Lesage G, Bussey H (2006) Cell wall assembly in Saccharomyces cerevisiae. Microbiol Mol Biol Rev
70:317–343
Levin DE (2011) Regulation of cell wall biogenesis in
Saccharomyces cerevisiae: the cell wall integrity
signaling pathway. Genetics 189:1145–1175
Li H, Korennykh AV, Behrman SL, Walter P (2010)
Mammalian endoplasmic reticulum stress sensor
IRE1 signals by dynamic clustering. Proc Natl
Acad Sci U S A 107:16113–16118
Li W, Okreglak V, Peschek J, Kimmig P, Zubradt M,
Weissman JS, Walter P (2018) Engineering ERstress dependent non-conventional mRNA splicing. elife 7
Li K, Ouyang H, Lu Y, Liang J, Wilson IBH, Jin C (2011)
Repression of N-glycosylation triggers the
unfolded protein response (UPR) and overexpression of cell wall protein and chitin in Aspergillus
fumigatus. Microbiology 157:1968–1979
Lima Pde S, Chung D, Bailao AM, Cramer RA, Soares
CM (2015) Characterization of the Paracoccidioides hypoxia response reveals new insights
into pathogenesis mechanisms of this important
human pathogenic fungus. PLoS Negl Trop Dis 9:
e0004282
Lipatova Z, Segev N (2015) A role for macro-ER-Phagy
in ER quality control. PLoS Genet 11:e1005390
Lo Presti L, Lopez Diaz C, Turra D, Di Pietro A, Hampel
M, Heimel K, Kahmann R (2016) A conserved cochaperone is required for virulence in fungal plant
pathogens. New Phytol 209:1135–1148
Lombrana M, Moralejo FJ, Pinto R, Martin JF (2004)
Modulation of Aspergillus awamori thaumatin
secretion by modification of bipA gene expression.
Appl Environ Microbiol 70:5145–5152
Malavazi I, Goldman GH, Brown NA (2014) The importance of connections between the cell wall integrity
pathway and the unfolded protein response in
filamentous fungi. Brief Funct Genomics
13:456–470
Marschall R, Tudzynski P (2017) The protein disulfide
Isomerase of Botrytis cinerea: an ER protein
involved in protein folding and redox homeostasis
influences NADPH oxidase signaling processes.
Front Microbiol 8:960
Mathioni SM, Belo A, Rizzo CJ, Dean RA, Donofrio NM
(2011) Transcriptome profiling of the rice blast
fungus during invasive plant infection and
in vitro stresses. BMC Genomics 12:49
Merivuori H, Siegler KM, Sands JA, Montenecourt BS
(1985) Regulation of cellulase biosynthesis and
secretion in fungi. Biochem Soc Trans 13:411–414
Miyazaki T, Kohno S (2014) ER stress response mechanisms in the pathogenic yeast Candida glabrata and
their roles in virulence. Virulence 5:365–370
Miyazaki T, Nakayama H, Nagayoshi Y, Kakeya H,
Kohno S (2013) Dissection of Ire1 functions
reveals stress response mechanisms uniquely
evolved in Candida glabrata. PLoS Pathog 9:
e1003160
Mochida K, Oikawa Y, Kimura Y, Kirisako H, Hirano H,
Ohsumi Y, Nakatogawa H (2015) Receptormediated selective autophagy degrades the endoplasmic reticulum and the nucleus. Nature
522:359–362
Monteiro JP, Clemons KV, Mirels LF, Coller JA Jr, Wu
TD, Shankar J, Lopes CR, Stevens DA (2009) Genomic DNA microarray comparison of gene expression patterns in Paracoccidioides brasiliensis
mycelia and yeasts in vitro. Microbiology
155:2795–2808
Montenecourt BS, Nhlapo SD, Trimino-Vazquez H,
Cuskey S, Schamhart DH, Eveleigh DE (1981) Regulatory controls in relation to over-production of
fungal cellulases. Basic Life Sci 18:33–53
Montenegro-Montero A, Goity A, Larrondo LF (2015)
The bZIP transcription factor HAC-1 is involved in
the unfolded protein response and is necessary for
growth on cellulose in Neurospora crassa. PLoS
One 10:e0131415
Mori K, Ma W, Gething MJ, Sambrook J (1993) A
transmembrane protein with a cdc2+/CDC28related kinase activity is required for signaling
from the ER to the nucleus. Cell 74:743–756
Mori T, Ogasawara C, Inada T, Englert M, Beier H,
Takezawa M, Endo T, Yoshihisa T (2010) Dual
functions of yeast tRNA ligase in the unfolded
protein response: unconventional cytoplasmic
splicing of HAC1 pre-mRNA is not sufficient to
release translational attenuation. Mol Biol Cell
21:3722–3734
Mori K, Sant A, Kohno K, Normington K, Gething MJ,
Sambrook JF (1992) A 22 bp cis-acting element is
necessary and sufficient for the induction of the
yeast KAR2 (BiP) gene by unfolded proteins.
