Marine Algal Bioactivities 123
Pacifenol
Rhodophyta
Rhodomelaceae
Laurencia claviformis Inhibition of LTB4 and TXB2,
modulation of COX pathway and
inhibition of phospholipase A
2
D’ Orazio et al. 2012
Rhodophyta
Rhodomelaceae
Laurencia filiformis Inhibition of LTB4 and TXB2,
modulation of COX pathway and
inhibition of phospholipase A
2
D’ Orazio et al. 2012
Prepacifenol
Rhodophyta
Rhodomelaceae
Laurencia filiformis Inhibition of LTB4 and TXB2,
modulation of COX pathway and
inhibition of phospholipase A
2
D’ Orazio et al. 2012
1
ConA – concanavalin A; COX – cyclooxygenase; CPO – carrageenan permeability oedema; FMLP – formyl-Met-Leu-Phe; IFN-γ – interferon-gamma; IL-1β – interleukin-1-β; IL-6 –
interleukin-6; iNOS – inducible nitric oxide synthase; IкB – inhibitory protein B; LPS – lipopolysaccharide; LTB4 – leukotriene B4; MAPKs – mitogen activated protein kinases; NF-кB
– nuclear factor-kappaB; NO – nitric oxide; PGE2 – prostaglandin E2; PMNS – human polymorphonuclear leukocytes; TNF-α - tumour necrosis factor – alpha; TXB2 – thromboxane B2.
Pacifenol
Rhodophyta
Rhodomelaceae
Laurencia claviformis Inhibition of LTB4 and TXB2,
modulation of COX pathway and
inhibition of phospholipase A
2
D’ Orazio et al. 2012
Rhodophyta
Rhodomelaceae
Laurencia filiformis Inhibition of LTB4 and TXB2,
modulation of COX pathway and
inhibition of phospholipase A
2
D’ Orazio et al. 2012
Prepacifenol
Rhodophyta
Rhodomelaceae
Laurencia filiformis Inhibition of LTB4 and TXB2,
modulation of COX pathway and
inhibition of phospholipase A
2
D’ Orazio et al. 2012
1
ConA – concanavalin A; COX – cyclooxygenase; CPO – carrageenan permeability oedema; FMLP – formyl-Met-Leu-Phe; IFN-γ – interferon-gamma; IL-1β – interleukin-1-β; IL-6 –
interleukin-6; iNOS – inducible nitric oxide synthase; IкB – inhibitory protein B; LPS – lipopolysaccharide; LTB4 – leukotriene B4; MAPKs – mitogen activated protein kinases; NF-кB
– nuclear factor-kappaB; NO – nitric oxide; PGE2 – prostaglandin E2; PMNS – human polymorphonuclear leukocytes; TNF-α - tumour necrosis factor – alpha; TXB2 – thromboxane B2.