414
P. M. Vassiliev et al.
presence and extent of the various types of pharmacological activity of the various
salts of organic compounds in the most diverse chemical classes.
12.5.2 Supramolecular Compounds
The synthesis of supramolecular complexes of known drugs offers a promising approach to novel drug search. For example, let us look at the development of clathrates of nifedipine, allapinin, fluoxetine and phenibut with glycyrrhizinic acid and
stevioside, which showed effects exceeding those of the nonclathrated compounds
by 10–290 times [88].
Fig. 12.6 Glycyrrhizinic acid (XII) and condensed azole derivatives with antioxidant (XIII) and
antiarrhythmic (XIV) activity
P. M. Vassiliev et al.
presence and extent of the various types of pharmacological activity of the various
salts of organic compounds in the most diverse chemical classes.
12.5.2 Supramolecular Compounds
The synthesis of supramolecular complexes of known drugs offers a promising approach to novel drug search. For example, let us look at the development of clathrates of nifedipine, allapinin, fluoxetine and phenibut with glycyrrhizinic acid and
stevioside, which showed effects exceeding those of the nonclathrated compounds
by 10–290 times [88].
Fig. 12.6 Glycyrrhizinic acid (XII) and condensed azole derivatives with antioxidant (XIII) and
antiarrhythmic (XIV) activity