72
N. R. Jena et al.
3.4.2 OH Radical Scavengers
The hydroxyl radical is the most reactive ROS present in biological systems. Urocanic acid (UCA) (Fig. 3.7d), a metabolite of histidine, is located in the upper layers
of the human skin epidermis and acts as an absorber of UV-radiation. It has been recently shown that UCA can effectively scavenge OH radicals [142]. As high energy
radiation produces OH
•
by water splitting and dissociation of H 2 O 2 , UCA can play
a vital role in protecting genome from OH
•
mediated mutagenesis.
Fig. 3.7 Structures of some potential ROS/RNOS scavangers [133]
N. R. Jena et al.
3.4.2 OH Radical Scavengers
The hydroxyl radical is the most reactive ROS present in biological systems. Urocanic acid (UCA) (Fig. 3.7d), a metabolite of histidine, is located in the upper layers
of the human skin epidermis and acts as an absorber of UV-radiation. It has been recently shown that UCA can effectively scavenge OH radicals [142]. As high energy
radiation produces OH
•
by water splitting and dissociation of H 2 O 2 , UCA can play
a vital role in protecting genome from OH
•
mediated mutagenesis.
Fig. 3.7 Structures of some potential ROS/RNOS scavangers [133]