Chapter 8
Bio-microelectromechanical Systems
(BioMEMS) in Bio-sensing
Applications-Electrochemiluminescence
Detection Strategies
Ana Sofia Cerda-Kipper and Samira Hosseini
8.1 Introduction
The biosensors that operate based upon electrochemical detection method incorporate an electrochemical transducer, which mediates the generation of a measurable electrical signal (Li et al. 2019). Electrochemiluminescence (ECL) was used to
monitor enzymatic reactions, and for analysis of various species (Richter 2008) and
analytes (Ju et al. 2017), as well as in different biosensor applications (Roda 2017).
ECL-based immunosensing combines the unique advantages of highly specific
immunoreaction and convenient ECL biosensing offering a promising method for
analyte measurement (Ju et al. 2017). ECL labels have distinct advantages over
other detection methods as they are sensitive, nonhazardous, and inexpensive. These
labels contribute to the diagnostic of a particular element, are linear over a wide
range, and incorporate a relatively inexpensive equipment with modest operation
(Richter 2008; Ju et al. 2017; Roda 2017; Zhang 2019). Additionally, ECL-based
biosensors are simple, rapid, and inexpensive in comparison to other methods, such
as surface-enhanced Raman spectroscopy (SERS) (Li et al. 2019). ECL detection
technique has a wide range of applications in multiple fields including environmental monitoring, clinical diagnosis, food safety, biodiagnosis, and pharmacology
(Zhang 2019; Farokhi-Fard et al. 2019). Moreover, due to its efficiency, considerably low detection limit, reducing the LOD, simplicity, and cost-effectiveness, ECL
has become an excellent technique for development of bio-microelectromechanical
systems (BioMEMS) for point-of-care (POC) or extreme point of care (EPOC)
(Socorro-Leránoz et al. 2019; Blair and Corrigan 2019).
A. S. Cerda-Kipper · S. Hosseini (B)
School of Engineering and Sciences, Tecnologico de Monterrey, Monterrey, Mexico
e-mail: samira.hosseini@tec.mx
© The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer
Nature Singapore Pte Ltd. 2021
S. Hosseini et al., BioMEMS, Lecture Notes in Bioengineering,
https://doi.org/10.1007/978-981-15-6382-9_8
161
Bio-microelectromechanical Systems
(BioMEMS) in Bio-sensing
Applications-Electrochemiluminescence
Detection Strategies
Ana Sofia Cerda-Kipper and Samira Hosseini
8.1 Introduction
The biosensors that operate based upon electrochemical detection method incorporate an electrochemical transducer, which mediates the generation of a measurable electrical signal (Li et al. 2019). Electrochemiluminescence (ECL) was used to
monitor enzymatic reactions, and for analysis of various species (Richter 2008) and
analytes (Ju et al. 2017), as well as in different biosensor applications (Roda 2017).
ECL-based immunosensing combines the unique advantages of highly specific
immunoreaction and convenient ECL biosensing offering a promising method for
analyte measurement (Ju et al. 2017). ECL labels have distinct advantages over
other detection methods as they are sensitive, nonhazardous, and inexpensive. These
labels contribute to the diagnostic of a particular element, are linear over a wide
range, and incorporate a relatively inexpensive equipment with modest operation
(Richter 2008; Ju et al. 2017; Roda 2017; Zhang 2019). Additionally, ECL-based
biosensors are simple, rapid, and inexpensive in comparison to other methods, such
as surface-enhanced Raman spectroscopy (SERS) (Li et al. 2019). ECL detection
technique has a wide range of applications in multiple fields including environmental monitoring, clinical diagnosis, food safety, biodiagnosis, and pharmacology
(Zhang 2019; Farokhi-Fard et al. 2019). Moreover, due to its efficiency, considerably low detection limit, reducing the LOD, simplicity, and cost-effectiveness, ECL
has become an excellent technique for development of bio-microelectromechanical
systems (BioMEMS) for point-of-care (POC) or extreme point of care (EPOC)
(Socorro-Leránoz et al. 2019; Blair and Corrigan 2019).
A. S. Cerda-Kipper · S. Hosseini (B)
School of Engineering and Sciences, Tecnologico de Monterrey, Monterrey, Mexico
e-mail: samira.hosseini@tec.mx
© The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer
Nature Singapore Pte Ltd. 2021
S. Hosseini et al., BioMEMS, Lecture Notes in Bioengineering,
https://doi.org/10.1007/978-981-15-6382-9_8
161