Nanomaterials for Medical Imaging …
397
221. Afzalipour R, Khoei S, Khoee S, Shirvalilou S, Jamali Raoufi N, Motevalian M, Karimi MR
(2019) Dual-targeting temozolomide loaded in folate-conjugated magnetic triblock copolymer
nanoparticles to improve the therapeutic efficiency of rat brain gliomas. ACS Biomater Sci
Eng 5(11):6000–6011. https://doi.org/10.1021/acsbiomaterials.9b00856
222. Du C, Liu X, Hu H, Li H, Yu L, Geng D, Chen Y, Zhang J (2020) Dual-targeting and excretable
ultrasmall SPIONs for T1-weighted positive MR imaging of intracranial glioblastoma cells by
targeting the lipoprotein receptor-related protein. J Mater Chem B 8(11):2296–2306. https://
doi.org/10.1039/c9tb02391g
223. Ashwinkumar N, Maya S, Jayakumar R (2014) Redox-responsive cystamine conjugated
chitin–hyaluronic acid composite nanogels. RSC Adv 4(91):49547–49555. https://doi.org/
10.1039/c4ra06578f
224. Ma D, Shi M, Li X, Zhang J, Fan Y, Sun K, Jiang T, Peng C, Shi X (2020) Redox-sensitive
clustered ultrasmall iron oxide nanoparticles for switchable T2/T1-weighted magnetic resonance imaging applications. Bioconjug Chem 31(2):352–359. https://doi.org/10.1021/acs.bio
conjchem.9b00659
225. Lin R, Huang J, Wang L, Li Y, Lipowska M, Wu H, Yang J, Mao H (2018) Bevacizumab and
near infrared probe conjugated iron oxide nanoparticles for vascular endothelial growth factor
targeted MR and optical imaging. Biomater Sci 6(6):1517–1525. https://doi.org/10.1039/c8b
m00225h
226. Mattheolabakis G, Milane L, Singh A, Amiji MM (2015) Hyaluronic acid targeting of CD44
for cancer therapy: from receptor biology to nanomedicine. J Drug Target 23(7–8):605–618.
https://doi.org/10.3109/1061186X.2015.1052072
227. Senbanjo LT, Chellaiah MA (2017) CD44: a multifunctional cell surface adhesion receptor
is a regulator of progression and metastasis of cancer cells. Front Cell Dev Biol 5:18. https://
doi.org/10.3389/fcell.2017.00018
228. Zheng S, Han J, Jin Z, Kim CS, Park S, Kim KP, Park JO, Choi E (2018) Dual tumor-targeted
multifunctional magnetic hyaluronic acid micelles for enhanced MR imaging and combined
photothermal-chemotherapy. Coll Surf B Biointerfaces 164:424–435. https://doi.org/10.1016/
j.colsurfb.2018.02.005
229. Murukesh N, Dive C, Jayson GC (2010) Biomarkers of angiogenesis and their role in the
development of VEGF inhibitors. Br J Cancer 102(1):8–18. https://doi.org/10.1038/sj.bjc.
6605483
230. Ferrara N, Hillan KJ, Novotny W (2005) Bevacizumab (Avastin), a humanized anti-VEGF
monoclonal antibody for cancer therapy. Biochem Biophys Res Commun 333(2):328–335.
https://doi.org/10.1016/j.bbrc.2005.05.132
231. Zou Q, Zhang CJ, Yan YZ, Min ZJ, Li CS (2019) MUC-1 aptamer targeted superparamagnetic
iron oxide nanoparticles for magnetic resonance imaging of pancreatic cancer in vivo and
in vitro experiment. J Cell Biochem 120(11):18650–18658. https://doi.org/10.1002/jcb.28950
232. Gale EM, Wey HY, Ramsay I, Yen YF, Sosnovik DE, Caravan P (2018) A manganese-based
alternative to gadolinium: contrast-enhanced MR angiography, excretion, pharmacokinetics,
and metabolism. Radiology 286(3):865–872. https://doi.org/10.1148/radiol.2017170977
233. Pan D, Schmieder AH, Wickline SA, Lanza GM (2011) Manganese-based MRI contrast
agents: past, present and future. Tetrahedron 67(44):8431–8444. https://doi.org/10.1016/j.tet.
2011.07.076
234. McDonagh BH, Singh G, Hak S, Bandyopadhyay S, Augestad IL, Peddis D, Sandvig I,
Sandvig A, Glomm WR (2016) L-DOPA-coated manganese oxide nanoparticles as dual MRI
contrast agents and drug-delivery vehicles. Small 12(3):301–306. https://doi.org/10.1002/
smll.201502545
235. Wang P, Yang J, Zhou B, Hu Y, Xing L, Xu F, Shen M, Zhang G, Shi X (2017) Antifouling
manganese oxide nanoparticles: synthesis, characterization, and applications for enhanced
MR imaging of tumors. ACS Appl Mater Interfaces 9(1):47–53. https://doi.org/10.1021/acs
ami.6b13844
236. Venter A, Szulc DA, Loai S, Ganesh T, Haedicke IE, Cheng HM (2018) A manganese
porphyrin-based T1 contrast agent for cellular MR imaging of human embryonic stem cells.
