18 Near-Infrared Spectroscopy in the Pharmaceutical Industry
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0
100
200
300
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500
600
700
800
Time (min)
0
0.1
0.2
0.3
0.4
0.5
0.6
0.7
0.8
0.9
1
Conversion
Fig. 18.2 Predicted concentration profiles. ( ) myristic acid; (- -) isopropyl myristate; (—)
isopropanol; ( ): acid concentrations obtained by titration. (Reproduced with permission from [36])
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8:00
9:00
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Concentration [mass %]
Time [h])
-5
0
5
10
15
20
25
Grignard (NIR)
Compound A (NIR)
Grignard (HPLC)
Compound A (HPLC)
Addition of compound A
Aging time
Fig. 18.3 Compound formation and consumption during a highly exothermic reaction (Reproduced
with permission from [38])