Buesen R, Genschow E, Slawik B, Visan A, Spielmann H, Luch A, Seiler A (2009) Embryonic
stem cell test remastered: comparison between the validated EST and the new molecular FACSEST for assessing developmental toxicity in vitro. Toxicol Sci 108:389–400
Buzanska L, Sypecka J, Nerini-Molteni S, Compagnoni A, Hogberg HT, del Torchio R, DomanskaJanik K, Zimmer J, Coecke S (2009) A human stem cell-based model for identifying adverse
effects of organic and inorganic chemicals on the developing nervous system. Stem Cells
27:2591–2601
Cao T, Lu K, Fu X, Heng BC (2008) Differentiated fibroblastic progenies of human embryonic stem
cells for toxicology screening. Cloning Stem Cells 10:1–10
Chen S, Lewallen M, Xie T (2013) Adhesion in the stem cell niche: biological roles and regulation.
Development 140:255–265
De Cuevas M, Matunis EL (2011) The stem cell niche: lessons from the Drosophila testis.
Development 138:2861–2869
de Jong E, Louisse J, Verwei M, Blaauboer BJ, van de Sandt JJ, Woutersen RA, Rietjens IM,
Piersma AH (2009) Relative developmental toxicity of glycol ether alkoxy acid metabolites in
the embryonic stem cell test as compared with the in vivo potency of their parent compounds.
Toxicol Sci 110:117–124
Di Guglielmo C, Lopez DR, De Lapuente J, Mallafre JM, Suarez MB (2010) Embryotoxicity of
cobalt ferrite and gold nanoparticles: a first in vitro approach. Reprod Toxicol 30:271–276
Ding S, Kingshott P, Thissen H, Pera M, Wang PY (2016) Modulation of human mesenchymal and
pluripotent stem cell behavior using biophysical and biochemical cues: a review. Biotechnol
Bioeng 114:260–280
Ema HS, Suda T (2012) Two anatomically distinct niches regulate stem cell activity. Blood
120:2174–2181
Engstrom W, Darbre P, Eriksson S, Gulliver L, Hultman T, Karamouzis MV, Klaunig JE, Mehta R,
Moorwood K, Sanderson T, Sone H, Vadgama P, Wagemaker G, Ward A, Singh N, Al-Mulla F,
Al-Temaimi R, Amedei A, Colacci AM, Vaccari M, Mondello C, Scovassi AI, Raju J, Hamid
RA, Memeo L, Forte S, Roy R, Woodrick J, Salem HK, Ryan EP, Brown DG, Bisson WH
(2015) The potential for chemical mixtures from the environment to enable the cancer hallmark
of sustained proliferative signalling. Carcinogenesis 36(Suppl 1):S38–S60
Engström W, Darbre P, Eriksson S, Gulliver L, Hultman T, Karamouzis MV, Klaunig JE, Mehta R,
Moorwood K, Sanderson T, Sone H, Vadgama P, Wagemaker G, Ward A, Singh N, Al-Mulla F,
Al-Temaimi R, Amedei A, Colacci AM, Vaccari M, Mondello C, Scovassi AI, Raju J, Hamid
RA, Memeo L, Forte S, Roy R, Woodrick J, Salem HK, Ryan EP, Brown DG, Bisson WH
(2015) The potential for chemical mixtures from the environment to enable the cancer hallmark
of sustained proliferative signalling. Carcinogenesis 36(Suppl 1):S38–S60
Evans MJ, Kaufman MH (1981) Establishment in culture of pluripotential cells from mouse
embryos. Nature 292:154–156
Faiola F, Yin N, Yao X, Jiang G (2015) The rise of stem cell toxicology. Environ Sci Technol
49:5847–5848
Frantz C, Stewart KM, Weaver VM (2010) The extracellular matrix at a glance. J Cell Sci
123:4195–4200
Gabriela GC, Jessica AQ, Alan MS, Guilherme JMR, Marian SP, James FB, Fred HG, Alysson RM
(2007) Identification of small molecules from human embryonic stem cells using metabolomics.
