190
5.4 Conclusion
In conclusion, fourth-generation oxidative cross-coupling reactions have been
developed in recent years, which represent a useful and environmental friendly
strategy to form a C-X bond from the corresponding C-H and X-H (X = carbon or
heteroatom) bonds. In this reaction system, no external oxidant is required, and H 2
gas is released as the only by-product. Therefore, we believe this sustainable bond
construction methodology will become an interesting alternative to well-established
cross-coupling reactions.
References
1. Liu Q, Wu L-Z (2017) Recent advances in visible-light-driven organic reactions. Natl Sci Rev
4:359–380
2. He R, Huang ZT, Zheng QY, Wang C (2014) Manganese-catalyzed dehydrogenative
[4+2] annulation of N-H imines and alkynes by C-H/N-H activation. Angew Chem Int Ed
53:4950–4953
3. He K-H, Zhang W-D, Yang M-Y, Tang K-L, Qu M, Ding Y-S, Li Y (2016) Redox-divergent
hydrogen-retentive or hydrogen-releasing synthesis of 3,4-Dihydroisoquinolines or
Isoquinolines. Org Lett 18:2840–2843
Scheme 5.50 Proposed mechanism for electrocatalytic intramolecular oxidative annulation of
N-aryl enamines
W. Ai et al.
5.4 Conclusion
In conclusion, fourth-generation oxidative cross-coupling reactions have been
developed in recent years, which represent a useful and environmental friendly
strategy to form a C-X bond from the corresponding C-H and X-H (X = carbon or
heteroatom) bonds. In this reaction system, no external oxidant is required, and H 2
gas is released as the only by-product. Therefore, we believe this sustainable bond
construction methodology will become an interesting alternative to well-established
cross-coupling reactions.
References
1. Liu Q, Wu L-Z (2017) Recent advances in visible-light-driven organic reactions. Natl Sci Rev
4:359–380
2. He R, Huang ZT, Zheng QY, Wang C (2014) Manganese-catalyzed dehydrogenative
[4+2] annulation of N-H imines and alkynes by C-H/N-H activation. Angew Chem Int Ed
53:4950–4953
3. He K-H, Zhang W-D, Yang M-Y, Tang K-L, Qu M, Ding Y-S, Li Y (2016) Redox-divergent
hydrogen-retentive or hydrogen-releasing synthesis of 3,4-Dihydroisoquinolines or
Isoquinolines. Org Lett 18:2840–2843
Scheme 5.50 Proposed mechanism for electrocatalytic intramolecular oxidative annulation of
N-aryl enamines
W. Ai et al.