129
Silva JM, Pereira CV, Mano F, Silva E, Castro VIB, Sá-Nogueira I, Reis RL, Paiva A, Matias A,
Duarte ARC (2019b) Therapeutic role of deep eutectic solvents based on menthol and saturated fatty acids on wound healing. ACS Appl Bio Mater 2:4346–4355. https://doi.org/10.1021/
acsabm.9b00598
Silva JM, Silva E, Reis RL, Duarte ARC (2019c) A closer look in the antimicrobial properties of deep eutectic solvents based on fatty acids. Sustain Chem Pharm 14:1–9. https://doi.
org/10.1016/j.scp.2019.100192
Sivapragasam M, Moniruzzaman M, Goto M (2016) Recent advances in exploiting ionic liquids
for biomolecules: solubility, stability and applications. Biotechnol J 11:1000–1013. https://doi.
org/10.1002/biot.201500603
Stott PW, Williams AC, Barry BW (1998) Transdermal delivery from eutectic systems: enhanced
permeation of a model drug, ibuprofen. J Control Release 50:297–308. https://doi.org/10.1016/
S0168-3659(97)00153-3
Tuntarawongsa S, Phaechamud T (2012) Polymeric eutectic system. Adv Mater Res 528:180–183.
https://doi.org/10.4028/www.scientific.net/AMR.528.180
Vanda H, Dai Y, Wilson EG, Verpoorte R, Choi YH (2018) Green solvents from ionic liquids and
deep eutectic solvents to natural deep eutectic solvents. C R Chim 21:628–638. https://doi.
org/10.1016/j.crci.2018.04.002
Varma MVS, Khandavilli S, Ashokraj Y, Jain A, Dhanikula A, Sood A, Thomas NS, Pillai O,
Sharma P, Gandhi R, Agrawal S, Nair V, Panchagnula R (2004) Biopharmaceutic classification
system: a scientific framework for pharmacokinetic optimization in drug research. Curr Drug
Metab 5:375–388. https://doi.org/10.2174/1389200043335423
Warner JC, Cannon AS, Dye KM (2004) Green chemistry. Environ Impact Assess Rev 24:775–799.
https://doi.org/10.1016/j.eiar.2004.06.006
Welton T (2015) Solvents and sustainable chemistry. Proc R Soc Lond A 471:20150502. https://
doi.org/10.1098/rspa.2015.0502
Wojnarowska Z, Smolka W, Zotova J, Knapik-Kowalczuk J, Sherif A, Tajber L, Paluch M (2018)
The effect of electrostatic interactions on the formation of pharmaceutical eutectics. Phys
Chem Chem Phys 20:27361–27367. https://doi.org/10.1039/c8cp05905e
Woolfson AD, Malcolm RK, Campbell K, Jones DS, Russell JA (2000) Rheological, mechanical
and membrane penetration properties of novel dual drug systems for percutaneous delivery. J
Control Release 67:395–408. https://doi.org/10.1016/S0168-3659(00)00230-3
Xin R, Qi S, Zeng C, Khan FI, Yang B, Wang Y (2017) A functional natural deep eutectic solvent based on trehalose: structural and physicochemical properties. Food Chem 217:560–567.
https://doi.org/10.1016/j.foodchem.2016.09.012
Yang Z (2018) Natural deep eutectic solvents and their applications in biotechnology. Adv
Biochem Eng Biotechnol. https://doi.org/10.1007/10_2018_67
Yin L, Jiang S (2018) Evaluation of EMLA cream for relieving pain during needle insertion
on totally implantable venous access device. J Vascular Access 19:634–638. https://doi.
org/10.1177/1129729818768182
Zainal-Abidin MH, Hayyan M, Ngoh GC, Wong WF, Looi CY (2019) Emerging frontiers of deep
eutectic solvents in drug discovery and drug delivery systems. J Control Release 316:168–195.
https://doi.org/10.1016/j.jconrel.2019.09.019
Zainal-Abidin MH, Hayyan M, Ngoh GC, Wong WF (2019) Doxorubicin loading on functional
graphene as a promising nanocarrier using ternary deep eutectic solvent systems. ACS Omega
5:1656–1668. https://doi.org/10.1021/acsomega.9b03709
Zakrewsky M, Banerjee A, Apte S, Kern TL, Jones MR, Sesto RED, Koppisch AT, Fox DT,
Mitragotri S (2016) Choline and geranate deep eutectic solvent as a broad-spectrum antiseptic
agent for preventive and therapeutic applications. Adv Healthc Mater 5:1282–1289. https://doi.