EMBO J 11:2583–2593
Mulder HJ, Nikolaev I (2009) HacA-dependent transcriptional switch releases hacA mRNA from a
translational block upon endoplasmic reticulum
stress. Eukaryot Cell 8:665–675
Mulder HJ, Nikolaev I, Madrid SM (2006) HACA, the
transcriptional activator of the unfolded protein
response (UPR) in Aspergillus niger, binds to
partly palindromic UPR elements of the consensus
sequence 5’-CAN(G/a)NTGT/GCCT-3
0 . Fungal
Genet Biol 43:560–572
Mulder HJ, Saloheimo M, Penttila M, Madrid SM (2004)
The transcription factor HACA mediates the
unfolded protein response in Aspergillus niger,
and up-regulates its own transcription. Mol
Genet Genomics MGG 271:130–140
Nadal M, Gold SE (2010) The autophagy genes ATG8
and ATG1 affect morphogenesis and pathogenicity
in Ustilago maydis. Mol Plant Pathol 11:463–478
Ng DT, Spear ED, Walter P (2000) The unfolded protein
response regulates multiple aspects of secretory
3 Genetics of the Unfolded Protein Response in Fungi
73
70:317–343
Levin DE (2011) Regulation of cell wall biogenesis in
Saccharomyces cerevisiae: the cell wall integrity
signaling pathway. Genetics 189:1145–1175
Li H, Korennykh AV, Behrman SL, Walter P (2010)
Mammalian endoplasmic reticulum stress sensor
IRE1 signals by dynamic clustering. Proc Natl
Acad Sci U S A 107:16113–16118
Li W, Okreglak V, Peschek J, Kimmig P, Zubradt M,
Weissman JS, Walter P (2018) Engineering ERstress dependent non-conventional mRNA splicing. elife 7
Li K, Ouyang H, Lu Y, Liang J, Wilson IBH, Jin C (2011)
Repression of N-glycosylation triggers the
unfolded protein response (UPR) and overexpression of cell wall protein and chitin in Aspergillus
fumigatus. Microbiology 157:1968–1979
Lima Pde S, Chung D, Bailao AM, Cramer RA, Soares
CM (2015) Characterization of the Paracoccidioides hypoxia response reveals new insights
into pathogenesis mechanisms of this important
human pathogenic fungus. PLoS Negl Trop Dis 9:
e0004282
Lipatova Z, Segev N (2015) A role for macro-ER-Phagy
in ER quality control. PLoS Genet 11:e1005390
Lo Presti L, Lopez Diaz C, Turra D, Di Pietro A, Hampel
M, Heimel K, Kahmann R (2016) A conserved cochaperone is required for virulence in fungal plant
pathogens. New Phytol 209:1135–1148
Lombrana M, Moralejo FJ, Pinto R, Martin JF (2004)
Modulation of Aspergillus awamori thaumatin
secretion by modification of bipA gene expression.
Appl Environ Microbiol 70:5145–5152
Malavazi I, Goldman GH, Brown NA (2014) The importance of connections between the cell wall integrity
pathway and the unfolded protein response in
filamentous fungi. Brief Funct Genomics
13:456–470
Marschall R, Tudzynski P (2017) The protein disulfide
Isomerase of Botrytis cinerea: an ER protein
involved in protein folding and redox homeostasis
influences NADPH oxidase signaling processes.
