296
A. V. Ravi et al.
8 Conclusions and Future Perspectives
Exhaustive farming has stimulated the spreading of numerous bacterial diseases,
which has propelled the over usage of antimicrobial drugs. The increasing proportions of multi-drug resistant bacteria that persist in residues and farm environments
provide a threat to aquaculture. Several alternative approaches to antibiotics have
been developed and some of them have been successfully implemented to control
bacterial infections in aquaculture facilities.
Overall, this review presented a brief idea on the problems and challenges associated with antibiotic resistance and significance of quorum sensing inhibitors as alternative strategies to conquer the antibiotic resistance and thwart the emerging bacterial infections with less selective pressure among pathogenic bacterial organisms.
Hence, usage of QSIs is promising in the development of novel antipathogenic drugs
to control vibriosis caused by antibiotic resistant vibrios in aquaculture. Besides,
novel therapeutic strategies could be intended based on information garnered from
studies of quourum sensing and quorum sensing inhibitors. This research findings
and existing positive reports suggest that, quorum sensing could be a thrust area of
research in order to combat emerging infectious agents in aquaculture with enormous
other practical applications.
Acknowledgements The author S. Santhakumari gratefully acknowledges the Department of
Biotechnology, Government of India (Grant No. BT/PR4815/AAQ/3/587/2012), for the financial support in the form of DBT- JRF & SRF. The author also thank the Department of
Science and Technology, SCIENCE & ENGINEERING RESEARCH BOARD (SERB) (Grant
No. PDF/2018/001518), for the financial support in the form of National Post-Doctoral
fellowship (N-PDF). Also, the authors gratefully acknowledge the Department of Biotechnology, Governmentof India, for providing Bioinformatics Infrastructure Facility[Grant No.
BT/BI/25/012/2012(BIF)] at Alagappa University. The authors also acknowledge DST-FIST
[Grant No. SR/FST/LSI-639/2015(C)],UGC-SAP[GrantNo.F.5-1/2018/DRS-II(SAPII)], and DSTPURSE [Grant No. SR/PURSE Phase 2/38(G)]for providing instrumentation facilities.
References
Annapoorani A, Jabbar AKKA, Musthafa SKS, Pandian SK, Ravi AV (2012a) Inhibition of quorum
sensing mediated virulence factors production in urinary pathogen Serratia marcescens PS1 by
marine sponges. Indian J Microbiol 52:160–166
Annapoorani A, Umamageswaran V, Parameswari R, Pandian SK, Ravi AV (2012b) Computational
discovery of putative quorum sensing inhibitors against LasR and RhlR receptor proteins of
Pseudomonas aeruginosa. J Comput Aided Mol Des 26:1067–1077
Austin B, Zhang XH (2006) Vibrio harveyi: a significant pathogen of marine vertebrates and
invertebrates. Lett Appl Microbiol 43:119–124
Brackman G, Celen S, Hillaert U, Calenbergh SV, Cos P, Maes L, Nelis HJ, Coenye T (2011)
Structure-activity relationship of cinnamaldehyde analogs as inhibitors of AI-2 based quorum
sensing and their effect on virulence of Vibrio spp. PLoS ONE 6:1–10
A. V. Ravi et al.
8 Conclusions and Future Perspectives
Exhaustive farming has stimulated the spreading of numerous bacterial diseases,
which has propelled the over usage of antimicrobial drugs. The increasing proportions of multi-drug resistant bacteria that persist in residues and farm environments
provide a threat to aquaculture. Several alternative approaches to antibiotics have
been developed and some of them have been successfully implemented to control
bacterial infections in aquaculture facilities.
Overall, this review presented a brief idea on the problems and challenges associated with antibiotic resistance and significance of quorum sensing inhibitors as alternative strategies to conquer the antibiotic resistance and thwart the emerging bacterial infections with less selective pressure among pathogenic bacterial organisms.
Hence, usage of QSIs is promising in the development of novel antipathogenic drugs
to control vibriosis caused by antibiotic resistant vibrios in aquaculture. Besides,
novel therapeutic strategies could be intended based on information garnered from
studies of quourum sensing and quorum sensing inhibitors. This research findings
and existing positive reports suggest that, quorum sensing could be a thrust area of
research in order to combat emerging infectious agents in aquaculture with enormous
other practical applications.
Acknowledgements The author S. Santhakumari gratefully acknowledges the Department of
Biotechnology, Government of India (Grant No. BT/PR4815/AAQ/3/587/2012), for the financial support in the form of DBT- JRF & SRF. The author also thank the Department of
Science and Technology, SCIENCE & ENGINEERING RESEARCH BOARD (SERB) (Grant
No. PDF/2018/001518), for the financial support in the form of National Post-Doctoral
fellowship (N-PDF). Also, the authors gratefully acknowledge the Department of Biotechnology, Governmentof India, for providing Bioinformatics Infrastructure Facility[Grant No.
BT/BI/25/012/2012(BIF)] at Alagappa University. The authors also acknowledge DST-FIST
[Grant No. SR/FST/LSI-639/2015(C)],UGC-SAP[GrantNo.F.5-1/2018/DRS-II(SAPII)], and DSTPURSE [Grant No. SR/PURSE Phase 2/38(G)]for providing instrumentation facilities.
References
Annapoorani A, Jabbar AKKA, Musthafa SKS, Pandian SK, Ravi AV (2012a) Inhibition of quorum
sensing mediated virulence factors production in urinary pathogen Serratia marcescens PS1 by
marine sponges. Indian J Microbiol 52:160–166
Annapoorani A, Umamageswaran V, Parameswari R, Pandian SK, Ravi AV (2012b) Computational
discovery of putative quorum sensing inhibitors against LasR and RhlR receptor proteins of
Pseudomonas aeruginosa. J Comput Aided Mol Des 26:1067–1077
Austin B, Zhang XH (2006) Vibrio harveyi: a significant pathogen of marine vertebrates and
invertebrates. Lett Appl Microbiol 43:119–124
Brackman G, Celen S, Hillaert U, Calenbergh SV, Cos P, Maes L, Nelis HJ, Coenye T (2011)
Structure-activity relationship of cinnamaldehyde analogs as inhibitors of AI-2 based quorum
sensing and their effect on virulence of Vibrio spp. PLoS ONE 6:1–10