102
N
R
H
10 mol% Pd(OAc) 2
2 equiv t-BuOOt-Bu
150 °C, 12 h
N
R
CH 3
up to 95%
Scheme 4.5 Methylation
of 2-phenylpyridines
N
R
H
10 mol% Ru catalyst
4 equiv t-BuOOt-Bu
air, 135 °C
N
R
up to 75%
+ H
excess
+
N
R
Scheme 4.6 Oxidative alkylation of 2-phenylpyridines
DG
H
R
1
10 mol% Pd (OAc) 2
2 equiv TBHP
120 °C
+ H 3 C
DG
R
1
O
10 equiv.
O
N
85%
O
N
78%
O
N
90%
O
N
88%
O
O
81%
N
OMe
O
O
85%
N
OMe
O
O
83%
N
OMe
O
N
85%
9 0%
Me
MeO
O
N
Me
MeO
O
N
65%
Me
MeO
Br
R
2
R
2
Scheme 4.7 Oxidative Pd-catalyzed ortho-aroylation
W. Liu