6 Bio-microelectromechanical Systems (BioMEMS) …
149
significantly improved for the ultrasensitive detection of target pathogens in clinical samples, indicating that their method has significant promise for the early stage
diagnosis of pathogenic infections (Yang et al. 2015).
Summary
Chemiluminescence (CL) has become a competitive detection method in comparison
to other techniques including fluorescence and colorimetric as it is naturally generated
with higher signal intensity and has higher durability for readout. By integrating
CL within miniaturized BioMEMS, other beneficial features were added to such
hybrid systems including compact device size, small sample volume consumption,
portability, and cost-effectiveness. Enzymes are commonly incorporated or coupled
with CL to amplify the detection signals or to multiply detectable products. The
combination of BioMEMS and CL allows fabrication of systems that are rapid for
their applications in POC or EPOC. The current chapter provides an insight on some
of the latest advancements in integration of BioMEMS and CL detection method for
biosensing applications.
References
Algaar F et al (2015) Fiber-optic immunosensor for detection of crimean-congo hemorrhagic fever
IgG antibodies in patients. Anal Chem 87(16):8394–8398. https://doi.org/10.1021/acs.analchem.
5b01728
Bridle H (2014) Optical detection technologies for waterborne pathogens. In: Waterborne pathogens.
Elsevier, pp 119–145
Chang KW, Li J, Yang CH, Shiesh SC, Bin Lee G (2015) An integrated microfluidic system for
measurement of glycated hemoglobin Levels by using an aptamer-antibody assay on magnetic
beads. Biosens Bioelectron 68: 397–403. doi: https://doi.org/10.1016/j.bios.2015.01.027
Conger NG et al (2015) Health care response to CCHF in US soldier and nosocomial transmission
to health care providers, Germany, 2009. Emerg Infect Dis 21(1):23–31. https://doi.org/10.3201/
eid2101.141413
Guan W, Zhang C, Liu F, Liu M (2015) Chemiluminescence detection for microfluidic cloth-based
analytical devices (μCADs). Biosens Bioelectron 72:114–120. https://doi.org/10.1016/J.BIOS.
2015.04.064
He Y, Liu D, He X, Cui H (2011) One-pot synthesis of luminol functionalized silver nanoparticles
with chemiluminescence activity for ultrasensitive DNA sensing. Chem Commun 47(38):10692–
10694. https://doi.org/10.1039/c1cc14389a
Henares TG, Mizutani F, Hisamoto H (2008) Current development in microfluidic immunosensing
chip. Anal Chim Acta 611(1):17–30. https://doi.org/10.1016/J.ACA.2008.01.064
Hu B et al (2017) Lab on a Chip An automated and portable microfluidic chemiluminescence
immunoassay for quantitative detection of biomarkers. 17: 2225. doi: https://doi.org/10.1039/c7l
c00249a
Li Z et al (2011) Polymerase chain reaction coupling with magnetic nanoparticles-based biotinavidin system for amplification of chemiluminescent detection signals of nucleic acid. J Nanosci
Nanotechnol 11(2):1074–1078. https://doi.org/10.1166/jnn.2011.3061
Li H, Liu C, Wang D, Zhang C (2017) Chemiluminescence cloth-based glucose test sensors
(CCGTSs): a new class of chemiluminescence glucose sensors ARTICLEINFO. Biosens
Bioelectron 91:268–275. https://doi.org/10.1016/j.bios.2016.12.004
149
significantly improved for the ultrasensitive detection of target pathogens in clinical samples, indicating that their method has significant promise for the early stage
diagnosis of pathogenic infections (Yang et al. 2015).
Summary
Chemiluminescence (CL) has become a competitive detection method in comparison
to other techniques including fluorescence and colorimetric as it is naturally generated
with higher signal intensity and has higher durability for readout. By integrating
CL within miniaturized BioMEMS, other beneficial features were added to such
hybrid systems including compact device size, small sample volume consumption,
portability, and cost-effectiveness. Enzymes are commonly incorporated or coupled
with CL to amplify the detection signals or to multiply detectable products. The
combination of BioMEMS and CL allows fabrication of systems that are rapid for
their applications in POC or EPOC. The current chapter provides an insight on some
of the latest advancements in integration of BioMEMS and CL detection method for
biosensing applications.
References
Algaar F et al (2015) Fiber-optic immunosensor for detection of crimean-congo hemorrhagic fever
IgG antibodies in patients. Anal Chem 87(16):8394–8398. https://doi.org/10.1021/acs.analchem.
5b01728
Bridle H (2014) Optical detection technologies for waterborne pathogens. In: Waterborne pathogens.
Elsevier, pp 119–145
Chang KW, Li J, Yang CH, Shiesh SC, Bin Lee G (2015) An integrated microfluidic system for
measurement of glycated hemoglobin Levels by using an aptamer-antibody assay on magnetic
beads. Biosens Bioelectron 68: 397–403. doi: https://doi.org/10.1016/j.bios.2015.01.027
Conger NG et al (2015) Health care response to CCHF in US soldier and nosocomial transmission
to health care providers, Germany, 2009. Emerg Infect Dis 21(1):23–31. https://doi.org/10.3201/
eid2101.141413
Guan W, Zhang C, Liu F, Liu M (2015) Chemiluminescence detection for microfluidic cloth-based
analytical devices (μCADs). Biosens Bioelectron 72:114–120. https://doi.org/10.1016/J.BIOS.
2015.04.064
He Y, Liu D, He X, Cui H (2011) One-pot synthesis of luminol functionalized silver nanoparticles
with chemiluminescence activity for ultrasensitive DNA sensing. Chem Commun 47(38):10692–
10694. https://doi.org/10.1039/c1cc14389a
Henares TG, Mizutani F, Hisamoto H (2008) Current development in microfluidic immunosensing
chip. Anal Chim Acta 611(1):17–30. https://doi.org/10.1016/J.ACA.2008.01.064
Hu B et al (2017) Lab on a Chip An automated and portable microfluidic chemiluminescence
immunoassay for quantitative detection of biomarkers. 17: 2225. doi: https://doi.org/10.1039/c7l
c00249a
Li Z et al (2011) Polymerase chain reaction coupling with magnetic nanoparticles-based biotinavidin system for amplification of chemiluminescent detection signals of nucleic acid. J Nanosci
Nanotechnol 11(2):1074–1078. https://doi.org/10.1166/jnn.2011.3061
Li H, Liu C, Wang D, Zhang C (2017) Chemiluminescence cloth-based glucose test sensors
(CCGTSs): a new class of chemiluminescence glucose sensors ARTICLEINFO. Biosens
Bioelectron 91:268–275. https://doi.org/10.1016/j.bios.2016.12.004