Sci Rep 8(1):12129. https://doi.org/10.1038/s41598-018-30661-w
397
221. Afzalipour R, Khoei S, Khoee S, Shirvalilou S, Jamali Raoufi N, Motevalian M, Karimi MR
(2019) Dual-targeting temozolomide loaded in folate-conjugated magnetic triblock copolymer
nanoparticles to improve the therapeutic efficiency of rat brain gliomas. ACS Biomater Sci
Eng 5(11):6000–6011. https://doi.org/10.1021/acsbiomaterials.9b00856
222. Du C, Liu X, Hu H, Li H, Yu L, Geng D, Chen Y, Zhang J (2020) Dual-targeting and excretable
ultrasmall SPIONs for T1-weighted positive MR imaging of intracranial glioblastoma cells by
targeting the lipoprotein receptor-related protein. J Mater Chem B 8(11):2296–2306. https://
doi.org/10.1039/c9tb02391g
223. Ashwinkumar N, Maya S, Jayakumar R (2014) Redox-responsive cystamine conjugated
chitin–hyaluronic acid composite nanogels. RSC Adv 4(91):49547–49555. https://doi.org/
10.1039/c4ra06578f
224. Ma D, Shi M, Li X, Zhang J, Fan Y, Sun K, Jiang T, Peng C, Shi X (2020) Redox-sensitive
clustered ultrasmall iron oxide nanoparticles for switchable T2/T1-weighted magnetic resonance imaging applications. Bioconjug Chem 31(2):352–359. https://doi.org/10.1021/acs.bio
conjchem.9b00659
225. Lin R, Huang J, Wang L, Li Y, Lipowska M, Wu H, Yang J, Mao H (2018) Bevacizumab and
near infrared probe conjugated iron oxide nanoparticles for vascular endothelial growth factor
targeted MR and optical imaging. Biomater Sci 6(6):1517–1525. https://doi.org/10.1039/c8b
m00225h
226. Mattheolabakis G, Milane L, Singh A, Amiji MM (2015) Hyaluronic acid targeting of CD44
for cancer therapy: from receptor biology to nanomedicine. J Drug Target 23(7–8):605–618.
https://doi.org/10.3109/1061186X.2015.1052072
227. Senbanjo LT, Chellaiah MA (2017) CD44: a multifunctional cell surface adhesion receptor
is a regulator of progression and metastasis of cancer cells. Front Cell Dev Biol 5:18. https://
doi.org/10.3389/fcell.2017.00018
228. Zheng S, Han J, Jin Z, Kim CS, Park S, Kim KP, Park JO, Choi E (2018) Dual tumor-targeted
multifunctional magnetic hyaluronic acid micelles for enhanced MR imaging and combined
photothermal-chemotherapy. Coll Surf B Biointerfaces 164:424–435. https://doi.org/10.1016/
j.colsurfb.2018.02.005
229. Murukesh N, Dive C, Jayson GC (2010) Biomarkers of angiogenesis and their role in the
development of VEGF inhibitors. Br J Cancer 102(1):8–18. https://doi.org/10.1038/sj.bjc.
6605483
230. Ferrara N, Hillan KJ, Novotny W (2005) Bevacizumab (Avastin), a humanized anti-VEGF
monoclonal antibody for cancer therapy. Biochem Biophys Res Commun 333(2):328–335.
https://doi.org/10.1016/j.bbrc.2005.05.132
231. Zou Q, Zhang CJ, Yan YZ, Min ZJ, Li CS (2019) MUC-1 aptamer targeted superparamagnetic
iron oxide nanoparticles for magnetic resonance imaging of pancreatic cancer in vivo and
in vitro experiment. J Cell Biochem 120(11):18650–18658. https://doi.org/10.1002/jcb.28950
232. Gale EM, Wey HY, Ramsay I, Yen YF, Sosnovik DE, Caravan P (2018) A manganese-based
alternative to gadolinium: contrast-enhanced MR angiography, excretion, pharmacokinetics,
and metabolism. Radiology 286(3):865–872. https://doi.org/10.1148/radiol.2017170977
233. Pan D, Schmieder AH, Wickline SA, Lanza GM (2011) Manganese-based MRI contrast
agents: past, present and future. Tetrahedron 67(44):8431–8444. https://doi.org/10.1016/j.tet.
2011.07.076
234. McDonagh BH, Singh G, Hak S, Bandyopadhyay S, Augestad IL, Peddis D, Sandvig I,
Sandvig A, Glomm WR (2016) L-DOPA-coated manganese oxide nanoparticles as dual MRI
contrast agents and drug-delivery vehicles. Small 12(3):301–306. https://doi.org/10.1002/
smll.201502545
235. Wang P, Yang J, Zhou B, Hu Y, Xing L, Xu F, Shen M, Zhang G, Shi X (2017) Antifouling
manganese oxide nanoparticles: synthesis, characterization, and applications for enhanced
MR imaging of tumors. ACS Appl Mater Interfaces 9(1):47–53. https://doi.org/10.1021/acs
ami.6b13844
236. Venter A, Szulc DA, Loai S, Ganesh T, Haedicke IE, Cheng HM (2018) A manganese
porphyrin-based T1 contrast agent for cellular MR imaging of human embryonic stem cells.
Sci Rep 8(1):12129. https://doi.org/10.1038/s41598-018-30661-w