131
20 mol% AgNO 3
2 equiv K 2 S 2 O 8
N
R 3
O
100 °C, 12 h
CH 3 CN/H 2 O
R 1
N
R 1
R 3
O
R 2
R 2
N
R 3
O
100°C, 12 h
CH 3 CN/H 2 O
R 1
N
R 1
R 3
O
R 2
R 2
HO 2 C
R
O
HO 2 C
R
O
R
R
O
O
+
+
N
Ph
O
O
79%
N
Ph
O
O
74%
Cl
N
Ph
O
O
72%
S
N
Ph
O
O
82%
N
Ph
O
O
72%
N
Ph
O
O
84%
Ph
Ph
CN
N
Ph
O
O
78%
N
Ph
O
O
81%
Cl
N
Ph
O
O
83%
S
N
Ph
O
O
85%
N
Ph
O
O
90%
N
Ph
O
O
77%
Ph
CN
20 mol% AgNO 3
4 equiv K 2 S 2 O 8
Scheme 4.49 Decarboxylative acylation of acrylamides to yield six-member rings
4 Oxidative Radical Couplings