Chapter 8
Segmentation of Optic Disc
and Cup-to-Disc Ratio Quantification
Based on OCT Scans
Menglin Wu, Theodore Leng, Luis de Sisternes, Daniel L. Rubin
and Qiang Chen
With optical nerve head centered OCT imaging, this special region can be visualized
in 3-D, enabling detailed quantification of its structure. In this chapter, an automated
algorithm is presented for optic disc segmentation in 3-D spectral domain optical
coherence tomography, based on which the cup-to-disc ratio an important indicator
of early glaucoma can be calculated.
8.1 Introduction
Glaucoma is a chronic neurodegenerative disease of the optic nerve, which demonstrates classic structural characteristics including cupping of the optic nerve head,
focal and diffuse retinal rim loss, and nerve fiber layer defects [1]. There is a need to
identify early internal structural changes in glaucoma. The cup-to-disc (C/D) ratio
is an important indicator for evaluating the glaucomatous changes of the optic nerve
head (ONH) [2]. To quantify the ratio, specialists commonly perform planimetry
M. Wu
School of Computer Science and Technology,
Nanjing Tech University, Nanjing, China
T. Leng
Byers Eye Institute at Stanford, Stanford University School of Medicine,
Palo Alto, USA
L. de Sisternes · D. L. Rubin
Department of Radiology and Medicine (Biomedical Informatics Research)
and Ophthalmology, Stanford University School of Medicine, Stanford, USA
Q. Chen (B)
School of Computer Science and Engineering, Nanjing University of Science
and Technology, Nanjing, China
e-mail: chen2qiang@njust.edu.cn
© Science Press and Springer Nature Singapore Pte Ltd. 2019
X. Chen et al. (eds.), Retinal Optical Coherence Tomography Image Analysis,
Biological and Medical Physics, Biomedical Engineering,
https://doi.org/10.1007/978-981-13-1825-2_8
193
Segmentation of Optic Disc
and Cup-to-Disc Ratio Quantification
Based on OCT Scans
Menglin Wu, Theodore Leng, Luis de Sisternes, Daniel L. Rubin
and Qiang Chen
With optical nerve head centered OCT imaging, this special region can be visualized
in 3-D, enabling detailed quantification of its structure. In this chapter, an automated
algorithm is presented for optic disc segmentation in 3-D spectral domain optical
coherence tomography, based on which the cup-to-disc ratio an important indicator
of early glaucoma can be calculated.
8.1 Introduction
Glaucoma is a chronic neurodegenerative disease of the optic nerve, which demonstrates classic structural characteristics including cupping of the optic nerve head,
focal and diffuse retinal rim loss, and nerve fiber layer defects [1]. There is a need to
identify early internal structural changes in glaucoma. The cup-to-disc (C/D) ratio
is an important indicator for evaluating the glaucomatous changes of the optic nerve
head (ONH) [2]. To quantify the ratio, specialists commonly perform planimetry
M. Wu
School of Computer Science and Technology,
Nanjing Tech University, Nanjing, China
T. Leng
Byers Eye Institute at Stanford, Stanford University School of Medicine,
Palo Alto, USA
L. de Sisternes · D. L. Rubin
Department of Radiology and Medicine (Biomedical Informatics Research)
and Ophthalmology, Stanford University School of Medicine, Stanford, USA
Q. Chen (B)
School of Computer Science and Engineering, Nanjing University of Science
and Technology, Nanjing, China
e-mail: chen2qiang@njust.edu.cn
© Science Press and Springer Nature Singapore Pte Ltd. 2019
X. Chen et al. (eds.), Retinal Optical Coherence Tomography Image Analysis,
Biological and Medical Physics, Biomedical Engineering,
https://doi.org/10.1007/978-981-13-1825-2_8
193