org/10.1002/adhm.201600086
3 Therapeutic Deep Eutectic Systems for the Enhancement of Drug Bioavailability
Silva JM, Pereira CV, Mano F, Silva E, Castro VIB, Sá-Nogueira I, Reis RL, Paiva A, Matias A,
Duarte ARC (2019b) Therapeutic role of deep eutectic solvents based on menthol and saturated fatty acids on wound healing. ACS Appl Bio Mater 2:4346–4355. https://doi.org/10.1021/
acsabm.9b00598
Silva JM, Silva E, Reis RL, Duarte ARC (2019c) A closer look in the antimicrobial properties of deep eutectic solvents based on fatty acids. Sustain Chem Pharm 14:1–9. https://doi.
org/10.1016/j.scp.2019.100192
Sivapragasam M, Moniruzzaman M, Goto M (2016) Recent advances in exploiting ionic liquids
for biomolecules: solubility, stability and applications. Biotechnol J 11:1000–1013. https://doi.
org/10.1002/biot.201500603
Stott PW, Williams AC, Barry BW (1998) Transdermal delivery from eutectic systems: enhanced
permeation of a model drug, ibuprofen. J Control Release 50:297–308. https://doi.org/10.1016/
S0168-3659(97)00153-3
Tuntarawongsa S, Phaechamud T (2012) Polymeric eutectic system. Adv Mater Res 528:180–183.
https://doi.org/10.4028/www.scientific.net/AMR.528.180
Vanda H, Dai Y, Wilson EG, Verpoorte R, Choi YH (2018) Green solvents from ionic liquids and
deep eutectic solvents to natural deep eutectic solvents. C R Chim 21:628–638. https://doi.
org/10.1016/j.crci.2018.04.002
Varma MVS, Khandavilli S, Ashokraj Y, Jain A, Dhanikula A, Sood A, Thomas NS, Pillai O,
Sharma P, Gandhi R, Agrawal S, Nair V, Panchagnula R (2004) Biopharmaceutic classification
system: a scientific framework for pharmacokinetic optimization in drug research. Curr Drug
Metab 5:375–388. https://doi.org/10.2174/1389200043335423
Warner JC, Cannon AS, Dye KM (2004) Green chemistry. Environ Impact Assess Rev 24:775–799.
https://doi.org/10.1016/j.eiar.2004.06.006
Welton T (2015) Solvents and sustainable chemistry. Proc R Soc Lond A 471:20150502. https://
doi.org/10.1098/rspa.2015.0502
Wojnarowska Z, Smolka W, Zotova J, Knapik-Kowalczuk J, Sherif A, Tajber L, Paluch M (2018)
The effect of electrostatic interactions on the formation of pharmaceutical eutectics. Phys
Chem Chem Phys 20:27361–27367. https://doi.org/10.1039/c8cp05905e
Woolfson AD, Malcolm RK, Campbell K, Jones DS, Russell JA (2000) Rheological, mechanical
and membrane penetration properties of novel dual drug systems for percutaneous delivery. J
Control Release 67:395–408. https://doi.org/10.1016/S0168-3659(00)00230-3
Xin R, Qi S, Zeng C, Khan FI, Yang B, Wang Y (2017) A functional natural deep eutectic solvent based on trehalose: structural and physicochemical properties. Food Chem 217:560–567.
https://doi.org/10.1016/j.foodchem.2016.09.012
Yang Z (2018) Natural deep eutectic solvents and their applications in biotechnology. Adv
Biochem Eng Biotechnol. https://doi.org/10.1007/10_2018_67
Yin L, Jiang S (2018) Evaluation of EMLA cream for relieving pain during needle insertion
on totally implantable venous access device. J Vascular Access 19:634–638. https://doi.
org/10.1177/1129729818768182
Zainal-Abidin MH, Hayyan M, Ngoh GC, Wong WF, Looi CY (2019) Emerging frontiers of deep
eutectic solvents in drug discovery and drug delivery systems. J Control Release 316:168–195.
https://doi.org/10.1016/j.jconrel.2019.09.019
Zainal-Abidin MH, Hayyan M, Ngoh GC, Wong WF (2019) Doxorubicin loading on functional
graphene as a promising nanocarrier using ternary deep eutectic solvent systems. ACS Omega
5:1656–1668. https://doi.org/10.1021/acsomega.9b03709
Zakrewsky M, Banerjee A, Apte S, Kern TL, Jones MR, Sesto RED, Koppisch AT, Fox DT,
Mitragotri S (2016) Choline and geranate deep eutectic solvent as a broad-spectrum antiseptic
agent for preventive and therapeutic applications. Adv Healthc Mater 5:1282–1289. https://doi.
org/10.1002/adhm.201600086
3 Therapeutic Deep Eutectic Systems for the Enhancement of Drug Bioavailability