Chapter 2
Bio-microelectromechanical Systems
(BioMEMS) in Bio-sensing
Applications-Colorimetric Detection
Strategies
Michelle Alejandra Espinosa-Hernandez, Sofia Reveles-Huizar,
and Samira Hosseini
2.1 Introduction
One of the most well-known analytic methods of detection is based on quantifying the
UV–vis absorption or reflection, also known as colorimetric (Li et al. 2019a). Colorimetric biosensors are simple, rapid, disposable, and low-cost (Zhang et al. 2006; Li
et al. 2019b). Additionally, they enable the signal readout with color changes or even
directly judged by the naked eye (Li et al. 2019b). For MEMS, specially BioMEMS,
these qualities enable medical exams to become more accessible and user friendly.
Likewise, biological processes can be carefully assessed due to the concentration of
the color which is commonly directly proportional to the concentration of the analyte
of interest (Aldewachi et al. 2018). In this chapter, we review the latest advancement
of paper-based, microfluidics and alternative BioMEMS that operate based upon
the principles of colorimetric detection. A comprehensive review of these devices is
presented and summarized in Table 2.1.
2.2 Colorimetric Detection Strategy
The detection method known as colorimetric determines the presence and concentration of an analyte through comparing the color changes of a solution. This method
is based on the quantification of the change in the absorbance of the solution due to
the concentration of the analyte of interest. This relationship can be described using
the Beer-Lambert equation, which relates the concentration to the absorption, with
the light path remaining constant (Wilson 2013). When white light passes through a
M. A. Espinosa-Hernandez · S. Reveles-Huizar · S. Hosseini (B)
School of Engineering and Sciences, Tecnologico de Monterrey, Monterrey, Mexico
e-mail: samira.hosseini@tec.mx
© The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer
Nature Singapore Pte Ltd. 2021
S. Hosseini et al., BioMEMS, Lecture Notes in Bioengineering,
https://doi.org/10.1007/978-981-15-6382-9_2
21
Bio-microelectromechanical Systems
(BioMEMS) in Bio-sensing
Applications-Colorimetric Detection
Strategies
Michelle Alejandra Espinosa-Hernandez, Sofia Reveles-Huizar,
and Samira Hosseini
2.1 Introduction
One of the most well-known analytic methods of detection is based on quantifying the
UV–vis absorption or reflection, also known as colorimetric (Li et al. 2019a). Colorimetric biosensors are simple, rapid, disposable, and low-cost (Zhang et al. 2006; Li
et al. 2019b). Additionally, they enable the signal readout with color changes or even
directly judged by the naked eye (Li et al. 2019b). For MEMS, specially BioMEMS,
these qualities enable medical exams to become more accessible and user friendly.
Likewise, biological processes can be carefully assessed due to the concentration of
the color which is commonly directly proportional to the concentration of the analyte
of interest (Aldewachi et al. 2018). In this chapter, we review the latest advancement
of paper-based, microfluidics and alternative BioMEMS that operate based upon
the principles of colorimetric detection. A comprehensive review of these devices is
presented and summarized in Table 2.1.
2.2 Colorimetric Detection Strategy
The detection method known as colorimetric determines the presence and concentration of an analyte through comparing the color changes of a solution. This method
is based on the quantification of the change in the absorbance of the solution due to
the concentration of the analyte of interest. This relationship can be described using
the Beer-Lambert equation, which relates the concentration to the absorption, with
the light path remaining constant (Wilson 2013). When white light passes through a
M. A. Espinosa-Hernandez · S. Reveles-Huizar · S. Hosseini (B)
School of Engineering and Sciences, Tecnologico de Monterrey, Monterrey, Mexico
e-mail: samira.hosseini@tec.mx
© The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer
Nature Singapore Pte Ltd. 2021
S. Hosseini et al., BioMEMS, Lecture Notes in Bioengineering,
https://doi.org/10.1007/978-981-15-6382-9_2
21