4 Conclusion
In the past decade, catalytic organometallic C(sp
3
)–H activation has undergone
major progress and has become a powerful tool to create C(sp
3 )–X bonds in a very
direct manner. An increasing number of applications of the newly developed
methods have been reported, both in natural product and API synthesis. The use
of C–H bond functionalization in a strategic manner in retrosynthetic analysis is an
emerging concept that will deeply impact organic synthesis on the long term, by
improving atom and step economy and thus overall efficiency. However, the field is
still in its infancy, as one is far from being able to selectively functionalize a given
C–H bond in a given organic molecule, and many exciting developments and
applications lie ahead.
Scheme 17 Total synthesis of aeruginosins featuring two strategic Pd-catalyzed C–H activation
reactions
150
D. Dailler et al.
In the past decade, catalytic organometallic C(sp
3
)–H activation has undergone
major progress and has become a powerful tool to create C(sp
3 )–X bonds in a very
direct manner. An increasing number of applications of the newly developed
methods have been reported, both in natural product and API synthesis. The use
of C–H bond functionalization in a strategic manner in retrosynthetic analysis is an
emerging concept that will deeply impact organic synthesis on the long term, by
improving atom and step economy and thus overall efficiency. However, the field is
still in its infancy, as one is far from being able to selectively functionalize a given
C–H bond in a given organic molecule, and many exciting developments and
applications lie ahead.
Scheme 17 Total synthesis of aeruginosins featuring two strategic Pd-catalyzed C–H activation
reactions
150
D. Dailler et al.