378
P. Martínez-Vázquez et al.
Fig. 24.2 a Flow diagram procedure of DoA monitors. General scheme approach to estimate the
patient’s depth of anaesthesia level. b Example of the time evolution of anaesthetic drugs Ce for
a patient during an intraoperative procedure with propofol and remifentanil. c Density Spectral
Array (DSA) for the whole intraoperative procedure, representing the power spectral density every
second. d Time evolution of two pEEG derived indices for sedation, BIS and qCON, the BSR and
a probability of response to noxious stimulation index qNOX. LOC—Loss of consciousness
24.4 Depth of Anaesthesia Monitoring Validation
There are several methodologies to validate any DoA index. Without considering
technical aspects between different definitions and implementations, one of the
validations rely on the correlation between the index and the hypnotic drug Ce.
Figure 24.3a, shows the relation between the qCON index and the propofol Ce concentration for n = 660 patients in gynecologic surgery who underwent intravenous
anesthesia with remifentanil, giving a high Prediction probability (Pk) value of 0.825
P. Martínez-Vázquez et al.
Fig. 24.2 a Flow diagram procedure of DoA monitors. General scheme approach to estimate the
patient’s depth of anaesthesia level. b Example of the time evolution of anaesthetic drugs Ce for
a patient during an intraoperative procedure with propofol and remifentanil. c Density Spectral
Array (DSA) for the whole intraoperative procedure, representing the power spectral density every
second. d Time evolution of two pEEG derived indices for sedation, BIS and qCON, the BSR and
a probability of response to noxious stimulation index qNOX. LOC—Loss of consciousness
24.4 Depth of Anaesthesia Monitoring Validation
There are several methodologies to validate any DoA index. Without considering
technical aspects between different definitions and implementations, one of the
validations rely on the correlation between the index and the hypnotic drug Ce.
Figure 24.3a, shows the relation between the qCON index and the propofol Ce concentration for n = 660 patients in gynecologic surgery who underwent intravenous
anesthesia with remifentanil, giving a high Prediction probability (Pk) value of 0.825