Grimaldi B, Coiro P, Filetici P, Berge E, Dobosy JR,
Freitag M, Selker EU, Ballario P (2006) The Neurospora crassa white collar-1 dependent blue light
response requires acetylation of histone H3 lysine
14 by NGF-1. Mol Biol Cell 17:4576–4583
Grou CP, Pinto MP, Mendes AV, Domingues P, Azevedo JE (2015) The de novo synthesis of ubiquitin:
identification of deubiquitinases acting on ubiquitin precursors. Sci Rep 5:12836
Gu Q, Wang Z, Sun X, Ji T, Huang H, Yang Y, Zhang H,
Tahir HAS, Wu L, Wu H, Gao X (2017) FvSet2
regulates fungal growth, pathogenicity, and secondary metabolism in Fusarium verticillioides.
Fungal Genet Biol 107:24–30
Haahr P, Borgermann N, Guo X, Typas D, Achuthankutty D, Hoffmann S, Shearer R, Sixma TK, Mailand N (2018) ZUFSP deubiquitylates K63-linked
polyubiquitin chains to promote genome stability.
Mol Cell 70:165–174.e6
Haas H (2014) Fungal siderophore metabolism with a
focus on Aspergillus fumigatus. Nat Prod Rep
31:1266–1276
Hampel M, Jakobi M, Schmitz L, Meyer U, Finkernagel
F, Doehlemann G, Heimel K (2016) Unfolded protein response (UPR) regulator Cib1 controls
expression of genes encoding secreted virulence
factors in Ustilago maydis. PLoS One 11:e0153861
Han Y, Kim M, Lee S, Yun S, Lee Y (2007) A novel F-box
protein involved in sexual development and pathogenesis in Gibberella zeae. Mol Microbiol 63:768–
779
Harting R, Bayram O ¨ , Laubinger K, Valerius O, Braus
GH (2013) Interplay of the fungal sumoylation
network for control of multicellular development.
Mol Microbiol 90:1125–1145
He C, Baba M, Cao Y, Klionsky DJ (2008) Selfinteraction is critical for Atg9 transport and function at the phagophore assembly site during
autophagy. Mol Biol Cell 19:5506–5516
Hedtke M, Rauscher S, Ro ¨hrig J, Rodrı ´guez-Romero J,
Yu Z, Fischer R (2015) Light-dependent gene activation in Aspergillus nidulans is strictly dependent
on phytochrome and involves the interplay of
phytochrome and white collar-regulated histone
H3 acetylation. Mol Microbiol 97:733–745
Heimel K, Freitag J, Hampel M, Ast J, Bolker M, Kamper J (2013) Crosstalk between the unfolded protein response and pathways that regulate
pathogenic development in Ustilago maydis.
Plant Cell 25:4262–4277
Helmstaedt K, Schwier EU, Christmann M, Nahlik K,
Tansey WP (2011) Recruitment of the inhibitor
Cand1 to the cullin substrate adaptor site mediates
interaction to the neddylation site. Mol Biol Cell
22:153–164
Henrikson JC, Hoover AR, Joyner PM, Cichewicz RH
(2009) A chemical epigenetics approach for engineering the in situ biosynthesis of a cryptic natural
product from Aspergillus niger. Org Biomol Chem
7:435–438
Herr A, Fischer R (2014) Improvement of Aspergillus
nidulans penicillin production by targeting AcvA
to peroxisomes. Metab Eng 25:131–139
Hiraishi H, Mochizuki M, Takagi H (2006) Enhancement of stress tolerance in Saccharomyces cerevisiae by overexpression of ubiquitin ligase Rsp5
and ubiquitin-conjugating enzymes. Biosci Biotechnol Biochem 70:2762–2765
Hoeller D, Dikic I (2016) How the proteasome is
degraded. Proc Natl Acad Sci USA 113:13266–
13268
Holighaus G, Rohlfs M (2018) Volatile and non-volatile
fungal oxylipins in fungus-invertebrate interactions. Fungal Ecol 38:28–36
Hutchins AP, Liu S, Diez D, Miranda-Saavedra D (2013)
The repertoires of ubiquitinating and deubiquitinating enzymes in eukaryotic genomes. Mol Biol
Evol 30:1172–1187
Idnurm A, Verma S, Corrochano LM (2010) A glimpse
into the basis of vision in the kingdom Mycota.
