antibacterial, antifungal, and antiviral substances respectively isolated from marine
bacteria and fungi.
An active search is also under way for antitumor substances in marine bacteria
and fungi. As growth inhibition activity testing can be conducted relatively easily
with cultured tumor cells, metabolites from marine microorganisms are also being
actively screened. The number of new antitumor substances found to date in marine
bacteria and algae is even greater than the number of antimicrobial substances.
Tables 11.6 and 11.7 provide a list of new antitumor substances respectively isolated from marine bacteria and fungi.
Tables 11.8 and 11.9 list anti-inflammatory and other bioactive substances
isolated from marine bacteria and fungi, respectively. In addition to
anti-inflammatory substances, searches for enzyme inhibitors and antioxidants have
also been reported (Namikoshi 2005).
Table 11.6 New antitumor substances isolated from marine bacteria
Compound
Bacterium responsible
Source
Abratubolactam C
Streptomyes sp.
Mollusks
Agrochelin
Agrobacterium sp.
Sea squirts
Altemicidin
Streptomyces sioyaensis
Sea mud
Alterramide A
Alteromonas sp.
Sponges
Aureoverticillactam
Streptomyces aureoverticillatus
Sea mud
Bisucaberin
Alteromonas haloplanktis
Sea mud
Chandrananimycin A–C
Actinomadura sp.
Sea mud
Cyclomarin A–C
Spreptomyces sp.
Sea mud
-d-Indomycinone
Spreptomyces sp.
Sea mud
-c-Indomycinone
Spreptomyces sp.
Sea mud
Halichoblelide
Spreptomyces hygroscopicus
Fish
Halichomycin
Spreptomyces hygroscopicus
Fish
Halobacillin
Bacillus sp.
Sea mud
Homocereulide
Bacillus cereus
Mollusks
Lagunapyrone A–C
Actinomycete
Sea mud
Lomaiviticin AÁB
Micromonospora lamaivitiensis
Sea squirts
Neomarinones, Marinones
Streptomyces sp.
Sea mud
Octalctin AÁB
Pelagiobacter sp.
Coral
Pelagiomicin A–C
Salinospora sp.
Seaweed
Salinosporamide A
Micromonospora marina
Sea mud
Thiocoraline
Streptomyces sp.
Coral
Caprolactones
Micromonospora sp.
Sea mud
Staurosporins
Streptomyces sp.
Sponges
Indoles
Invertebrates
11.3 Bioactive Substances from Marine Microorganisms
393
bacteria and fungi.
An active search is also under way for antitumor substances in marine bacteria
and fungi. As growth inhibition activity testing can be conducted relatively easily
with cultured tumor cells, metabolites from marine microorganisms are also being
actively screened. The number of new antitumor substances found to date in marine
bacteria and algae is even greater than the number of antimicrobial substances.
Tables 11.6 and 11.7 provide a list of new antitumor substances respectively isolated from marine bacteria and fungi.
Tables 11.8 and 11.9 list anti-inflammatory and other bioactive substances
isolated from marine bacteria and fungi, respectively. In addition to
anti-inflammatory substances, searches for enzyme inhibitors and antioxidants have
also been reported (Namikoshi 2005).
Table 11.6 New antitumor substances isolated from marine bacteria
Compound
Bacterium responsible
Source
Abratubolactam C
Streptomyes sp.
Mollusks
Agrochelin
Agrobacterium sp.
Sea squirts
Altemicidin
Streptomyces sioyaensis
Sea mud
Alterramide A
Alteromonas sp.
Sponges
Aureoverticillactam
Streptomyces aureoverticillatus
Sea mud
Bisucaberin
Alteromonas haloplanktis
Sea mud
Chandrananimycin A–C
Actinomadura sp.
Sea mud
Cyclomarin A–C
Spreptomyces sp.
Sea mud
-d-Indomycinone
Spreptomyces sp.
Sea mud
-c-Indomycinone
Spreptomyces sp.
Sea mud
Halichoblelide
Spreptomyces hygroscopicus
Fish
Halichomycin
Spreptomyces hygroscopicus
Fish
Halobacillin
Bacillus sp.
Sea mud
Homocereulide
Bacillus cereus
Mollusks
Lagunapyrone A–C
Actinomycete
Sea mud
Lomaiviticin AÁB
Micromonospora lamaivitiensis
Sea squirts
Neomarinones, Marinones
Streptomyces sp.
Sea mud
Octalctin AÁB
Pelagiobacter sp.
Coral
Pelagiomicin A–C
Salinospora sp.
Seaweed
Salinosporamide A
Micromonospora marina
Sea mud
Thiocoraline
Streptomyces sp.
Coral
Caprolactones
Micromonospora sp.
Sea mud
Staurosporins
Streptomyces sp.
Sponges
Indoles
Invertebrates
11.3 Bioactive Substances from Marine Microorganisms
393