Heller J, Clave C, Gladieux P, Saupe SJ, Glass NL (2018)
NLR surveillance of essential SEC-9 SNARE proteins induces programmed cell death upon allorecognition in filamentous fungi. Proc Natl Acad
Sci U S A 115:E2292
Hu XJ, Li T, Wang Y, Xiong Y, Wu XH, Zhang DL, Ye
ZQ, Wu YD (2017) Prokaryotic and highlyrepetitive WD40 proteins: a systematic study. Sci
Rep 7:10585
Inohara N, Ogura Y, Chen FF, Muto A, Nunez G (2001)
Human Nod1 confers responsiveness to bacterial
lipopolysaccharides. J Biol Chem 276:2551–2554
Iotti M, Rubini A, Tisserant E, Kholer A, Paolocci F,
Zambonelli A (2012) Self/nonself recognition in
Tuber melanosporum is not mediated by a heterokaryon incompatibility system. Fungal Biol
116:261–275
Jones JD, Dangl JL (2006) The plant immune system.
Nature 444:323–329
Jones JD, Vance RE, Dangl JL (2016) Intracellular
innate immune surveillance devices in plants and
animals. Science 354:aaf6395
Koonin EV, Aravind L (2000) The NACHT family – a
new group of predicted NTPases implicated in
apoptosis and MHC transcription activation.
Trends Biochem Sci 25:223–224
Koonin EV, Aravind L (2002) Origin and evolution of
eukaryotic apoptosis: the bacterial connection.
Cell Death Differ 9:394–404
Kubicek CP, Herrera-Estrella A, Seidl-Seiboth V, Martinez DA, Druzhinina IS, Thon M, Zeilinger S,
Casas-Flores S, Horwitz BA, Mukherjee PK et al
(2011) Comparative genome sequence analysis
underscores mycoparasitism as the ancestral life
style of Trichoderma. Genome Biol 12:R40
Leipe DD, Koonin EV, Aravind L (2004) STAND, a class
of P-loop NTPases including animal and plant
regulators of programmed cell death: multiple,
complex domain architectures, unusual phyletic
patterns, and evolution by horizontal gene transfer. J Mol Biol 343:1–28
Letunic I, Bork P (2018) 20 years of the SMART protein
domain annotation resource. Nucleic Acids Res
46:D493–D496
Li J, McQuade T, Siemer AB, Napetschnig J, Moriwaki K,
Hsiao YS, Damko E, Moquin D, Walz T, McDermott
A et al (2012) The RIP1/RIP3 necrosome forms a
functional amyloid signaling complex required for
programmed necrosis. Cell 150:339–350
Lipinski S, Rosenstiel P (2013) Debug your bugs – how
NLRs shape intestinal host-microbe interactions.
Front Immunol 4:479
Loquet A, Saupe SJ (2017) Diversity of amyloid motifs
in NLR signaling in Fungi. Biomol Ther 7(2):E38
Marold JD, Kavran JM, Bowman GD, Barrick D (2015)
A naturally occurring repeat protein with high
internal sequence identity defines a new class of
TPR-like proteins. Structure 23:2055–2065
Martin F, Aerts A, Ahren D, Brun A, Danchin EG,
Duchaussoy F, Gibon J, Kohler A, Lindquist E,
Pereda V et al (2008) The genome of Laccaria
bicolor provides insights into mycorrhizal symbiosis. Nature 452:88–92
Martino E, Morin E, Grelet GA, Kuo A, Kohler A,
Daghino S, Barry KW, Cichocki N, Clum A, Dockter RB et al (2018) Comparative genomics and
transcriptomics depict ericoid mycorrhizal fungi
as versatile saprotrophs and plant mutualists. New
Phytol 217:1213–1229
Matsuura K, Yashiro T, Shimizu K, Tatsumi S, Tamura
T (2009) Cuckoo fungus mimics termite eggs by
producing the cellulose-digesting enzyme betaglucosidase. Curr Biol 19:30–36
Meunier E, Broz P (2017) Evolutionary convergence
and divergence in NLR function and structure.
