484
N. Ya. Golovenko et al.
Preparation
name
Skeleton X
R
1
R
2
R
3
R
4
1
2
3
4
5
6
7
Alprazolam B
N
CH 3
H
Ph
Cl
Bromazepam A
O
H
H
2–pyridyl
Br
Halazepam A
O
CH 2 CF 3
H
Ph
Cl
Gidazepam A
O
CH 2 –CO–NHNH 2 H
Ph
Br
Diazepam
A
O
CH 3
H
Ph
Cl
Estazolam
B
N
H
H
Ph
Cl
Camazepam A
O
CH 3
O–CO–N(CH 3 ) 2
Ph
Cl
Quazepam A
S
CH 3
H
o–F–Ph
Cl
Clobazam
C
CH 3
Ph
Cl
Clonazepam A
O
H
H
o–Cl–Ph
NO 2
Clorazepate A
O
H
COOK
Ph
Cl
Lorazepam A
O
H
OH
o–Cl–Ph
Cl
Medazepam A
2H
CH 3
H
Ph
Cl
Mendon
A
O
H
COOH
Ph
Cl
Midazolam B
C
CH 3
H
o–F–Ph
Cl
Nitrazepam A
O
H
H
Ph
NO 2
Nordazepam A
O
H
H
Ph
Cl
Oxazepam A
O
H
OH
Ph
Cl
Pinazepam A
O
CH 2 CCH
H
Ph
Cl
Prazepam
A
O
CH 2 –cyclopropyl H
1–cyclohexenyl
Cl
Temazepam A
O
CH 3
OH
Ph
Cl
Tofisopam D
–
C 2 H 5
–
thoxyphenyl
OCH 3
Table 14.6  Investigated compounds
N
N
X
R3
R1
R4
R2
A
N
N
X
N
R3
R4
R1
R2
B
N
N
O
R3
R4
R1
O
C
N
N
R3
R4
R1
O
D
N
+
N
R3
R4
NHCH 3
O
R1
E
N
N
O
R4
N
R1
F