134
10 mol% CuCl
2 equiv DTBP
0.001 mol% tBuOK
120 °C, 24 h
R
NH 2
O
+
H
R
N
H
O
H
H H
R
N
H
O
Ph
N
H
O
84%
N
H
O
83%
MeO
N
H
O
71%
F
N
H
O
71%
N
H
O
55%
O 2 N
N
H
O
67%
F 3 C
Br
N
H
O
80%
N
70%
N
H
O
80%
O
Scheme 4.53 Amidation of benzylic hydrocarbons
1 mol% CuBr
2 equiv TBHP
MeCN, 80°C, 12 h
R
H
O
+ HN S R
1
R
2
O
N S R 1
R 2
O
R
O
R
H
O
TBHP
Cu(II)L n
R
O
HN S R 1
R 2
O
TBHP
Cu(II)L n
S R 1
R 2
O
H
N
Ln(II)Cu
N S R 1
R
2
O
R
O
Scheme 4.54 C-H/N-H functionalization
W. Liu