Trends Immunol 38:744–757
Mompean M, Li W, Li J, Laage S, Siemer AB, Bozkurt G,
Wu H, McDermott AE (2018) The structure of the
necrosome RIPK1-RIPK3 core, a human heteroamyloid signaling complex. Cell 173(1244–1253):
e1210
Newman AM, Cooper JB (2007) XSTREAM: a practical
algorithm for identification and architecture modeling of tandem repeats in protein sequences. BMC
Bioinform 8:382
Nimma S, Ve T, Williams SJ, Kobe B (2017) Towards
the structure of the TIR-domain signalosome.
Curr Opin Struct Biol 43:122–130
Palma K, Thorgrimsen S, Malinovsky FG, Fiil BK, Nielsen HB, Brodersen P, Hofius D, Petersen M,
Mundy J (2010) Autoimmunity in Arabidopsis
acd11 is mediated by epigenetic regulation of an
immune receptor. PLoS Pathog 6(10):e1001137
Paoletti M (2016) Vegetative incompatibility in fungi:
from recognition to cell death, whatever does the
trick. Fungal Biol Rev 30:152–162
Paoletti M, Saupe SJ (2009) Fungal incompatibility:
evolutionary origin in pathogen defense? BioEssays 31:1201–1210
Paoletti M, Saupe SJ, Clave C (2007) Genesis of a
fungal non-self recognition repertoire. PLoS One
2:e283
Park HH, Lo YC, Lin SC, Wang L, Yang JK, Wu H
(2007) The death domain superfamily in intracellular signaling of apoptosis and inflammation.
Annu Rev Immunol 25:561–586
Peter M, Kohler A, Ohm RA, Kuo A, Krutzmann J,
Morin E, Arend M, Barry KW, Binder M, Choi C
et al (2016) Ectomycorrhizal ecology is imprinted
in the genome of the dominant symbiotic fungus
Cenococcum geophilum. Nat Commun 7:12662
Pinan-Lucarre B, Paoletti M, Clave C (2007) Cell death
by incompatibility in the fungus Podospora.
Semin Cancer Biol 17:101–111
Riek R, Eisenberg DS (2016) The activities of amyloids
from a structural perspective. Nature 539:227–235
140
A. Daskalov et al.
NLR surveillance of essential SEC-9 SNARE proteins induces programmed cell death upon allorecognition in filamentous fungi. Proc Natl Acad
Sci U S A 115:E2292
Hu XJ, Li T, Wang Y, Xiong Y, Wu XH, Zhang DL, Ye
ZQ, Wu YD (2017) Prokaryotic and highlyrepetitive WD40 proteins: a systematic study. Sci
Rep 7:10585
Inohara N, Ogura Y, Chen FF, Muto A, Nunez G (2001)
Human Nod1 confers responsiveness to bacterial
lipopolysaccharides. J Biol Chem 276:2551–2554
Iotti M, Rubini A, Tisserant E, Kholer A, Paolocci F,
Zambonelli A (2012) Self/nonself recognition in
Tuber melanosporum is not mediated by a heterokaryon incompatibility system. Fungal Biol
116:261–275
Jones JD, Dangl JL (2006) The plant immune system.
Nature 444:323–329
Jones JD, Vance RE, Dangl JL (2016) Intracellular
innate immune surveillance devices in plants and
animals. Science 354:aaf6395
Koonin EV, Aravind L (2000) The NACHT family – a
new group of predicted NTPases implicated in
apoptosis and MHC transcription activation.
Trends Biochem Sci 25:223–224
Koonin EV, Aravind L (2002) Origin and evolution of
eukaryotic apoptosis: the bacterial connection.
Cell Death Differ 9:394–404
Kubicek CP, Herrera-Estrella A, Seidl-Seiboth V, Martinez DA, Druzhinina IS, Thon M, Zeilinger S,
Casas-Flores S, Horwitz BA, Mukherjee PK et al
(2011) Comparative genome sequence analysis
underscores mycoparasitism as the ancestral life
style of Trichoderma. Genome Biol 12:R40
Leipe DD, Koonin EV, Aravind L (2004) STAND, a class
of P-loop NTPases including animal and plant
regulators of programmed cell death: multiple,
complex domain architectures, unusual phyletic
patterns, and evolution by horizontal gene transfer. J Mol Biol 343:1–28
Letunic I, Bork P (2018) 20 years of the SMART protein
domain annotation resource. Nucleic Acids Res
46:D493–D496
Li J, McQuade T, Siemer AB, Napetschnig J, Moriwaki K,
Hsiao YS, Damko E, Moquin D, Walz T, McDermott
A et al (2012) The RIP1/RIP3 necrosome forms a
functional amyloid signaling complex required for
programmed necrosis. Cell 150:339–350
Lipinski S, Rosenstiel P (2013) Debug your bugs – how
NLRs shape intestinal host-microbe interactions.
