500
S. Biswas et al.
the highly complex and highly variable data sets—are all avenues in which remarkable progress is being demonstrated. today’s clinical pathology suffers from several
limitations in the areas of diagnosis, prognosis as well as treatments of diseases.
Ft-IR histopathology has the potential of providing some advantages over common
clinical histopathological techniques in all these areas of need.
References
1. Bhargava R (2012) Infrared spectroscopic imaging: the next generation. Appl Spectrosc
66(10):1091–120
2. Bhargava R (oct (2007) towards a practical Fourier transform infrared chemical imaging
protocol for cancer histopathology. Anal Bioanal Chem 389(4):1155–1169
3. Srinivasan g, Bhargava R (Jul 2007) Fourier transform-infrared spectroscopic imaging: the
emerging evolution from a microscopy tool to a cancer imaging modality. Spectroscopy
22(7):30
4. Levin IW, Bhargava R (5 may 2005) Fourier transform infrared vibrational spectroscopic imaging: integrating microscopy and molecular recognition. Annu Rev Phys Chem 56(1):429–474
5. griffiths PR, de haseth JA (2007) Fourier transform infrared spectrometry. Wiley, hoboken
6. Jackson m (2004) Biomolecules to biodiagnostics: spectroscopy does it all. Faraday discuss
126:1–18
7. Jackson m, Sowa mg, mantsch hh (oct 1997) Infrared spectroscopy: a new frontier in
medicine. Biophys Chem 68(1–3):109–125
8. Diem M, Romeo M, Boydston-White S, Miljković M, Matthäus C (2004) A decade of vibrational micro-spectroscopy of human cells and tissue (1994-2004). Analyst 129(10):880–885
9. martin FL, Kelly Jg, Llabjani v, martin-hirsch PL, Patel II, trevisan J, Fullwood NJ, Walsh
mJ (2010) distinguishing cell types or populations based on the computational analysis of
their infrared spectra. Nat Prot 5:1748–1760
10. diem m, griffiths PR, Chalmers Jm (eds) (2008) vibrational spectroscopy for medical diagnosis. Wiley, Chichester
11. Fernandez dC, Bhargava R, hewitt Sm, Levin IW (2005) Infrared spectroscopic imaging for
histopathologic recognition. Nat Biotechnol 23(4):469–474
12. Colarusso P, Kidder Lh, Levin IW, Fraser JC, Arens JF, Lewis EN (1998) Infrared spectroscopic imaging: from planetary to cellular systems. Appl Spectrosc 52:106a–120a
13. Walsh mJ, Reddy RK, Bhargava R (2012) Label-free biomedical imaging with mid-Infrared
microspectroscopy. IEEE J Sel top Quant 18:1502–1513
14. dumas P, Jamin N, teillaud JL, miller Lm, Beccard B (2004) Imaging capabilities of synchrotron infrared microspectroscopy. Faraday discuss 126:289–302. discussion 303–311
15. miller Lm, dumas P (Jul 2006) Chemical imaging of biological tissue with synchrotron
infrared light. Bio chim Bio phys Acta 1758(7):846–857
16. dumas P, Sockalingum gd, Sule-Suso J (Jan 2007) Adding synchrotron radiation to infrared
microspectroscopy: what’s new in biomedical applications? trends Biotechnol 25(1):40–44
17. hirschmugl CJ, gough Km (may 2012) Fourier transform infrared spectrochemical imaging: review of design and applications with a focal plane array and multiple beam synchrotron radiation source. Appl Spectrosc 66(5):475–491
18. Bhargava R, Levin IW (eds) (2005) Spectrochemical analysis using infrared multichannel
detectors. Blackwell Publishing, oxford, pp 56–84
19. Lewis EN, treado PJ, Reeder RC, Story gm, dowrey AE, marcott C, Levin IW (1995)
Fourier transform spectroscopic imaging using an infrared focal-plane array detector. Anal
Chem 67:3377–3381
S. Biswas et al.
the highly complex and highly variable data sets—are all avenues in which remarkable progress is being demonstrated. today’s clinical pathology suffers from several
limitations in the areas of diagnosis, prognosis as well as treatments of diseases.
