63%
72%
51%
66%
53%
90%
71%
36%
CuCN (10 mol%)
I 2 , NaCN, tBuOLi, 110 °C
H
phenanthroline (20 mol%)
CN
N
O
CN
N
S
CN
N
N
CN
Me
N
N
N
N
CN
Me
O
Me
O
Me
N
N
N
CN
F
O
CN
Ph
CN
CN
Ar
Ar
Scheme 3.45 Cu-catalyzed oxidative cyanation of heterocycles
Scheme 3.46 Cu(II)-catalyzed oxidative C–H chlorination of 2-arylpyridines
72%
51%
66%
53%
90%
71%
36%
CuCN (10 mol%)
I 2 , NaCN, tBuOLi, 110 °C
H
phenanthroline (20 mol%)
CN
N
O
CN
N
S
CN
N
N
CN
Me
N
N
N
N
CN
Me
O
Me
O
Me
N
N
N
CN
F
O
CN
Ph
CN
CN
Ar
Ar
Scheme 3.45 Cu-catalyzed oxidative cyanation of heterocycles
Scheme 3.46 Cu(II)-catalyzed oxidative C–H chlorination of 2-arylpyridines