Front Immunol 4:479
Loquet A, Saupe SJ (2017) Diversity of amyloid motifs
in NLR signaling in Fungi. Biomol Ther 7(2):E38
Marold JD, Kavran JM, Bowman GD, Barrick D (2015)
A naturally occurring repeat protein with high
internal sequence identity defines a new class of
TPR-like proteins. Structure 23:2055–2065
Martin F, Aerts A, Ahren D, Brun A, Danchin EG,
Duchaussoy F, Gibon J, Kohler A, Lindquist E,
Pereda V et al (2008) The genome of Laccaria
bicolor provides insights into mycorrhizal symbiosis. Nature 452:88–92
Martino E, Morin E, Grelet GA, Kuo A, Kohler A,
Daghino S, Barry KW, Cichocki N, Clum A, Dockter RB et al (2018) Comparative genomics and
transcriptomics depict ericoid mycorrhizal fungi
as versatile saprotrophs and plant mutualists. New
Phytol 217:1213–1229
Matsuura K, Yashiro T, Shimizu K, Tatsumi S, Tamura
T (2009) Cuckoo fungus mimics termite eggs by
producing the cellulose-digesting enzyme betaglucosidase. Curr Biol 19:30–36
Meunier E, Broz P (2017) Evolutionary convergence
and divergence in NLR function and structure.
Trends Immunol 38:744–757
Mompean M, Li W, Li J, Laage S, Siemer AB, Bozkurt G,
Wu H, McDermott AE (2018) The structure of the
necrosome RIPK1-RIPK3 core, a human heteroamyloid signaling complex. Cell 173(1244–1253):
e1210
Newman AM, Cooper JB (2007) XSTREAM: a practical
algorithm for identification and architecture modeling of tandem repeats in protein sequences. BMC
Bioinform 8:382
Nimma S, Ve T, Williams SJ, Kobe B (2017) Towards
the structure of the TIR-domain signalosome.
Curr Opin Struct Biol 43:122–130
Palma K, Thorgrimsen S, Malinovsky FG, Fiil BK, Nielsen HB, Brodersen P, Hofius D, Petersen M,
Mundy J (2010) Autoimmunity in Arabidopsis
acd11 is mediated by epigenetic regulation of an
immune receptor. PLoS Pathog 6(10):e1001137
Paoletti M (2016) Vegetative incompatibility in fungi:
from recognition to cell death, whatever does the
trick. Fungal Biol Rev 30:152–162
Paoletti M, Saupe SJ (2009) Fungal incompatibility:
evolutionary origin in pathogen defense? BioEssays 31:1201–1210
Paoletti M, Saupe SJ, Clave C (2007) Genesis of a
fungal non-self recognition repertoire. PLoS One
2:e283
Park HH, Lo YC, Lin SC, Wang L, Yang JK, Wu H
(2007) The death domain superfamily in intracellular signaling of apoptosis and inflammation.
Annu Rev Immunol 25:561–586
Peter M, Kohler A, Ohm RA, Kuo A, Krutzmann J,
Morin E, Arend M, Barry KW, Binder M, Choi C
et al (2016) Ectomycorrhizal ecology is imprinted
in the genome of the dominant symbiotic fungus
Cenococcum geophilum. Nat Commun 7:12662
Pinan-Lucarre B, Paoletti M, Clave C (2007) Cell death
by incompatibility in the fungus Podospora.
Semin Cancer Biol 17:101–111
Riek R, Eisenberg DS (2016) The activities of amyloids
from a structural perspective. Nature 539:227–235
140
A. Daskalov et al.