354
A. Zakharov and A. Lagunin
Activity name
N
AUC, %
5 Hydroxytryptamine uptake inhibitor
4311
98.5
ATP-binding cassette G2 inhibitor
44
96.9
Adenosine uptake inhibitor
55
100.0
Adrenaline uptake inhibitor
2366
98.8
Amino acid-polyamine-organocation (APC) transporter
antagonist
82
100.0
Apical sodium codependent bile acid transporter inhibitor
16
100.0
Cationic amino acid transporter 4 inhibitor
32
100.0
Dopamine transporter inhibitor
1221
99.1
Dopamine uptake inhibitor
1848
99.2
Electron transport complex I inhibitor
26
98.5
Endocannabinoid uptake inhibitor
29
99.2
Equilibrative nucleoside transport protein 1 inhibitor
97
99.5
Equilibrative nucleoside transport protein inhibitor
127
99.5
Excitatory amino acid transporter 1 inhibitor
33
99.9
Excitatory amino acid transporter 2 inhibitor
44
99.9
Excitatory amino acid transporter 3 inhibitor
10
100.0
Fatty acid transport protein 4 inhibitor
19
00.0
GABA transporter 1 inhibitor
150
99.6
GABA transporter 2 inhibitor
11
98.9
GABA transporter inhibitor
157
99.4
GABA uptake inhibitor
68
99.3
Glycine transporter 1 inhibitor
466
99.7
Glycine transporter 2 inhibitor
74
98.4
Glycine transporter inhibitor
550
99.2
Ileal bile acid transport inhibitor
144
99.8
Monoamine uptake inhibitor
41
91.6
Multidrug resistance-associated protein 1 inhibitor
223
96.7
Multidrug resistance-associated protein inhibitor
224
96.2
Neuronal K-Cl cotransporter inhibitor
17
91.1
Nucleoside transporters inhibitor
18
99.9
P-glycoprotein 1 inhibitor
450
93.6
P-glycoprotein 3 inhibitor
62
92.2
P-glycoprotein inhibitor
644
93.4
P-glycoprotein substrate
59
85.1
P2 nucleoside transporter inhibitor
11
100.0
Phosphate transporter inhibitor
26
98.1
Proline transporter inhibitor
23
100.0
Sodium/bile acid cotransporter inhibitor
16
97.0
Sodium/calcium exchanger 1 inhibitor
25
97.3
Sodium/calcium exchanger inhibitor
109
98.7
Sodium/glucose cotransporter 1 inhibitor
180
99.2
Sodium/glucose cotransporter 2 inhibitor
425
99.8
Sodium/hydrogen exchanger 1 inhibitor
296
99.9
Sodium/hydrogen exchanger 2 inhibitor
157
100.0
Sodium/hydrogen exchanger 3 inhibitor
220
99.9
Solute carrier family 22 member 12 inhibitor
19
100.0
Tetracycline antiport transporter antagonist
36
100.0
Table 11.14 Interactions with transport proteins and transport systems predicted by PASS 2012
A. Zakharov and A. Lagunin
Activity name
N
AUC, %
5 Hydroxytryptamine uptake inhibitor
4311
98.5
ATP-binding cassette G2 inhibitor
44
96.9
Adenosine uptake inhibitor
55
100.0
Adrenaline uptake inhibitor
2366
98.8
Amino acid-polyamine-organocation (APC) transporter
antagonist
82
100.0
Apical sodium codependent bile acid transporter inhibitor
16
100.0
Cationic amino acid transporter 4 inhibitor
32
100.0
Dopamine transporter inhibitor
1221
99.1
Dopamine uptake inhibitor
1848
99.2
Electron transport complex I inhibitor
26
98.5
Endocannabinoid uptake inhibitor
29
99.2
Equilibrative nucleoside transport protein 1 inhibitor
97
99.5
Equilibrative nucleoside transport protein inhibitor
127
99.5
Excitatory amino acid transporter 1 inhibitor
33
99.9
Excitatory amino acid transporter 2 inhibitor
44
99.9
Excitatory amino acid transporter 3 inhibitor
10
100.0
Fatty acid transport protein 4 inhibitor
19
00.0
GABA transporter 1 inhibitor
150
99.6
GABA transporter 2 inhibitor
11
98.9
GABA transporter inhibitor
157
99.4
GABA uptake inhibitor
68
99.3
Glycine transporter 1 inhibitor
466
99.7
Glycine transporter 2 inhibitor
74
98.4
Glycine transporter inhibitor
550
99.2
Ileal bile acid transport inhibitor
144
99.8
Monoamine uptake inhibitor
41
91.6
Multidrug resistance-associated protein 1 inhibitor
223
96.7
Multidrug resistance-associated protein inhibitor
224
96.2
Neuronal K-Cl cotransporter inhibitor
17
91.1
Nucleoside transporters inhibitor
18
99.9
P-glycoprotein 1 inhibitor
450
93.6
P-glycoprotein 3 inhibitor
62
92.2
P-glycoprotein inhibitor
644
93.4
P-glycoprotein substrate
59
85.1
P2 nucleoside transporter inhibitor
11
100.0
Phosphate transporter inhibitor
26
98.1
Proline transporter inhibitor
23
100.0
Sodium/bile acid cotransporter inhibitor
16
97.0
Sodium/calcium exchanger 1 inhibitor
25
97.3
Sodium/calcium exchanger inhibitor
109
98.7
Sodium/glucose cotransporter 1 inhibitor
180
99.2
Sodium/glucose cotransporter 2 inhibitor
425
99.8
Sodium/hydrogen exchanger 1 inhibitor
296
99.9
Sodium/hydrogen exchanger 2 inhibitor
157
100.0
Sodium/hydrogen exchanger 3 inhibitor
220
99.9
Solute carrier family 22 member 12 inhibitor
19
100.0
Tetracycline antiport transporter antagonist
36
100.0
Table 11.14 Interactions with transport proteins and transport systems predicted by PASS 2012