99
Mokhtarpour M, Shekaari H, Martinez F, Zafarani-Moattar MT (2019a) Study of naproxen in
some aqueous solutions of choline-based deep eutectic solvents: solubility measurements,
volumetric and compressibility properties. Int J Pharm 564:197–206. https://doi.org/10.1016/j.
ijpharm.2019.04.029
Mokhtarpour M, Shekaari H, Martinez F, Zafarani-Moattar MT (2019b) Effect of tetrabutylammonium bromide-based deep eutectic solvents on the aqueous solubility of indomethacin at various
temperatures: measurement, modeling, and prediction with three-dimensional Hansen solubility parameters. AAPS PharmSciTech 20:204. https://doi.org/10.1208/s12249-019-1373-4
Morrison HG, Sun CC, Neervannan S (2009) Characterization of thermal behavior of deep eutectic
solvents and their potential as drug solubilization vehicles. Int J Pharm 378:136–139. https://
doi.org/10.1016/j.ijpharm.2009.05.039
Moufawad T, Moura L, Ferreira M, Bricout H, Tilloy S, Monflier E, Costa Gomes M, Landy D,
Fourmentin S (2019) First evidence of cyclodextrin inclusion complexes in a deep eutectic solvent. ACS Sustain Chem Eng 7:6345–6351. https://doi.org/10.1021/acssuschemeng.9b00044
Moura L, Moufawad T, Ferreira M, Bricout H, Tilloy S, Monflier E, Costa Gomes MF, Landy D,
Fourmentin S (2017) Deep eutectic solvents as green absorbents of volatile organic pollutants.
Environ Chem Lett 15:747–753. https://doi.org/10.1007/s10311-017-0654-y
Nascimento PAM, Picheli FP, Lopes AM, Pereira JFB, Santos-Ebinuma VC (2019) Effects of
cholinium-based ionic liquids on Aspergillus Niger lipase: stabilizers or inhibitors. Biotechnol
Prog 35:e2838. https://doi.org/10.1002/btpr.2838
Niknaddaf F, Shahangian SS, Heydari A, Hosseinkhani S, Sajedi RH (2018) Deep eutectic solvents as a new generation of chemical chaperones. Chem Select 3:10603–10607. https://doi.
org/10.1002/slct.201802235
Nurunnabi M, Ibsen KN, Tanner EEL, Mitragotri S (2019) Oral ionic liquid for the treatment of
diet-induced obesity. Proc Natl Acad Sci U S A 116:25042–25047. https://doi.org/10.1073/
pnas.1914426116
Olivares B, Martínez F, Rivas L, Calderón C, M Munita J, R Campodonico P (2018) A natural
deep eutectic solvent formulated to stabilize β-lactam antibiotics. Sci Rep 8:14900. https://doi.
org/10.1038/s41598-018-33148-w
Palmelund H, Andersson MP, Asgreen CJ, Boyd BJ, Rantanen J, Löbmann K (2019) Tailor-made
solvents for pharmaceutical use? Experimental and computational approach for determining
solubility in deep eutectic solvents (DES). Int J Pharm X 1:100034. https://doi.org/10.1016/j.
ijpx.2019.100034
Pedro SN, Freire MG, Freire CSR, Silvestre AJD (2019) Deep eutectic solvents comprising active
pharmaceutical ingredients in the development of drug delivery systems. Expert Opin Drug
Deliv 16:497–506. https://doi.org/10.1080/17425247.2019.1604680
Pereira CV, Silva JM, Rodrigues L, Reis RL, Paiva A, Duarte ARC, Matias A (2019) Unveil the
anticancer potential of limomene based therapeutic deep eutectic solvents. Sci Re 9:14926.
https://doi.org/10.1038/s41598-019-51472-7
Potticary J, Hall C, Hamilton V, McCabe JF, Hall SR (2019) Deep eutomic solvents. https://arxiv.
org/abs/1902.08376v2
Pradeepkumar P, Rajendran NK, Alarfaj AA, Munusamy MA, Rajan M (2018) Deep eutectic
solvent-mediated FA-g-β-alanine-co-PCL drug carrier for sustainable and site-specific drug
delivery. ACS Appl Bio Mater (6):2094–2109. https://doi.org/10.1021/acsabm.8b00554
Pradeepkumar P, Sangeetha R, Gunaseelan S, Varalakshmi P, A Chuturgoon A, Rajan M (2019a)
Folic acid conjugated polyglutamic acid drug vehicle synthesis through deep eutectic solvent for targeted release of paclitaxel. Chem Select 4:10225–10235. https://doi.org/10.1002/
slct.201902256
Pradeepkumar P, Subbiah A, Rajan M (2019b) Synthesis of bio-degradable poly(2-hydroxyethyl
methacrylate) using natural deep eutectic solvents for sustainable cancer drug delivery. SN
Appl Sci 1:568. https://doi.org/10.1007/s42452-019-0591-4
Qi QM, Mitragotri S (2019) Mechanistic study of transdermal delivery of macromolecules
assisted by ionic liquids. J Control Release 311-312:162–169. https://doi.org/10.1016/j.