Front Microbiol 8:960
Mathioni SM, Belo A, Rizzo CJ, Dean RA, Donofrio NM
(2011) Transcriptome profiling of the rice blast
fungus during invasive plant infection and
in vitro stresses. BMC Genomics 12:49
Merivuori H, Siegler KM, Sands JA, Montenecourt BS
(1985) Regulation of cellulase biosynthesis and
secretion in fungi. Biochem Soc Trans 13:411–414
Miyazaki T, Kohno S (2014) ER stress response mechanisms in the pathogenic yeast Candida glabrata and
their roles in virulence. Virulence 5:365–370
Miyazaki T, Nakayama H, Nagayoshi Y, Kakeya H,
Kohno S (2013) Dissection of Ire1 functions
reveals stress response mechanisms uniquely
evolved in Candida glabrata. PLoS Pathog 9:
e1003160
Mochida K, Oikawa Y, Kimura Y, Kirisako H, Hirano H,
Ohsumi Y, Nakatogawa H (2015) Receptormediated selective autophagy degrades the endoplasmic reticulum and the nucleus. Nature
522:359–362
Monteiro JP, Clemons KV, Mirels LF, Coller JA Jr, Wu
TD, Shankar J, Lopes CR, Stevens DA (2009) Genomic DNA microarray comparison of gene expression patterns in Paracoccidioides brasiliensis
mycelia and yeasts in vitro. Microbiology
155:2795–2808
Montenecourt BS, Nhlapo SD, Trimino-Vazquez H,
Cuskey S, Schamhart DH, Eveleigh DE (1981) Regulatory controls in relation to over-production of
fungal cellulases. Basic Life Sci 18:33–53
Montenegro-Montero A, Goity A, Larrondo LF (2015)
The bZIP transcription factor HAC-1 is involved in
the unfolded protein response and is necessary for
growth on cellulose in Neurospora crassa. PLoS
One 10:e0131415
Mori K, Ma W, Gething MJ, Sambrook J (1993) A
transmembrane protein with a cdc2+/CDC28related kinase activity is required for signaling
from the ER to the nucleus. Cell 74:743–756
Mori T, Ogasawara C, Inada T, Englert M, Beier H,
Takezawa M, Endo T, Yoshihisa T (2010) Dual
functions of yeast tRNA ligase in the unfolded
protein response: unconventional cytoplasmic
splicing of HAC1 pre-mRNA is not sufficient to
release translational attenuation. Mol Biol Cell
21:3722–3734
Mori K, Sant A, Kohno K, Normington K, Gething MJ,
Sambrook JF (1992) A 22 bp cis-acting element is
necessary and sufficient for the induction of the
yeast KAR2 (BiP) gene by unfolded proteins.
EMBO J 11:2583–2593
Mulder HJ, Nikolaev I (2009) HacA-dependent transcriptional switch releases hacA mRNA from a
translational block upon endoplasmic reticulum
stress. Eukaryot Cell 8:665–675
Mulder HJ, Nikolaev I, Madrid SM (2006) HACA, the
transcriptional activator of the unfolded protein
response (UPR) in Aspergillus niger, binds to
partly palindromic UPR elements of the consensus
sequence 5’-CAN(G/a)NTGT/GCCT-3
0 . Fungal
Genet Biol 43:560–572
Mulder HJ, Saloheimo M, Penttila M, Madrid SM (2004)
The transcription factor HACA mediates the
unfolded protein response in Aspergillus niger,
and up-regulates its own transcription. Mol
Genet Genomics MGG 271:130–140
Nadal M, Gold SE (2010) The autophagy genes ATG8
and ATG1 affect morphogenesis and pathogenicity
in Ustilago maydis. Mol Plant Pathol 11:463–478
Ng DT, Spear ED, Walter P (2000) The unfolded protein
response regulates multiple aspects of secretory
3 Genetics of the Unfolded Protein Response in Fungi
73