Stem Cells Dev 16:869–882
Genschow E, Spielmann H, Scholz G, Seiler A, Brown N, Piersma A, Brady M, Clemann N,
Huuskonen H, Paillard F, Bremer S, Becker K (2002) The ECVAM international validation
study on in vitro embryotoxicity tests: results of the definitive phase and evaluation of prediction
models. European Centre for the Validation of alternative methods. Altern Lab Anim
30:151–176
Gibb S (2008) Toxicity testing in the 21st century: a vision and a strategy. Reprod Toxicol
25:136–138
262
A. Kumar et al.
stem cell test remastered: comparison between the validated EST and the new molecular FACSEST for assessing developmental toxicity in vitro. Toxicol Sci 108:389–400
Buzanska L, Sypecka J, Nerini-Molteni S, Compagnoni A, Hogberg HT, del Torchio R, DomanskaJanik K, Zimmer J, Coecke S (2009) A human stem cell-based model for identifying adverse
effects of organic and inorganic chemicals on the developing nervous system. Stem Cells
27:2591–2601
Cao T, Lu K, Fu X, Heng BC (2008) Differentiated fibroblastic progenies of human embryonic stem
cells for toxicology screening. Cloning Stem Cells 10:1–10
Chen S, Lewallen M, Xie T (2013) Adhesion in the stem cell niche: biological roles and regulation.
Development 140:255–265
De Cuevas M, Matunis EL (2011) The stem cell niche: lessons from the Drosophila testis.
Development 138:2861–2869
de Jong E, Louisse J, Verwei M, Blaauboer BJ, van de Sandt JJ, Woutersen RA, Rietjens IM,
Piersma AH (2009) Relative developmental toxicity of glycol ether alkoxy acid metabolites in
the embryonic stem cell test as compared with the in vivo potency of their parent compounds.
Toxicol Sci 110:117–124
Di Guglielmo C, Lopez DR, De Lapuente J, Mallafre JM, Suarez MB (2010) Embryotoxicity of
cobalt ferrite and gold nanoparticles: a first in vitro approach. Reprod Toxicol 30:271–276
Ding S, Kingshott P, Thissen H, Pera M, Wang PY (2016) Modulation of human mesenchymal and
pluripotent stem cell behavior using biophysical and biochemical cues: a review. Biotechnol
Bioeng 114:260–280
Ema HS, Suda T (2012) Two anatomically distinct niches regulate stem cell activity. Blood
120:2174–2181
Engstrom W, Darbre P, Eriksson S, Gulliver L, Hultman T, Karamouzis MV, Klaunig JE, Mehta R,
Moorwood K, Sanderson T, Sone H, Vadgama P, Wagemaker G, Ward A, Singh N, Al-Mulla F,
Al-Temaimi R, Amedei A, Colacci AM, Vaccari M, Mondello C, Scovassi AI, Raju J, Hamid
RA, Memeo L, Forte S, Roy R, Woodrick J, Salem HK, Ryan EP, Brown DG, Bisson WH
(2015) The potential for chemical mixtures from the environment to enable the cancer hallmark
of sustained proliferative signalling. Carcinogenesis 36(Suppl 1):S38–S60
Engström W, Darbre P, Eriksson S, Gulliver L, Hultman T, Karamouzis MV, Klaunig JE, Mehta R,
Moorwood K, Sanderson T, Sone H, Vadgama P, Wagemaker G, Ward A, Singh N, Al-Mulla F,
Al-Temaimi R, Amedei A, Colacci AM, Vaccari M, Mondello C, Scovassi AI, Raju J, Hamid
RA, Memeo L, Forte S, Roy R, Woodrick J, Salem HK, Ryan EP, Brown DG, Bisson WH
(2015) The potential for chemical mixtures from the environment to enable the cancer hallmark
of sustained proliferative signalling. Carcinogenesis 36(Suppl 1):S38–S60
Evans MJ, Kaufman MH (1981) Establishment in culture of pluripotential cells from mouse
embryos. Nature 292:154–156
Faiola F, Yin N, Yao X, Jiang G (2015) The rise of stem cell toxicology. Environ Sci Technol
49:5847–5848
Frantz C, Stewart KM, Weaver VM (2010) The extracellular matrix at a glance. J Cell Sci
123:4195–4200
Gabriela GC, Jessica AQ, Alan MS, Guilherme JMR, Marian SP, James FB, Fred HG, Alysson RM
(2007) Identification of small molecules from human embryonic stem cells using metabolomics.
Stem Cells Dev 16:869–882
Genschow E, Spielmann H, Scholz G, Seiler A, Brown N, Piersma A, Brady M, Clemann N,
Huuskonen H, Paillard F, Bremer S, Becker K (2002) The ECVAM international validation
study on in vitro embryotoxicity tests: results of the definitive phase and evaluation of prediction
models. European Centre for the Validation of alternative methods. Altern Lab Anim
30:151–176
Gibb S (2008) Toxicity testing in the 21st century: a vision and a strategy. Reprod Toxicol
25:136–138
262
A. Kumar et al.