jconrel.2019.08.029
2 Deep Eutectic Solvents for Innovative Pharmaceutical Formulations
Mokhtarpour M, Shekaari H, Martinez F, Zafarani-Moattar MT (2019a) Study of naproxen in
some aqueous solutions of choline-based deep eutectic solvents: solubility measurements,
volumetric and compressibility properties. Int J Pharm 564:197–206. https://doi.org/10.1016/j.
ijpharm.2019.04.029
Mokhtarpour M, Shekaari H, Martinez F, Zafarani-Moattar MT (2019b) Effect of tetrabutylammonium bromide-based deep eutectic solvents on the aqueous solubility of indomethacin at various
temperatures: measurement, modeling, and prediction with three-dimensional Hansen solubility parameters. AAPS PharmSciTech 20:204. https://doi.org/10.1208/s12249-019-1373-4
Morrison HG, Sun CC, Neervannan S (2009) Characterization of thermal behavior of deep eutectic
solvents and their potential as drug solubilization vehicles. Int J Pharm 378:136–139. https://
doi.org/10.1016/j.ijpharm.2009.05.039
Moufawad T, Moura L, Ferreira M, Bricout H, Tilloy S, Monflier E, Costa Gomes M, Landy D,
Fourmentin S (2019) First evidence of cyclodextrin inclusion complexes in a deep eutectic solvent. ACS Sustain Chem Eng 7:6345–6351. https://doi.org/10.1021/acssuschemeng.9b00044
Moura L, Moufawad T, Ferreira M, Bricout H, Tilloy S, Monflier E, Costa Gomes MF, Landy D,
Fourmentin S (2017) Deep eutectic solvents as green absorbents of volatile organic pollutants.
Environ Chem Lett 15:747–753. https://doi.org/10.1007/s10311-017-0654-y
Nascimento PAM, Picheli FP, Lopes AM, Pereira JFB, Santos-Ebinuma VC (2019) Effects of
cholinium-based ionic liquids on Aspergillus Niger lipase: stabilizers or inhibitors. Biotechnol
Prog 35:e2838. https://doi.org/10.1002/btpr.2838
Niknaddaf F, Shahangian SS, Heydari A, Hosseinkhani S, Sajedi RH (2018) Deep eutectic solvents as a new generation of chemical chaperones. Chem Select 3:10603–10607. https://doi.
org/10.1002/slct.201802235
Nurunnabi M, Ibsen KN, Tanner EEL, Mitragotri S (2019) Oral ionic liquid for the treatment of
diet-induced obesity. Proc Natl Acad Sci U S A 116:25042–25047. https://doi.org/10.1073/
pnas.1914426116
Olivares B, Martínez F, Rivas L, Calderón C, M Munita J, R Campodonico P (2018) A natural
deep eutectic solvent formulated to stabilize β-lactam antibiotics. Sci Rep 8:14900. https://doi.
org/10.1038/s41598-018-33148-w
Palmelund H, Andersson MP, Asgreen CJ, Boyd BJ, Rantanen J, Löbmann K (2019) Tailor-made
solvents for pharmaceutical use? Experimental and computational approach for determining
solubility in deep eutectic solvents (DES). Int J Pharm X 1:100034. https://doi.org/10.1016/j.
ijpx.2019.100034
Pedro SN, Freire MG, Freire CSR, Silvestre AJD (2019) Deep eutectic solvents comprising active
pharmaceutical ingredients in the development of drug delivery systems. Expert Opin Drug
Deliv 16:497–506. https://doi.org/10.1080/17425247.2019.1604680
Pereira CV, Silva JM, Rodrigues L, Reis RL, Paiva A, Duarte ARC, Matias A (2019) Unveil the
anticancer potential of limomene based therapeutic deep eutectic solvents. Sci Re 9:14926.
https://doi.org/10.1038/s41598-019-51472-7
Potticary J, Hall C, Hamilton V, McCabe JF, Hall SR (2019) Deep eutomic solvents. https://arxiv.
org/abs/1902.08376v2
Pradeepkumar P, Rajendran NK, Alarfaj AA, Munusamy MA, Rajan M (2018) Deep eutectic
solvent-mediated FA-g-β-alanine-co-PCL drug carrier for sustainable and site-specific drug
delivery. ACS Appl Bio Mater (6):2094–2109. https://doi.org/10.1021/acsabm.8b00554
Pradeepkumar P, Sangeetha R, Gunaseelan S, Varalakshmi P, A Chuturgoon A, Rajan M (2019a)
Folic acid conjugated polyglutamic acid drug vehicle synthesis through deep eutectic solvent for targeted release of paclitaxel. Chem Select 4:10225–10235. https://doi.org/10.1002/
slct.201902256
Pradeepkumar P, Subbiah A, Rajan M (2019b) Synthesis of bio-degradable poly(2-hydroxyethyl
methacrylate) using natural deep eutectic solvents for sustainable cancer drug delivery. SN
Appl Sci 1:568. https://doi.org/10.1007/s42452-019-0591-4
Qi QM, Mitragotri S (2019) Mechanistic study of transdermal delivery of macromolecules
assisted by ionic liquids. J Control Release 311-312:162–169. https://doi.org/10.1016/j.
jconrel.2019.08.029
2 Deep Eutectic Solvents for Innovative Pharmaceutical Formulations