17 Biological Oscillations of Vascular Origin and Their Meaning …
279
during the late phases of the disease. The patterns of the oscillation frequencies are
the same in both experimental models and humans in clinical settings.
17.4 Conclusions
In conclusion, the regulation of tissue perfusion takes place in the microcirculation,
where the delivery of blood is controlled at the level of arterioles by “an opening and
closing mechanism” that causes intermittent capillary blood flow which is effective in
inducing an efficient delivery of nutrients to the tissue and washout of waste products.
This regulation participates to the overall vascular tone which is subjected to complex
and different control mechanisms, such as those exerted by endothelium-derived
factors, sympathetic nervous system discharge and hormones.
References
1. C. Aalkjær, H. Nilsson, Vasomotion: cellular background for the oscillator and for the synchronization of smooth muscle cells. Br. J. Pharmacol. 144, 605–616 (2005). https://doi.org/10.
1038/sj.bjp.0706084
2. S. Bertuglia, A. Colantuoni, G. Coppini, M. Intaglietta, Hypoxia- or hyperoxia-induced changes
in arteriolar vasomotion in skeletal muscle microcirculation. Am. J. Physiol. 260, H362–H372
(1991)
3. S. Bertuglia, P. Leger, A. Colantuoni, G. Coppini, P. Bendayan, H. Boccalon, Different flow
motion patterns in healthy controls and patients with Raynaud’s phenomenon. Technol. Health
Care 7, 113–123 (1999)
4. E. Bouskela, W. Grampp, Spontaneous vasomotion in hamster cheek pouch arterioles in varying
experimental conditions. Am. J. Physiol. 262, H478–H485 (1992). https://doi.org/10.1152/ajp
heart.1992.262.2.H478
5. R. Chambers, B.W. Zweifach, Topography and function of the mesentery capillary circulation.
Am. J. Anat. 75, 173–206 (1944)
6. E.R. Clark, E.L. Clark, Observation on living preformed blood vessels as seen in a chamber in
the rabbit’s ear. Am. J. Anat. 19, 441–447 (1932)
7. A. Colantuoni, S. Bertuglia, M. Intaglietta, Quantitation of rhythmic diameter changes in
arterial microcirculation. Am. J. Physiol. 246, H508–H517 (1984)
8. A. Colantuoni, S. Bertuglia, M. Intaglietta, Effects of anesthesia on the spontaneous activity
of the microvasculature. Int. J. Microcirc. Clin. Exp. 3, 13–27 (1984)
9. A. Colantuoni, S. Bertuglia, M. Intaglietta, The effects of alpha- or beta-adrenergic receptor
agonists and antagonists and calcium entry blockers on the spontaneous vasomotion. Microvasc.
Res. 28, 143–158 (1984)
10. A. Colantuoni, S. Bertuglia, M. Intaglietta, Variations of rhythmic diameter changes at the
arterial microvascular bifurcations. Pflügers Arch. 403, 289–295 (1985)
11. A. Colantuoni, S. Bertuglia, M. Intaglietta, Microvascular vasomotion: origin of laser Doppler
flux motion. Int. J. Microcir. Clin. Exp. 14, 151–158 (1994). https://doi.org/10.1159/000178823
12. B. Duling, The hamster cheek pouch as a model in microcirculation research. Eur. Respir. J.
Suppl. 12, 595s–600s (1973)
13. J.E. Faber, P.D. Harris, D.L. Wiegman, Anesthetic depression of microcirculation, central
hemodynamics, and respiration in decerebrate rats. Am. J. Physiol. 243, H837–H843 (1982).
https://doi.org/10.1152/ajpheart.1982.243.6.H837
279
during the late phases of the disease. The patterns of the oscillation frequencies are
the same in both experimental models and humans in clinical settings.
17.4 Conclusions
In conclusion, the regulation of tissue perfusion takes place in the microcirculation,
where the delivery of blood is controlled at the level of arterioles by “an opening and
closing mechanism” that causes intermittent capillary blood flow which is effective in
inducing an efficient delivery of nutrients to the tissue and washout of waste products.
This regulation participates to the overall vascular tone which is subjected to complex
and different control mechanisms, such as those exerted by endothelium-derived
factors, sympathetic nervous system discharge and hormones.
References
1. C. Aalkjær, H. Nilsson, Vasomotion: cellular background for the oscillator and for the synchronization of smooth muscle cells. Br. J. Pharmacol. 144, 605–616 (2005). https://doi.org/10.
1038/sj.bjp.0706084
2. S. Bertuglia, A. Colantuoni, G. Coppini, M. Intaglietta, Hypoxia- or hyperoxia-induced changes
in arteriolar vasomotion in skeletal muscle microcirculation. Am. J. Physiol. 260, H362–H372
(1991)
3. S. Bertuglia, P. Leger, A. Colantuoni, G. Coppini, P. Bendayan, H. Boccalon, Different flow
motion patterns in healthy controls and patients with Raynaud’s phenomenon. Technol. Health
Care 7, 113–123 (1999)
4. E. Bouskela, W. Grampp, Spontaneous vasomotion in hamster cheek pouch arterioles in varying
experimental conditions. Am. J. Physiol. 262, H478–H485 (1992). https://doi.org/10.1152/ajp
heart.1992.262.2.H478
5. R. Chambers, B.W. Zweifach, Topography and function of the mesentery capillary circulation.
Am. J. Anat. 75, 173–206 (1944)
6. E.R. Clark, E.L. Clark, Observation on living preformed blood vessels as seen in a chamber in
the rabbit’s ear. Am. J. Anat. 19, 441–447 (1932)
7. A. Colantuoni, S. Bertuglia, M. Intaglietta, Quantitation of rhythmic diameter changes in
arterial microcirculation. Am. J. Physiol. 246, H508–H517 (1984)
8. A. Colantuoni, S. Bertuglia, M. Intaglietta, Effects of anesthesia on the spontaneous activity
of the microvasculature. Int. J. Microcirc. Clin. Exp. 3, 13–27 (1984)
9. A. Colantuoni, S. Bertuglia, M. Intaglietta, The effects of alpha- or beta-adrenergic receptor
agonists and antagonists and calcium entry blockers on the spontaneous vasomotion. Microvasc.
Res. 28, 143–158 (1984)
10. A. Colantuoni, S. Bertuglia, M. Intaglietta, Variations of rhythmic diameter changes at the
arterial microvascular bifurcations. Pflügers Arch. 403, 289–295 (1985)
11. A. Colantuoni, S. Bertuglia, M. Intaglietta, Microvascular vasomotion: origin of laser Doppler
flux motion. Int. J. Microcir. Clin. Exp. 14, 151–158 (1994). https://doi.org/10.1159/000178823
12. B. Duling, The hamster cheek pouch as a model in microcirculation research. Eur. Respir. J.
Suppl. 12, 595s–600s (1973)
13. J.E. Faber, P.D. Harris, D.L. Wiegman, Anesthetic depression of microcirculation, central
hemodynamics, and respiration in decerebrate rats. Am. J. Physiol. 243, H837–H843 (1982).
https://doi.org/10.1152/ajpheart.1982.243.6.H837