Fungal Genet Biol 47:881–892
Inglis DO, Binkley J, Skrzypek MS, Arnaud MB, Cerqueira GC, Shah P, Wymore F, Wortman JR, Sherlock G (2013) Comprehensive annotation of
secondary metabolite biosynthetic genes and
gene clusters of Aspergillus nidulans, A. fumigatus,
A. niger and A. oryzae. BMC Microbiol 13:91
Itoh E, Shigemoto R, Oinuma K-I, Shimizu M, Masuo S,
Takaya N (2017) Sirtuin A regulates secondary
metabolite production by Aspergillus nidulans. J
Gen Appl Microbiol 63:228–235
Izawa M, Takekawa O, Arie T, Teraoka T, Yoshida M,
Kimura M, Kamakura T (2009) Inhibition of histone deacetylase causes reduction of appressorium
formation in the rice blast fungus Magnaporthe
oryzae. J Gen Appl Microbiol 55:489–498
Janevska S, Baumann L, Sieber CMK, Mu ¨nsterko ¨tter M,
Ulrich J, Ka ¨mper J, Gu ¨ldener U, Tudzynski B
(2018) Elucidation of the two H3K36me3 histone
methyltransferases Set2 and Ash1 in Fusarium
fujikuroi unravels their different chromosomal
targets and a major impact of Ash1 on genome
stability. Genetics 208:153–171
Jo ¨hnk B, Bayram O ¨ , Abelmann A, Heinekamp T, Mattern DJ, Brakhage AA, Jacobsen ID, Valerius O,
Braus GH (2016) SCF ubiquitin ligase F-box protein Fbx15 controls nuclear co-repressor localization, stress response and virulence of the human
pathogen Aspergillus fumigatus. PLoS Pathog
12:1–10
Kawauchi M, Iwashita K (2014) Functional analysis of
histone deacetylase and its role in stress response,
drug resistance and solid-state cultivation in
Aspergillus oryzae. J Biosci Bioeng 118:172–176
Kawauchi M, Nishiura M, Iwashita K (2013) Fungalspecific sirtuin HstD coordinates secondary
8 Coordination of Fungal Secondary Metabolism and Development
199
Freitag M, Selker EU, Ballario P (2006) The Neurospora crassa white collar-1 dependent blue light
response requires acetylation of histone H3 lysine
14 by NGF-1. Mol Biol Cell 17:4576–4583
Grou CP, Pinto MP, Mendes AV, Domingues P, Azevedo JE (2015) The de novo synthesis of ubiquitin:
identification of deubiquitinases acting on ubiquitin precursors. Sci Rep 5:12836
Gu Q, Wang Z, Sun X, Ji T, Huang H, Yang Y, Zhang H,
Tahir HAS, Wu L, Wu H, Gao X (2017) FvSet2
regulates fungal growth, pathogenicity, and secondary metabolism in Fusarium verticillioides.
Fungal Genet Biol 107:24–30
Haahr P, Borgermann N, Guo X, Typas D, Achuthankutty D, Hoffmann S, Shearer R, Sixma TK, Mailand N (2018) ZUFSP deubiquitylates K63-linked
polyubiquitin chains to promote genome stability.
Mol Cell 70:165–174.e6
Haas H (2014) Fungal siderophore metabolism with a
focus on Aspergillus fumigatus. Nat Prod Rep
31:1266–1276
Hampel M, Jakobi M, Schmitz L, Meyer U, Finkernagel
F, Doehlemann G, Heimel K (2016) Unfolded protein response (UPR) regulator Cib1 controls
expression of genes encoding secreted virulence
factors in Ustilago maydis. PLoS One 11:e0153861
Han Y, Kim M, Lee S, Yun S, Lee Y (2007) A novel F-box
protein involved in sexual development and pathogenesis in Gibberella zeae. Mol Microbiol 63:768–
779
Harting R, Bayram O ¨ , Laubinger K, Valerius O, Braus
GH (2013) Interplay of the fungal sumoylation
network for control of multicellular development.
