442
5 Laser Specklometer, Speckle-Optical Diagnostics and Laser …
capillaries [172, 221]. This effect of microcirculation system on laser impact is associated with photoactivated suppression of tone of smooth myocytes in large arterioles
[172], the stabilization of the histohematogenous barrier and functional state of the
wall of micro- and macrovessels, including its endothelium, reduction of regional
vascular resistance, the development of collaterals, that improves the tropism of
denervated tissues [173] and creates favorable conditions for regeneration of nerve
fibers in the early stages of restoration and regenerative process [176].
Speckle-optical studies of skin microhemodynamics found that the use of
intravenous laser blood irradiation creates in patients with compressive–ischemic
neuropathy of the peripheral nerves more optimal, compared with the control group,
conditions of blood supply to damaged tissues, causing an increase in the power
spectrum and the increase in the frequency f of the speckle intensity fluctuation
field scattered by the skin. By the medicamentous therapy, only a tendency to increase
the average frequency f and reduction in power spectrum is noted.
The activating effect of intravenous laser blood irradiation on the power spectrum
of intensity fluctuations of the speckle-field of the limb muscles with compressive–
ischemic neuropathy of the peripheral nerves and the contralateral limb is revealed,
whereas medicament therapy by activating the muscle tone of healthy limbs does
not have positive effect in the early stages of study on the functional state of muscle
fibers innervated by the nerve. It is established that both methods of treatment do
not cause positive changes of the amplitude parameters of contractile function of the
myons, but optimize their frequency characteristics.
Further, the study of the diagnostic features of methods of coherent optics made
it possible to identify another speckle-optical indicator for an objective assessment
of the cutaneous microcirculation, and in particular the ratio of the area of small
regions around the two selected frequencies of the spectrum, such as the ratio of the
area under the spectral curve in the frequency range of 600–640 Hz to the area under
the spectral curve in the frequency range of 40–80 Hz. It is shown experimentally
that the study of blood flow to this parameter was very sensitive and can be used as
a criterion for the degree of violation of microhemocirculatory processes.
Based on experimental studies, there was installed the effectiveness of lowlevel radiation of He–Ne and semiconductor laser in ischemic injury and neurorraphy peripheral nerves, which helps to activate the immune processes, improves
microcirculation of tissues by increasing the degree of oxygenation of the blood
and improves oxygen function. A comparative analysis of various methods of lowintensity laser irradiation showed higher efficiency of intravenous laser blood irradiation as compared with the experimental data of laser puncture in immunological
studies.
By speckle-optical study of the biomechanical parameters of the functional
activity of the muscles and skin blood flow conditions, there was revealed a positive
therapeutic effect of intravenous laser blood irradiation in patients with neurorraphy
and compressive–ischemic neuropathy of the peripheral nerves, resulting in normalization of the cutaneous microcirculation in the damaged tissues, improving the state
of tonic muscle fibers. However, this positive effect influences only some of the
speckle-optical indices of contractile properties.
5 Laser Specklometer, Speckle-Optical Diagnostics and Laser …
capillaries [172, 221]. This effect of microcirculation system on laser impact is associated with photoactivated suppression of tone of smooth myocytes in large arterioles
[172], the stabilization of the histohematogenous barrier and functional state of the
wall of micro- and macrovessels, including its endothelium, reduction of regional
vascular resistance, the development of collaterals, that improves the tropism of
denervated tissues [173] and creates favorable conditions for regeneration of nerve
fibers in the early stages of restoration and regenerative process [176].
Speckle-optical studies of skin microhemodynamics found that the use of
intravenous laser blood irradiation creates in patients with compressive–ischemic
neuropathy of the peripheral nerves more optimal, compared with the control group,
conditions of blood supply to damaged tissues, causing an increase in the power
spectrum and the increase in the frequency f of the speckle intensity fluctuation
field scattered by the skin. By the medicamentous therapy, only a tendency to increase
the average frequency f and reduction in power spectrum is noted.
The activating effect of intravenous laser blood irradiation on the power spectrum
of intensity fluctuations of the speckle-field of the limb muscles with compressive–
ischemic neuropathy of the peripheral nerves and the contralateral limb is revealed,
whereas medicament therapy by activating the muscle tone of healthy limbs does
not have positive effect in the early stages of study on the functional state of muscle
fibers innervated by the nerve. It is established that both methods of treatment do
not cause positive changes of the amplitude parameters of contractile function of the
myons, but optimize their frequency characteristics.
Further, the study of the diagnostic features of methods of coherent optics made
it possible to identify another speckle-optical indicator for an objective assessment
of the cutaneous microcirculation, and in particular the ratio of the area of small
regions around the two selected frequencies of the spectrum, such as the ratio of the
area under the spectral curve in the frequency range of 600–640 Hz to the area under
the spectral curve in the frequency range of 40–80 Hz. It is shown experimentally
that the study of blood flow to this parameter was very sensitive and can be used as
a criterion for the degree of violation of microhemocirculatory processes.
Based on experimental studies, there was installed the effectiveness of lowlevel radiation of He–Ne and semiconductor laser in ischemic injury and neurorraphy peripheral nerves, which helps to activate the immune processes, improves
microcirculation of tissues by increasing the degree of oxygenation of the blood
and improves oxygen function. A comparative analysis of various methods of lowintensity laser irradiation showed higher efficiency of intravenous laser blood irradiation as compared with the experimental data of laser puncture in immunological
studies.
By speckle-optical study of the biomechanical parameters of the functional
activity of the muscles and skin blood flow conditions, there was revealed a positive
therapeutic effect of intravenous laser blood irradiation in patients with neurorraphy
and compressive–ischemic neuropathy of the peripheral nerves, resulting in normalization of the cutaneous microcirculation in the damaged tissues, improving the state
of tonic muscle fibers. However, this positive effect influences only some of the
speckle-optical indices of contractile properties.