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Table 1
Examples of nanotechnology and nano-carrier-based drug delivery systems, compositions, aims, applications and route of administration for disease
treatment
Drug/active ingredients System components
Aim
Major applications
Route of
administration
Polymeric
Nanoparticle
Amphotericin B
PLGA, PEG
To improve oral
bioavailability
Increased oral
bioavailability; decreased
adverse effects
(Nephrotoxicity)
Oral delivery
Cisplatin
PLG-g-mPEG5K
To increase
bioavailability
Increased oral
bioavailability; decreased
adverse effects
In vitro
and
in vivo
Exenatide
PLGA-PEG-PLGA
To long-acting
Extended-release of drug
In vitro
Ellipticine
PHAs-PHBVs
To improve
bioavailability
Increased biocompatibility
and bioavailability;
increased cytotoxicity
In vitro
Tamoxifen-Quercetin
PLGA
To increase
bioavailability
Threefold increased oral
bioavailability, reduced the
therapy; higher cellular
uptake
Oral delivery
Topotecan-Tamoxifen
PLGA
To synergistic effect Achieved synergism;
reduced side effects;
enhance permeation of cells;
increased bioavailability
In vitro
and
in vivo
Naringenin
PVA-Eudrgit(R) E 100
To improve oral
bioavailability
Highly biocompatibility and
high therapeutic efficacy
Oral delivery
Curcumin
NIPAAM/VP/PEG-A
To improve the
solubility of the
drug
Increased oral
bioavailability
Oral delivery
(continued)