Classical- and Heterodyne-Detected Vibrational Sum …
111
Fig. 12 a air-water-TBA interface ([TBA] = 0.1 mol L −1 ); and b air-water-TMAO interface
([TMAO] = 3.0 mol L −1 ). The spectrum of the neat air-water interface (black curve) is also shown
in each panel. c, d depict the schematic of the air-water interface in presence of TBA and TMAO,
respectively. Adapted with permission from [31]. Copyright 2016 American Chemical Society
5.6 Osmolyte (TMAO) at Phospholipid Monolayer-Water
Interface
TMAO not only has beneficial effect as an osmolyte; recent studies have suggested
adverse effect of TMAO on human health, specifically it increases the risk of cardiovascular diseases (CVD), presumably by promoting fat deposition at the inner wall
of artery [66, 67]. In human, TMAO is produced from its precursor trimethylamine
(TMA), which is derived from the bacterial degradation of choline containing food
(e.g., egg, red meat). This increases the TMAO level in blood. Although, how does
TMAO promote the deposition of fat in the inner wall of artery is largely unknown, it
is observed that presence of TMAO creates electrical disturbance at the endothelial
membrane forming lipid monolayer-water interface.
111
Fig. 12 a air-water-TBA interface ([TBA] = 0.1 mol L −1 ); and b air-water-TMAO interface
([TMAO] = 3.0 mol L −1 ). The spectrum of the neat air-water interface (black curve) is also shown
in each panel. c, d depict the schematic of the air-water interface in presence of TBA and TMAO,
respectively. Adapted with permission from [31]. Copyright 2016 American Chemical Society
5.6 Osmolyte (TMAO) at Phospholipid Monolayer-Water
Interface
TMAO not only has beneficial effect as an osmolyte; recent studies have suggested
adverse effect of TMAO on human health, specifically it increases the risk of cardiovascular diseases (CVD), presumably by promoting fat deposition at the inner wall
of artery [66, 67]. In human, TMAO is produced from its precursor trimethylamine
(TMA), which is derived from the bacterial degradation of choline containing food
(e.g., egg, red meat). This increases the TMAO level in blood. Although, how does
TMAO promote the deposition of fat in the inner wall of artery is largely unknown, it
is observed that presence of TMAO creates electrical disturbance at the endothelial
membrane forming lipid monolayer-water interface.