Chapter 7
Bio-microelectromechanical Systems
(BioMEMS) in Bio-sensing
Applications-Biochemiluminescence
Detection Strategies
Ana Sofia Cerda-Kipper and Samira Hosseini
7.1 Introduction
Luminescence is the light produced by compounds that are catalyzed by enzymes,
while chemiluminescence (CL) is when the compounds undergoes specific oxidation
reactions (Davies et al. 2003). Biochemiluminescence (BL-CL) is one of the most
common emissions produced by a living organism and based upon the principles of
CL (Roda et al. 2004). Th coupled BL-CL enzymatic reactions is used to increase
the detection sensitivity in comparison to conventional colorimetric or fluorescence
methods (Roda et al. 2014).
Smartphone-based devices are known for their ability to incorporate colorimetric,
fluorescence, chemiluminescence, bioluminescence, and label-free detection strategies (Shahvar et al. 2018). Smart devices are considered to be the evolutionary additions to BioMEMS devices for development of point-of-care devices (Roda et al.
2014). Smart BioMEMS play a leading role in recreational activities, healthcare
delivery (e.g. perform tests outside clinical laboratories) and environmental monitoring (e.g. detection of different analytes in soil and water) due to their multifunctional capabilities, imaging, and computing power, as well as their portability, affordability, simplicity, and accessibility (Shahvar et al. 2018). A fundamental advantage
of BioMEMS technology is that it has the potential to offer an “all-in-one device”.
The built-in functions of smartphones can be further expanded through accessories
that enable the sensing of different types biomarkers and analytes (Roda et al. 2014).
A. S. Cerda-Kipper · S. Hosseini (B)
School of Engineering and Sciences, Tecnologico de Monterrey, Monterrey, Mexico
e-mail: samira.hosseini@tec.mx
© The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer
Nature Singapore Pte Ltd. 2021
S. Hosseini et al., BioMEMS, Lecture Notes in Bioengineering,
https://doi.org/10.1007/978-981-15-6382-9_7
153
Bio-microelectromechanical Systems
(BioMEMS) in Bio-sensing
Applications-Biochemiluminescence
Detection Strategies
Ana Sofia Cerda-Kipper and Samira Hosseini
7.1 Introduction
Luminescence is the light produced by compounds that are catalyzed by enzymes,
while chemiluminescence (CL) is when the compounds undergoes specific oxidation
reactions (Davies et al. 2003). Biochemiluminescence (BL-CL) is one of the most
common emissions produced by a living organism and based upon the principles of
CL (Roda et al. 2004). Th coupled BL-CL enzymatic reactions is used to increase
the detection sensitivity in comparison to conventional colorimetric or fluorescence
methods (Roda et al. 2014).
Smartphone-based devices are known for their ability to incorporate colorimetric,
fluorescence, chemiluminescence, bioluminescence, and label-free detection strategies (Shahvar et al. 2018). Smart devices are considered to be the evolutionary additions to BioMEMS devices for development of point-of-care devices (Roda et al.
2014). Smart BioMEMS play a leading role in recreational activities, healthcare
delivery (e.g. perform tests outside clinical laboratories) and environmental monitoring (e.g. detection of different analytes in soil and water) due to their multifunctional capabilities, imaging, and computing power, as well as their portability, affordability, simplicity, and accessibility (Shahvar et al. 2018). A fundamental advantage
of BioMEMS technology is that it has the potential to offer an “all-in-one device”.
The built-in functions of smartphones can be further expanded through accessories
that enable the sensing of different types biomarkers and analytes (Roda et al. 2014).
A. S. Cerda-Kipper · S. Hosseini (B)
School of Engineering and Sciences, Tecnologico de Monterrey, Monterrey, Mexico
e-mail: samira.hosseini@tec.mx
© The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer
Nature Singapore Pte Ltd. 2021
S. Hosseini et al., BioMEMS, Lecture Notes in Bioengineering,
https://doi.org/10.1007/978-981-15-6382-9_7
153