84
J. Knapik-Kowalczuk et al.
a
b
Fig. 22 Panel a shows temperature dependence of the relaxation times of the fully amorphous FLU
+ 13 wt.% of KVA sample (grey stars) as well as the samples after non-isothermal (red hexagons)
and isothermal crystallization (black circle). Temperature dependence of τ α in the supercooled
liquid has been described by VFT equations (solid lines). Panel b presents the X-ray diffraction
patterns for FLU + 41 wt.% of KVA at T = 298 K. The absence of sharp Bragg peaks indicates
the full amorphousness of the sample. Up-to-date result was provided by K. Jurkiewicz according
to the procedure described in ref. [33]
What is more both isothermal and non-isothermal dielectric measurements
used to determine drug-excipient solubility limit are not limited to the drugpolymer mixtures. Analogous measurements were conducted in drug-drug systems
as presented in case of FLU in a binary mixture with BIC.[36] What indicates on the
universal potential of this method.
Acknowledgements The authors are grateful for the financial support received within the Project
No. 2015/16/W/NZ7/00404 (SYMFONIA 3) from the National Science Centre, Poland.
References
1. Shah VP, Amidon GL (2014) AAPS J 16:894
2. Lee VH, Hussain AS, Yu LX, Amidon GL, Polli JE, Zhao H, Mehta MU, Conner DP, Shah
VP, Lesko LJ, Chen M (2002) Pharm Res 19
3. Thayer AM (2010) Chem Eng News Arch 88:13
4. Babu NJ, Nangia A (2011) Cryst Growth Des 11:2662
5. Laitinen R, Löbmann K, Strachan CJ, Grohganz H, Rades T (2013) Int J Pharm 453:65
6. Kawakami K (2012) Adv Drug Deliv Rev 64:480
7. Amidon GL, Lennernäs H, Shah VP, Crison JR (1995) Pharm Res 12:413
8. Forster A, Hempenstall J, Rades T (2001) J Pharm Pharmacol 53:303
9. Hancock BC, Parks M (2000) Pharm Res 17:397
10. Murdande SB, Pikal MJ, Shanker RM, Bogner RH (2010) J Pharm Sci 99:1254
11. Shah N, Sandhu H, Choi DS, Chokshi H, Malick AW (2014) Amorphous solid dispersions
12. Descamps M (2016) Disordered Pharmaceutical Materials
J. Knapik-Kowalczuk et al.
a
b
Fig. 22 Panel a shows temperature dependence of the relaxation times of the fully amorphous FLU
+ 13 wt.% of KVA sample (grey stars) as well as the samples after non-isothermal (red hexagons)
and isothermal crystallization (black circle). Temperature dependence of τ α in the supercooled
liquid has been described by VFT equations (solid lines). Panel b presents the X-ray diffraction
patterns for FLU + 41 wt.% of KVA at T = 298 K. The absence of sharp Bragg peaks indicates
the full amorphousness of the sample. Up-to-date result was provided by K. Jurkiewicz according
to the procedure described in ref. [33]
What is more both isothermal and non-isothermal dielectric measurements
used to determine drug-excipient solubility limit are not limited to the drugpolymer mixtures. Analogous measurements were conducted in drug-drug systems
as presented in case of FLU in a binary mixture with BIC.[36] What indicates on the
universal potential of this method.
Acknowledgements The authors are grateful for the financial support received within the Project
No. 2015/16/W/NZ7/00404 (SYMFONIA 3) from the National Science Centre, Poland.
References
1. Shah VP, Amidon GL (2014) AAPS J 16:894
2. Lee VH, Hussain AS, Yu LX, Amidon GL, Polli JE, Zhao H, Mehta MU, Conner DP, Shah
VP, Lesko LJ, Chen M (2002) Pharm Res 19
3. Thayer AM (2010) Chem Eng News Arch 88:13
4. Babu NJ, Nangia A (2011) Cryst Growth Des 11:2662
5. Laitinen R, Löbmann K, Strachan CJ, Grohganz H, Rades T (2013) Int J Pharm 453:65
6. Kawakami K (2012) Adv Drug Deliv Rev 64:480
7. Amidon GL, Lennernäs H, Shah VP, Crison JR (1995) Pharm Res 12:413
8. Forster A, Hempenstall J, Rades T (2001) J Pharm Pharmacol 53:303
9. Hancock BC, Parks M (2000) Pharm Res 17:397
10. Murdande SB, Pikal MJ, Shanker RM, Bogner RH (2010) J Pharm Sci 99:1254
11. Shah N, Sandhu H, Choi DS, Chokshi H, Malick AW (2014) Amorphous solid dispersions
12. Descamps M (2016) Disordered Pharmaceutical Materials