360
N. Ashwin Kumar et al.
Fig. 15 PEGylated Gadolinium (a) and Erbium (b) doped Yb based oxide NPs for dual-modal
imaging (X-ray CT and NIR fluorescence imaging). The percentage of injected dose per gram was
determined using ICP analysis, which clearly showed that accumulation in liver and spleen are ~42
and ~30 after 24 h of post-injection [134, 135]
Fig. 16 Multispectral or dual-energy CT imaging using Yb based oxide NPs: Yb nano colloids are
used as a contrast to determine plaque formation using multi-spectral CT imaging. Adapted from
reference [137]
different forms of Yb were synthesized mainly as CT contrast and up-conversion
hybrid nanomaterials.
Despite a long history of nanoparticles-based contrast agent development for Xray imaging applications, there is still potential to improve in both pre-clinical and
clinical practice. Improving properties such as prolonged circulation and the ability
to target the particles would accelerate the innovation in CT imaging. This eventually can lead to detecting various disease diagnoses at an early stage. Since X-ray
N. Ashwin Kumar et al.
Fig. 15 PEGylated Gadolinium (a) and Erbium (b) doped Yb based oxide NPs for dual-modal
imaging (X-ray CT and NIR fluorescence imaging). The percentage of injected dose per gram was
determined using ICP analysis, which clearly showed that accumulation in liver and spleen are ~42
and ~30 after 24 h of post-injection [134, 135]
Fig. 16 Multispectral or dual-energy CT imaging using Yb based oxide NPs: Yb nano colloids are
used as a contrast to determine plaque formation using multi-spectral CT imaging. Adapted from
reference [137]
different forms of Yb were synthesized mainly as CT contrast and up-conversion
hybrid nanomaterials.
Despite a long history of nanoparticles-based contrast agent development for Xray imaging applications, there is still potential to improve in both pre-clinical and
clinical practice. Improving properties such as prolonged circulation and the ability
to target the particles would accelerate the innovation in CT imaging. This eventually can lead to detecting various disease diagnoses at an early stage. Since X-ray