Ft-IR histopathology has the potential of providing some advantages over common
clinical histopathological techniques in all these areas of need.
References
1. Bhargava R (2012) Infrared spectroscopic imaging: the next generation. Appl Spectrosc
66(10):1091–120
2. Bhargava R (oct (2007) towards a practical Fourier transform infrared chemical imaging
protocol for cancer histopathology. Anal Bioanal Chem 389(4):1155–1169
3. Srinivasan g, Bhargava R (Jul 2007) Fourier transform-infrared spectroscopic imaging: the
emerging evolution from a microscopy tool to a cancer imaging modality. Spectroscopy
22(7):30
4. Levin IW, Bhargava R (5 may 2005) Fourier transform infrared vibrational spectroscopic imaging: integrating microscopy and molecular recognition. Annu Rev Phys Chem 56(1):429–474
5. griffiths PR, de haseth JA (2007) Fourier transform infrared spectrometry. Wiley, hoboken
6. Jackson m (2004) Biomolecules to biodiagnostics: spectroscopy does it all. Faraday discuss
126:1–18
7. Jackson m, Sowa mg, mantsch hh (oct 1997) Infrared spectroscopy: a new frontier in
medicine. Biophys Chem 68(1–3):109–125
8. Diem M, Romeo M, Boydston-White S, Miljković M, Matthäus C (2004) A decade of vibrational micro-spectroscopy of human cells and tissue (1994-2004). Analyst 129(10):880–885
9. martin FL, Kelly Jg, Llabjani v, martin-hirsch PL, Patel II, trevisan J, Fullwood NJ, Walsh
mJ (2010) distinguishing cell types or populations based on the computational analysis of
their infrared spectra. Nat Prot 5:1748–1760
10. diem m, griffiths PR, Chalmers Jm (eds) (2008) vibrational spectroscopy for medical diagnosis. Wiley, Chichester
11. Fernandez dC, Bhargava R, hewitt Sm, Levin IW (2005) Infrared spectroscopic imaging for
histopathologic recognition. Nat Biotechnol 23(4):469–474
12. Colarusso P, Kidder Lh, Levin IW, Fraser JC, Arens JF, Lewis EN (1998) Infrared spectroscopic imaging: from planetary to cellular systems. Appl Spectrosc 52:106a–120a
13. Walsh mJ, Reddy RK, Bhargava R (2012) Label-free biomedical imaging with mid-Infrared
microspectroscopy. IEEE J Sel top Quant 18:1502–1513
14. dumas P, Jamin N, teillaud JL, miller Lm, Beccard B (2004) Imaging capabilities of synchrotron infrared microspectroscopy. Faraday discuss 126:289–302. discussion 303–311
15. miller Lm, dumas P (Jul 2006) Chemical imaging of biological tissue with synchrotron
infrared light. Bio chim Bio phys Acta 1758(7):846–857
16. dumas P, Sockalingum gd, Sule-Suso J (Jan 2007) Adding synchrotron radiation to infrared
microspectroscopy: what’s new in biomedical applications? trends Biotechnol 25(1):40–44
17. hirschmugl CJ, gough Km (may 2012) Fourier transform infrared spectrochemical imaging: review of design and applications with a focal plane array and multiple beam synchrotron radiation source. Appl Spectrosc 66(5):475–491
18. Bhargava R, Levin IW (eds) (2005) Spectrochemical analysis using infrared multichannel
detectors. Blackwell Publishing, oxford, pp 56–84
19. Lewis EN, treado PJ, Reeder RC, Story gm, dowrey AE, marcott C, Levin IW (1995)
Fourier transform spectroscopic imaging using an infrared focal-plane array detector. Anal
Chem 67:3377–3381