–67.
[WHO] World Health Organization. 2008. The global burden of disease: 2004 update. WHO press, Geneva: 160pp.
[WHO] World Health Organization. 2010a. Control of the leishmaniases. Report of a meeting of the WHO Expert Committee
on the Control of Leishmaniases. WHO Technical Report Series n.º 949. WHO Press, Geneva: 186pp.
[WHO] World Health Organization. 2010b. Working to overcome the global impact of neglected tropical diseases. First WHO
report on neglected tropical diseases. WHO Press, Geneva: 184pp.
[WHO] World Health Organization. 2011. World malaria report: 2011. WHO Press, Geneva: 278pp.
[WHO] World Health Organization. 2012a. Fact sheet on Trypanosomiasis, Human African (sleeping sickness) - N.º 259.
[WHO] World Health Organization. 2012b. Fact sheet on Chagas disease (American trypanosomiasis) - N.º 340.
Wright, A.D. and G.M. König. 1996. Antimalarial activity: the search for marine-derived natural products with selective
antimalarial activity? J. Nat. Prod. 59: 710–716.