Mol Microbiol 90:1125–1145
He C, Baba M, Cao Y, Klionsky DJ (2008) Selfinteraction is critical for Atg9 transport and function at the phagophore assembly site during
autophagy. Mol Biol Cell 19:5506–5516
Hedtke M, Rauscher S, Ro ¨hrig J, Rodrı ´guez-Romero J,
Yu Z, Fischer R (2015) Light-dependent gene activation in Aspergillus nidulans is strictly dependent
on phytochrome and involves the interplay of
phytochrome and white collar-regulated histone
H3 acetylation. Mol Microbiol 97:733–745
Heimel K, Freitag J, Hampel M, Ast J, Bolker M, Kamper J (2013) Crosstalk between the unfolded protein response and pathways that regulate
pathogenic development in Ustilago maydis.
Plant Cell 25:4262–4277
Helmstaedt K, Schwier EU, Christmann M, Nahlik K,
Tansey WP (2011) Recruitment of the inhibitor
Cand1 to the cullin substrate adaptor site mediates
interaction to the neddylation site. Mol Biol Cell
22:153–164
Henrikson JC, Hoover AR, Joyner PM, Cichewicz RH
(2009) A chemical epigenetics approach for engineering the in situ biosynthesis of a cryptic natural
product from Aspergillus niger. Org Biomol Chem
7:435–438
Herr A, Fischer R (2014) Improvement of Aspergillus
nidulans penicillin production by targeting AcvA
to peroxisomes. Metab Eng 25:131–139
Hiraishi H, Mochizuki M, Takagi H (2006) Enhancement of stress tolerance in Saccharomyces cerevisiae by overexpression of ubiquitin ligase Rsp5
and ubiquitin-conjugating enzymes. Biosci Biotechnol Biochem 70:2762–2765
Hoeller D, Dikic I (2016) How the proteasome is
degraded. Proc Natl Acad Sci USA 113:13266–
13268
Holighaus G, Rohlfs M (2018) Volatile and non-volatile
fungal oxylipins in fungus-invertebrate interactions. Fungal Ecol 38:28–36
Hutchins AP, Liu S, Diez D, Miranda-Saavedra D (2013)
The repertoires of ubiquitinating and deubiquitinating enzymes in eukaryotic genomes. Mol Biol
Evol 30:1172–1187
Idnurm A, Verma S, Corrochano LM (2010) A glimpse
into the basis of vision in the kingdom Mycota.
Fungal Genet Biol 47:881–892
Inglis DO, Binkley J, Skrzypek MS, Arnaud MB, Cerqueira GC, Shah P, Wymore F, Wortman JR, Sherlock G (2013) Comprehensive annotation of
secondary metabolite biosynthetic genes and
gene clusters of Aspergillus nidulans, A. fumigatus,
A. niger and A. oryzae. BMC Microbiol 13:91
Itoh E, Shigemoto R, Oinuma K-I, Shimizu M, Masuo S,
Takaya N (2017) Sirtuin A regulates secondary
metabolite production by Aspergillus nidulans. J
Gen Appl Microbiol 63:228–235
Izawa M, Takekawa O, Arie T, Teraoka T, Yoshida M,
Kimura M, Kamakura T (2009) Inhibition of histone deacetylase causes reduction of appressorium
formation in the rice blast fungus Magnaporthe
oryzae. J Gen Appl Microbiol 55:489–498
Janevska S, Baumann L, Sieber CMK, Mu ¨nsterko ¨tter M,
Ulrich J, Ka ¨mper J, Gu ¨ldener U, Tudzynski B
(2018) Elucidation of the two H3K36me3 histone
methyltransferases Set2 and Ash1 in Fusarium
fujikuroi unravels their different chromosomal
targets and a major impact of Ash1 on genome
stability. Genetics 208:153–171
Jo ¨hnk B, Bayram O ¨ , Abelmann A, Heinekamp T, Mattern DJ, Brakhage AA, Jacobsen ID, Valerius O,
Braus GH (2016) SCF ubiquitin ligase F-box protein Fbx15 controls nuclear co-repressor localization, stress response and virulence of the human
pathogen Aspergillus fumigatus. PLoS Pathog
12:1–10
Kawauchi M, Iwashita K (2014) Functional analysis of
histone deacetylase and its role in stress response,
drug resistance and solid-state cultivation in
Aspergillus oryzae. J Biosci Bioeng 118:172–176
Kawauchi M, Nishiura M, Iwashita K (2013) Fungalspecific sirtuin HstD coordinates secondary
8 Coordination of Fungal Secondary Metabolism and Development
199