Takahashi K, Yamanaka S (2006) Induction of pluripotent stem cells from mouse embryonic and
adult fibroblast cultures by defined factors. Cell 126:663–676
Takahashi K, Tanabe K, Ohnuki M, Narita M, Ichisaka T, Tomoda K, Yamanaka S (2007)
Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell
131:861–872
Tamm C, Duckworth J, Hermanson O, Ceccatelli S (2006) High susceptibility of neural stem cells
to methylmercury toxicity: effects on cell survival and neuronal differentiation. J Neurochem
97:69–78
Tanentzapf G, Devenport D, Godt D, Brown NH (2007) Integrin-dependent anchoring of a stemcell niche. Nat Cell Biol 9:1413–1418
Theunissen TW, Powell BE, Wang H, Mitalipova M, Faddah DA, Reddy J, Fan ZP, Maetzel D,
Ganz K, Shi L, Lungjangwa T, Imsoonthornruksa S, Stelzer Y, Rangarajan S, D’Alessio A,
Zhang J, Gao Q, Dawlaty MM, Young RA, Gray NS, Jaenisch R (2014) Systematic identification of culture conditions for induction and maintenance of naive human pluripotency. Cell
Stem Cell 15:524–526
Thomson JA, Itskovitz-Eldor J, Shapiro SS, Waknitz MA, Swiergiel JJ, Marshall VS, Jones JM
(1998) Embryonic stem cell lines derived from human blastocysts. Science 282:1145–1147
Tumbar T, Guasch G, Greco V, Blanpain C, Lowry WE, Rendl M, Fuchs E (2004) Defining the
epithelial stem cell niche in skin. Science 303:359–363
Walker MR, Stappenbeck TS (2008) Deciphering the ‘black box’ of the intestinal stem cell niche:
taking direction from other systems. Curr Opin Gastroenterol 24:115–120
Wang YZ, Plane JM, Jiang P, Zhou CJ, Deng W (2011) Concise review: quiescent and active states
of endogenous adult neural stem cells: identification and characterization. Stem Cells
29:907–912
Wang P-Y, Thissen H, Kingshott P (2016) Modulation of human multipotent and pluripotent stem
cells using surface nanotopographies and surface-immobilised bioactive signals: a review. Acta
Biomater 45:31–59
Whitlow S, Burgin H, Clemann N (2007) The embryonic stem cell test for the early selection of
pharmaceutical compounds. ALTEX 24:3–7
Wilmut I, Schnieke AE, McWhir J, Kind AJ, Campbell KH (1997) Viable offspring derived from
fetal and adult mammalian cells. Nature 385:810–813
Wobus AM, Loser P (2011) Present state and future perspectives of using pluripotent stem cells in
toxicology research. Arch Toxicol 85:79–117
Wu S, Powers S, Zhu W, Hannun YA (2015) Substantial contribution of extrinsic risk factors to
cancer development. Nature 529:43–47
Xie T, Li L (2007) Stem cells and their niche: an inseparable relationship. Development
134:2001–2006
Yao X, Yin N, Faiola F (2016) Stem cell toxicology: a powerful tool to assess pollution effects on
human health. Natl Sci Rev 3:430–450
Yu J, Vodyanik MA, Smuga-Otto K, Antosiewicz-Bourget J, Frane JL, Tian S, Nie J, Jonsdottir
GA, Ruotti V, Stewart R, Slukvin II, Thomson JA (2007) Induced pluripotent stem cell lines
derived from human somatic cells. Science 318:1917–1920
Zhang J, Niu C, Ye L, Huang H, He X, Tong WG, Ross J, Haug J, Johnson T, Feng JQ, Harris S,
Wiedemann LM, Mishina Y, Li L (2003) Identification of the haematopoietic stem cell niche
and control of the niche size. Nature 425:836–841
Zhao AH (2015) Stem cells, environment, and cancer risk. Stem Cell Invest 2:24
Zur Nieden NI, Ruf LJ, Kempka G, Hildebrand H, Ahr HJ (2001) Molecular markers in embryonic
stem cells. Toxicol In Vitro 15:455–461
Zur Nieden NI, Kempka G, Ahr HJ (2004) Molecular multiple endpoint embryonic stem cell test--a
possible approach to test for the teratogenic potential of compounds. Toxicol Appl Pharmacol
194:257–269
