128
Patel RD, Raval MK, Bagathariya AA, Sheth NR (2019) Functionality improvement of nimesulide
by eutectic formation with nicotinamide: exploration using temperature-composition phase
diagram. Adv Powder Technol 30:961–973. https://doi.org/10.1016/j.apt.2019.02.010
Pedro SN, Freire MG, Freire CSR, Silvestre AJD (2019) Deep eutectic solvents comprising active
pharmaceutical ingredients in the development of drug delivery systems. Expert Opin Drug
Deliv 16:407–506. https://doi.org/10.1080/17425247.2019.1604680
Pena-Pereira F, Namieśnik J (2014) Ionic liquids and deep eutectic mixtures: sustainable solvents
for extraction processes. ChemSusChem 7:1784–1800. https://doi.org/10.1002/cssc.201301192
Pereira CV, Silva JM, Rodrigues L, Reis RL, Paiva A, Duarte ARC, Matias A (2019) Unveil the
anticancer potential of limomene based therapeutic deep eutectic solvents. Sci Rep 9:1–11.
https://doi.org/10.1038/s41598-019-51472-7
Phaechamud T, Tuntarawongsa S, Charoensuksai P (2015) Evaporation behavior and characterization of eutectic solvent and ibuprofen eutectic solution. AAPS Pharm Sci Tech 17:1213–1220.
https://doi.org/10.1208/s12249-015-0459-x
Prista LN, Alves AC, Morgado R, Lobo JS (2008) Tecnologia Farmacêutica – volume I. In:
Fundação Calouste Gulbenkian, 7th edn ISBN: 9789723109757
Reverchon E, Adami R, Cardea S, Porta GD (2009) Supercritical fluids processing of polymers
for pharmaceutical and medical applications. J Supercrit Fluids 47:484–492. https://doi.
org/10.1016/j.supflu.2008.10.001
Roda A, Matias AA, Paiva A, Duarte ARC (2019) Polymer science and engineering using deep
eutectic solvents. Polymers 11:1–22. https://doi.org/10.3390/polym11050912
Roda A, Santos F, Matias AA, Paiva A, Duarte ARC (2020) Design and processing of drug delivery formulations of therapeutic deep eutectic systems for tuberculosis. J Supercrit Fluids
161:104826. https://doi.org/10.1016/j.supflu.2020.104826
Ruß C, König B (2012) Low melting mixtures in organic synthesis - an alternative to ionic liquids?
Green Chem 14:2969–2982. https://doi.org/10.1039/c2gc36005e
Santana APR, Mora-Vargas JA, Guimarães TGS, Amaral CDB, Oliveira A, Gonzalez MH (2019)
Sustainable synthesis of natural deep eutectic solvents (NADES) by different methods. J Mol
Liq 293:1–6. https://doi.org/10.1016/j.molliq.2019.111452
Santos F, Leitão MIPS, Duarte ARC (2019) Properties of therapeutic deep eutectic solvents
of L-arginine and ethambutol for tuberculosis treatment. Molecules 24:1–12. https://doi.
org/10.3390/molecules24010055
Savjani KT, Gajjar AK, Savjani JK (2012) Drug solubility: importance and enhancement techniques. ISRN Pharm 2012:1–10. https://doi.org/10.5402/2012/195727
Serrano MC, Gutiérrez MC, Jiménez R, Ferrer ML, Del Monte F (2012) Synthesis of novel
lidocaine-releasing poly(diol-co-citrate) elastomers by using deep eutectic solvents. Chem
Commun 48:579–581. https://doi.org/10.1039/c1cc15284j
Shekaari H, Zafarani-Moattar MT, Shayanfar A, Mokhtarpour M (2018) Effect of choline chloride/ethylene glycol or glycerol as deep eutectic solvents on the solubility and thermodynamic properties of acetaminophen. J Mol Liq 249:1222–1235. https://doi.org/10.1016/j.
molliq.2017.11.057
Shen Q, Li X, Li W, Zhao X (2011) Enhanced intestinal absorption of daidzein by borneol/menthol eutectic mixture and microemulsion. AAPS Pharm Sci Tech 12:1044–1049. https://doi.
org/10.1208/s12249-011-9672-4
Silva JM, Reis RL, Paiva A, Duarte ARC (2018) Design of functional therapeutic deep eutectic solvents based on choline chloride and ascorbic acid. ACSS Sustain Chem Eng 6:10355–10363.
https://doi.org/10.1021/acssuschemeng.8b01687
Silva JM, Akkache S, Araújo AC, Masmoudi Y, Reis RL, Badens E, Duarte ARC (2019a)
Development of innovative medical devices by dispersing fatty acid eutectic blend on gauzes
using supercritical particle generation processes. Mater Sci Eng C 99:599–610. https://doi.
