Nanomaterials: Versatile Drug Carriers for Nanomedicine
259
Table 1
(continued)
Drug/active ingredients System components
Aim
Major applications
Route of
administration
Rivastigmine
Polysorbate-80
To prolong the drug
release
Improved cognitive
functions and memory
Oral delivery
Polymeric
micelles
Doxorubicin
Styrene-Maleic acid
To improve the
solubility of the
drug
Decreased cardiac and bone
marrow toxicity
In vitro
NK012
PEG-P(Glu)
To reduce
side-effects
Reduced gastrointestinal
toxicity; reduced therapy
In vitro
Cisplatin
PEG-P(Glu)
To reduce
side-effects
Reduced nephrotoxicity,
neurotoxicity; sustained
release; readily
accumulation with cancer
cells
In vitro
Docetaxel
PLA-PEG
To site specific
Targeted to prostate-specific
membrane antigen;
Prolonged tumor growth
suppression
In vitro
Daunomycin
SDS-Triton X-100
To hydrophobic
contribution
Hydrophobic contribution
to the free energy of DNA
intercalation reaction
In vitro
Paclitaxel
PGG
To improve the
therapeutic index
Effectively inhibiting tumor
growth
Oral delivery
Polymer
conjugates
Doxorubicin
PEG
To improve the
solubility of the
drug
Decreased toxicity
In vitro
(continued)