12 Environmental Interaction and Impact on the Life Span of Stem Cells
265
adult fibroblast cultures by defined factors. Cell 126:663–676
Takahashi K, Tanabe K, Ohnuki M, Narita M, Ichisaka T, Tomoda K, Yamanaka S (2007)
Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell
131:861–872
Tamm C, Duckworth J, Hermanson O, Ceccatelli S (2006) High susceptibility of neural stem cells
to methylmercury toxicity: effects on cell survival and neuronal differentiation. J Neurochem
97:69–78
Tanentzapf G, Devenport D, Godt D, Brown NH (2007) Integrin-dependent anchoring of a stemcell niche. Nat Cell Biol 9:1413–1418
Theunissen TW, Powell BE, Wang H, Mitalipova M, Faddah DA, Reddy J, Fan ZP, Maetzel D,
Ganz K, Shi L, Lungjangwa T, Imsoonthornruksa S, Stelzer Y, Rangarajan S, D’Alessio A,
Zhang J, Gao Q, Dawlaty MM, Young RA, Gray NS, Jaenisch R (2014) Systematic identification of culture conditions for induction and maintenance of naive human pluripotency. Cell
Stem Cell 15:524–526
Thomson JA, Itskovitz-Eldor J, Shapiro SS, Waknitz MA, Swiergiel JJ, Marshall VS, Jones JM
(1998) Embryonic stem cell lines derived from human blastocysts. Science 282:1145–1147
Tumbar T, Guasch G, Greco V, Blanpain C, Lowry WE, Rendl M, Fuchs E (2004) Defining the
epithelial stem cell niche in skin. Science 303:359–363
Walker MR, Stappenbeck TS (2008) Deciphering the ‘black box’ of the intestinal stem cell niche:
taking direction from other systems. Curr Opin Gastroenterol 24:115–120
Wang YZ, Plane JM, Jiang P, Zhou CJ, Deng W (2011) Concise review: quiescent and active states
of endogenous adult neural stem cells: identification and characterization. Stem Cells
29:907–912
Wang P-Y, Thissen H, Kingshott P (2016) Modulation of human multipotent and pluripotent stem
cells using surface nanotopographies and surface-immobilised bioactive signals: a review. Acta
Biomater 45:31–59
Whitlow S, Burgin H, Clemann N (2007) The embryonic stem cell test for the early selection of
pharmaceutical compounds. ALTEX 24:3–7
Wilmut I, Schnieke AE, McWhir J, Kind AJ, Campbell KH (1997) Viable offspring derived from
fetal and adult mammalian cells. Nature 385:810–813
Wobus AM, Loser P (2011) Present state and future perspectives of using pluripotent stem cells in
toxicology research. Arch Toxicol 85:79–117
Wu S, Powers S, Zhu W, Hannun YA (2015) Substantial contribution of extrinsic risk factors to
cancer development. Nature 529:43–47
Xie T, Li L (2007) Stem cells and their niche: an inseparable relationship. Development
134:2001–2006
Yao X, Yin N, Faiola F (2016) Stem cell toxicology: a powerful tool to assess pollution effects on
human health. Natl Sci Rev 3:430–450
Yu J, Vodyanik MA, Smuga-Otto K, Antosiewicz-Bourget J, Frane JL, Tian S, Nie J, Jonsdottir
GA, Ruotti V, Stewart R, Slukvin II, Thomson JA (2007) Induced pluripotent stem cell lines
derived from human somatic cells. Science 318:1917–1920
Zhang J, Niu C, Ye L, Huang H, He X, Tong WG, Ross J, Haug J, Johnson T, Feng JQ, Harris S,
Wiedemann LM, Mishina Y, Li L (2003) Identification of the haematopoietic stem cell niche
and control of the niche size. Nature 425:836–841
Zhao AH (2015) Stem cells, environment, and cancer risk. Stem Cell Invest 2:24
Zur Nieden NI, Ruf LJ, Kempka G, Hildebrand H, Ahr HJ (2001) Molecular markers in embryonic
stem cells. Toxicol In Vitro 15:455–461
Zur Nieden NI, Kempka G, Ahr HJ (2004) Molecular multiple endpoint embryonic stem cell test--a
possible approach to test for the teratogenic potential of compounds. Toxicol Appl Pharmacol
194:257–269
12 Environmental Interaction and Impact on the Life Span of Stem Cells
265