org/10.1016/j.msec.2019.02.012
F. Santos and A. R. C. Duarte
Patel RD, Raval MK, Bagathariya AA, Sheth NR (2019) Functionality improvement of nimesulide
by eutectic formation with nicotinamide: exploration using temperature-composition phase
diagram. Adv Powder Technol 30:961–973. https://doi.org/10.1016/j.apt.2019.02.010
Pedro SN, Freire MG, Freire CSR, Silvestre AJD (2019) Deep eutectic solvents comprising active
pharmaceutical ingredients in the development of drug delivery systems. Expert Opin Drug
Deliv 16:407–506. https://doi.org/10.1080/17425247.2019.1604680
Pena-Pereira F, Namieśnik J (2014) Ionic liquids and deep eutectic mixtures: sustainable solvents
for extraction processes. ChemSusChem 7:1784–1800. https://doi.org/10.1002/cssc.201301192
Pereira CV, Silva JM, Rodrigues L, Reis RL, Paiva A, Duarte ARC, Matias A (2019) Unveil the
anticancer potential of limomene based therapeutic deep eutectic solvents. Sci Rep 9:1–11.
https://doi.org/10.1038/s41598-019-51472-7
Phaechamud T, Tuntarawongsa S, Charoensuksai P (2015) Evaporation behavior and characterization of eutectic solvent and ibuprofen eutectic solution. AAPS Pharm Sci Tech 17:1213–1220.
https://doi.org/10.1208/s12249-015-0459-x
Prista LN, Alves AC, Morgado R, Lobo JS (2008) Tecnologia Farmacêutica – volume I. In:
Fundação Calouste Gulbenkian, 7th edn ISBN: 9789723109757
Reverchon E, Adami R, Cardea S, Porta GD (2009) Supercritical fluids processing of polymers
for pharmaceutical and medical applications. J Supercrit Fluids 47:484–492. https://doi.
org/10.1016/j.supflu.2008.10.001
Roda A, Matias AA, Paiva A, Duarte ARC (2019) Polymer science and engineering using deep
eutectic solvents. Polymers 11:1–22. https://doi.org/10.3390/polym11050912
Roda A, Santos F, Matias AA, Paiva A, Duarte ARC (2020) Design and processing of drug delivery formulations of therapeutic deep eutectic systems for tuberculosis. J Supercrit Fluids
161:104826. https://doi.org/10.1016/j.supflu.2020.104826
Ruß C, König B (2012) Low melting mixtures in organic synthesis - an alternative to ionic liquids?
Green Chem 14:2969–2982. https://doi.org/10.1039/c2gc36005e
Santana APR, Mora-Vargas JA, Guimarães TGS, Amaral CDB, Oliveira A, Gonzalez MH (2019)
Sustainable synthesis of natural deep eutectic solvents (NADES) by different methods. J Mol
Liq 293:1–6. https://doi.org/10.1016/j.molliq.2019.111452
Santos F, Leitão MIPS, Duarte ARC (2019) Properties of therapeutic deep eutectic solvents
of L-arginine and ethambutol for tuberculosis treatment. Molecules 24:1–12. https://doi.
org/10.3390/molecules24010055
Savjani KT, Gajjar AK, Savjani JK (2012) Drug solubility: importance and enhancement techniques. ISRN Pharm 2012:1–10. https://doi.org/10.5402/2012/195727
Serrano MC, Gutiérrez MC, Jiménez R, Ferrer ML, Del Monte F (2012) Synthesis of novel
lidocaine-releasing poly(diol-co-citrate) elastomers by using deep eutectic solvents. Chem
Commun 48:579–581. https://doi.org/10.1039/c1cc15284j
Shekaari H, Zafarani-Moattar MT, Shayanfar A, Mokhtarpour M (2018) Effect of choline chloride/ethylene glycol or glycerol as deep eutectic solvents on the solubility and thermodynamic properties of acetaminophen. J Mol Liq 249:1222–1235. https://doi.org/10.1016/j.
molliq.2017.11.057
Shen Q, Li X, Li W, Zhao X (2011) Enhanced intestinal absorption of daidzein by borneol/menthol eutectic mixture and microemulsion. AAPS Pharm Sci Tech 12:1044–1049. https://doi.
org/10.1208/s12249-011-9672-4
Silva JM, Reis RL, Paiva A, Duarte ARC (2018) Design of functional therapeutic deep eutectic solvents based on choline chloride and ascorbic acid. ACSS Sustain Chem Eng 6:10355–10363.
https://doi.org/10.1021/acssuschemeng.8b01687
Silva JM, Akkache S, Araújo AC, Masmoudi Y, Reis RL, Badens E, Duarte ARC (2019a)
Development of innovative medical devices by dispersing fatty acid eutectic blend on gauzes
using supercritical particle generation processes. Mater Sci Eng C 99:599–610. https://doi.
org/10.1016/j.msec.2019.02.012
F. Santos and A. R. C. Duarte